{"title":"13972-Rat","description":"","products":[{"product_id":"cd4-rat-mab-15-8a2","title":"CD4, Rat, mAb 15-8A2","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody recognizes rat CD4 antigen (MW 52 kDa) and is reactive with all common inbred strains. 15-8A2 is derived from hybridization of mouse SP2\/0 myeloma cells with spleen cells from Balb\/c mice immunized with WAG\/Rij spleen cells.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161985827,"sku":"HYBHM3001100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_267669c0-ec45-43aa-94f7-3487b91fb82c.png?v=1753032186"},{"product_id":"cd4-rat-mab-15-8a2-20-ug","title":"CD4, Rat, mAb 15-8A2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162018595,"sku":"HYBHM300120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1adf32a6-40e7-4058-a550-7a1bfb7e1229.png?v=1753032189"},{"product_id":"cd8-rat-mab-15-11c5","title":"CD8, Rat, mAb 15-11C5","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody recognizes rat CD8 antigen (MW 34 kDa and 39 kDa) and is reactive with all common inbred strains. 15-11C5 is derived from hybridization of mouse SP2\/0 myeloma cells with spleen cells from Balb\/c mice immunized with WAG\/Rij spleen cells.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Paraffin Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162051363,"sku":"HYBHM3003100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f63400ae-de15-478b-a4c3-3a37fdc27ede.png?v=1753032193"},{"product_id":"cd8-rat-mab-15-11c5-20-ug","title":"CD8, Rat, mAb 15-11C5, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162084131,"sku":"HYBHM300320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_232d62fc-4dcd-4ec8-93ca-23b2db5a8147.png?v=1753032196"},{"product_id":"endothelial-cell-antigen-rat-mab-reca-1","title":"Endothelial cell antigen, Rat, mAb RECA-1","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody RECA-1 reacts with Rat Endothelial Cell Antigen (RECA), a cell surface antigen (MCA970R) on rat endothelial cells. Endothelial cells (EC) line the interior of all blood vessels and are the key players in the angiogenesis cascade. EC are the first cells and barrier that vehicles or medicines encounter after systemic delivery. Furthermore, they have a signaling function to the cells of the immune system to indicate the status of the surrounding tissue. RECA-1is at least reactive with the rat MHC-haplotype; Lewis (TR-11), BN (RT-1n) and OA (RT-1u). RECA-1 antibody has been successfully applied in staining of viable endothelial cells in vitro, and of vascular endothelium in vivo. No reactivity of the RECA-1 monoclonal antibody was seen with other cell types e.g. fibroblasts, leukocytes and non endothelial stromal cells nor with other various tested species other than rat e.g. mouse, rabbit, sheep, goat and human. RECA-1 is a promising antibody for rat endothelial cell studies, and in particular for further defining nature and function of endothelial cell-specific antigens\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunofluorescence , Paraffin Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162116899,"sku":"HYBHM3012100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d5c6f13f-22de-4f94-901c-715561a28d92.png?v=1753032199"},{"product_id":"endothelial-cell-antigen-rat-mab-reca-1-20-ug","title":"Endothelial cell antigen, Rat, mAb RECA-1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162149667,"sku":"HYBHM301220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_aa3f290a-8231-4b20-a443-8b141e9f39ce.png?v=1753032202"},{"product_id":"l-afadin-rat-mab-3","title":"L-Afadin, Rat, mAb 3","description":"\u003cul\u003e\n\u003cli\u003eAfadin is an actin filament-binding protein that is involved in cell-cell adherens junctions (AJs) which directly interacts with the alpha herpus virus receptor, a member of the immunoglobulin supergene family. Afadin is colocalized with nectin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. L-Afadin has been isolated as an F-actin-binding protein from rat brain. L-afadin is ubiquitously expressed and specifically localized at zonula adherens (ZA) in epithelial cells and at cell-cell adherens junctions (AJs) in non-epithelial cells. L-afadin has a splice variant, named small intestine absorptive afadin (s-afadin) which is abundantly expressed in neural tissue. Monoclonal antibody 3 has been raised against peptide 1814-1829 aa of rat l-afadin. Monoclonal antibody 3 cross reacts with human, mouse and dog l-afadin.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162182435,"sku":"HYBHM3013100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5dbd8d63-8bb0-4932-8e5c-ec04be1aaf2d.png?v=1753032206"},{"product_id":"l-afadin-rat-mab-3-20-ug","title":"L-Afadin, Rat, mAb 3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162215203,"sku":"HYBHM301320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_19ac39cd-e663-42e1-bef3-3b13237c15bd.png?v=1753032209"},{"product_id":"caveolin-1-rat-mab-7c8","title":"Caveolin-1, Rat, mAb 7C8","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 7C8 recognizes rat caveolin-1, a membrane protein of ~22 kDa. Caveolaeare sphingomyelin\/cholesterol-rich membrane domains first discovered as membrane invaginations onthe surface of endothelial and epithelial cells. Caveolae are present in most cells, but are especiallyabundant in adipocytes. In addition to caveolins only two major protein components of caveolae wereidentified, namely the semicarbazide sensitive amine oxidase (SSAO) and the scavenger receptorCD36. Caveolin cycles between the plasma membrane and intracellular compartments via theendocytotic pathway. Caveolin is involved in the rapid intracellular transport of newly synthesizedcholesterol from the ER directly to the caveolae. Caveolin plays an important role in multiple signalingpathways, molecular transport and cellular proliferation and differentiation. Caveolin binds toendothelial nitric oxide synthase leading to enzyme inhibition. Furthermore caveolin is a candidatetumor suppressor gene in many tumors. The specific functions of caveolin-1\/caveolae are highly celland context dependent.The monoclonal antibody 7C8 recognizes caveolin-1α as well as caveolin-1β, which are present inmany tissues, like aorta, heart, muscle, lung, adipose white, brown and epidydimal fat.The monoclonal antibody 7C8 can be used to immuno-isolate caveolae.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunofluorescence , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162247971,"sku":"HYBHM3014100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_752cac8f-6f19-4c5f-8d04-5533d8032bc5.png?v=1753032213"},{"product_id":"caveolin-1-rat-mab-7c8-20-ug","title":"Caveolin-1, Rat, mAb 7C8, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162280739,"sku":"HYBHM301420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b5f00e4c-44a8-4fc7-89a9-cf10bfc16182.png?v=1753032216"},{"product_id":"c5ar-rat-mab-r63","title":"C5aR, Rat, mAb R63","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody R63 reacts with the rat receptor for C5a (CD88). The rat anaphylatoxin C5a, a 77-amino acid glycopolypeptide generated by proteolytic cleavage of C5, is one of the most potent inflammatory chemo attractants and interacts with two C5a receptors, C5aR and C5L2.- Most of the C5a effects are mediated through C5aR. C5aR is known to be crucial in the initiation of acute inflammatory responses. C5a receptor is a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by leukocytes such as neutrophils, eosinophils, basophils, monocytes, dendritic cells and mast cells. C5aR can be expressed on both immune and non-immune cells. The latter, include vascular endothelial cells, cardiomyocytes and bronchial epithelial cells. Signaling of C5aR involves intracellular calcium mobilization and activation of among others protein kinase- B (PKB) and protein phospholipase D (PLD) pathways. High C5aR expression levels have been associated with the pathogenesis of many inflammatory conditions, autoimmune and neurodegenerative diseases like rheumatoid arthritis, multiple sclerosis, atherosclerosis and inflammatory bowel disease. In vivo blockade of C5aR greatly reduces inflammatory injury. Using immunohistology there is no evidence for non-myeloid expression in healthy control rats. However, under inflammatory situations, the C5aR was found to be upregulated in various organs and tissues including the liver.Antibody\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162313507,"sku":"HYBHM3017100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3da24eab-3bcb-46f6-ad3a-a95c37b72667.png?v=1753032219"},{"product_id":"c5ar-rat-mab-r63-20-ug","title":"C5aR, Rat, mAb R63, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162346275,"sku":"HYBHM301720UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d9d7a88e-64c5-4782-9a89-e056b8e1e58c.png?v=1753032222"},{"product_id":"asgpr-rat-mab-8d7","title":"ASGPR, Rat, mAb 8D7","description":"\u003cul\u003e\n\u003cli\u003eThe asialoglycoprotein (ASGP) receptor is a transmembrane hepatocellular surface carbohydrate binding glycoproteins lacking terminal sialic acid residues (asialoglycoproteins). Characterization of the ASGP receptor- revealed its functional role in the binding, internalization and transport of a wide range of glycoproteins, which have exposed galactose or N-acetylgalactosamine residues, via the process of receptor-mediated endocytosis (RME). The ASGP receptor can bind a variety of important plasma proteins including transport proteins (i.e. transferrin), enzymes such as alkaline phosphatase, immunoglobulins including IgA, apoptotic hepatocytes, fibronectin and platelets. Additionally, the expression of the ASGP receptor has been clinically correlated to the level of hepatic function that is lost during liver diseases related to cancer, viral hepatitis, and cirrhosis. The ASGP receptor consists of major and minor subunits, which in the rat were identified as rat hepatic lectin (RHL) 1 and RHL 2\/3, with molecular weights of respectively 42, 49 and 54 kDa. The selective binding (calcium and pH depended) and uptake of terminal galactosyl bearing proteins requires the formation of hetero-oligomers between these major and minor forms The total ASGP receptor population consisted of two functionally distinct receptor populations, designated State 1 and State 2, which were involved in the endocytosis and intracellular processing of ligands by different pathways. The monoclonal antibody 8D7 recognizes a subunit-specific epitope on RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunoassays , Immunofluorescence , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162379043,"sku":"HYBHM3020100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3b4dc464-ac02-4241-a445-7a232e7b4349.png?v=1753032226"},{"product_id":"asgpr-rat-mab-8d7-20-ug","title":"ASGPR, Rat, mAb 8D7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162411811,"sku":"HYBHM302020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_66ca5e8f-a27a-46db-a13d-da63abb40614.png?v=1753032229"},{"product_id":"asgpr-rat-mab-8d7-fitc","title":"ASGPR, Rat, mAb 8D7, FITC","description":"\u003cul\u003e\n\u003cli\u003eThe asialoglycoprotein (ASGP) receptor is a transmembrane hepatocellular surface carbohydrate binding glycoproteins lacking terminal sialic acid residues (asialoglycoproteins). Characterization of the ASGP receptor- revealed its functional role in the binding, internalization and transport of a wide range of glycoproteins, which have exposed galactose or N-acetylgalactosamine residues, via the process of receptor-mediated endocytosis (RME). The ASGP receptor can bind a variety of important plasma proteins including transport proteins (i.e. transferrin), enzymes such as alkaline phosphatase, immunoglobulins including IgA, apoptotic hepatocytes, fibronectin and platelets. Additionally, the expression of the ASGP receptor has been clinically correlated to the level of hepatic function that is lost during liver diseases related to cancer, viral hepatitis, and cirrhosis. The ASGP receptor consists of major and minor subunits, which in the rat were identified as rat hepatic lectin (RHL) 1 and RHL 2\/3, with molecular weights of respectively 42, 49 and 54 kDa. The selective binding (calcium and pH depended) and uptake of terminal galactosyl bearing proteins requires the formation of hetero-oligomers between these major and minor forms The total ASGP receptor population consisted of two functionally distinct receptor populations, designated State 1 and State 2, which were involved in the endocytosis and intracellular processing of ligands by different pathways. The monoclonal antibody 8D7 recognizes a subunit-specific epitope on RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunoassays , Immunofluorescence , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162444579,"sku":"HYBHM3020F100UG","price":1012.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f82ca971-b151-4711-8eb3-dde16587a202.png?v=1753032233"},{"product_id":"asgpr-rat-mab-8d7-fitc-20-ug","title":"ASGPR, Rat, mAb 8D7, FITC, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162477347,"sku":"HYBHM3020F20UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_79a3772a-e15c-40ea-920f-d4eedc8b476f.png?v=1753032236"},{"product_id":"cd26-rat-mab-5e8","title":"CD26, Rat, mAb 5E8","description":"\u003cul\u003e\n\u003cli\u003eDipeptidyl peptidase IV (DPP IV) is widely distributed in a number of mammalian tissues and is suggested to play an important role in various kinds of biological processes. DPP IV (CD26) is a serine-type protease that removes the amino-terminal dipeptide from peptide substrate provided that the penultimate amino acid residue is proline or alanine. DPP IV plays an important role in the reclamation of peptide nitrogen from larger peptides. The monoclonal antibody 5E8 reacts with DPP IV present on the apical surface of epithelial cells in the pancreas, small intestine, colon, and bile duct. Furthermore antibody 5E8 reacts with DPP IV on the laminar portions of the proximal renal tubule cells, and, weakly, on the glomeruli.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162510115,"sku":"HYBHM3021100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a1b2e934-dfa1-4a5f-a85c-21980095e6ef.png?v=1753032240"},{"product_id":"cd26-rat-mab-5e8-20-ug","title":"CD26, Rat, mAb 5E8, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162542883,"sku":"HYBHM302120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6090e986-5000-4904-aec9-542209ba27ba.png?v=1753032243"},{"product_id":"sp-d-rat-mab-iiih3","title":"SP-D, Rat, mAb IIIH3","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody IIIH3 recognizes the rat surfactant protein D (SP-D). SP-D belongs to the collectin familiy. These proteins are oligomeric proteins composed of carbohydrate-recognition domains (CRD) attached to collagenous regions. They are structurally similar to the ficolins although they make use of different CRD structures: C-type lectin domain for the collectins. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages. Monoclonal antibody IIIH3 specific for rat surfactant protein D shows significant cross reactivity with human SP-D.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162575651,"sku":"HYBHM3022100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5dfa653b-bf1d-4950-99d3-67bba623bdd5.png?v=1753032246"},{"product_id":"sp-d-rat-mab-iiih3-20-ug","title":"SP-D, Rat, mAb IIIH3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162608419,"sku":"HYBHM302220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8bff106e-1857-4f3b-a536-88c8bd7dc040.png?v=1753032250"},{"product_id":"sp-d-rat-mab-vif9","title":"SP-D, Rat, mAb VIF9","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody VIF9 recognizes the rat surfactant protein D (SP-D). SP-D belongs to the collectin familiy. These proteins are oligomeric proteins composed of carbohydrate-recognition domains (CRD) attached to collagenous regions. They are structurally similar to the ficolins although they make use of different CRD structures: C-type lectin domain for the collectins. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages. Monoclonal antibody VIF9 specific for rat surfactant protein D shows significant cross reactivity with human SP-D. Monoclonal antibody VIF9 stains paraffin sections of rat lung. It cannot be used for staining of paraffin sections of human lung. It can also be used as detection antibody for Elisa on wells coated with human SP-D.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162641187,"sku":"HYBHM3023100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_670c9574-12ec-480d-ab14-bcecd7a62ac9.png?v=1753032254"},{"product_id":"sp-d-rat-mab-vif9-20-ug","title":"SP-D, Rat, mAb VIF9, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162673955,"sku":"HYBHM302320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f37e371b-37ff-4140-bb86-7239af2e3fc1.png?v=1753032258"},{"product_id":"sp-d-rat-mab-vif9-500-ug","title":"SP-D, Rat, mAb VIF9, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162706723,"sku":"HYBHM3023500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2c1b080c-bcc5-4739-bd55-76ae47934336.png?v=1753032261"},{"product_id":"sp-d-rat-mab-ivg8","title":"SP-D, Rat, mAb IVG8","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody IVG8 recognizes the rat surfactant protein D (SP-D). SP-D belongs to the collectin familiy. These proteins are oligomeric proteins composed of carbohydrate-recognition domains (CRD) attached to collagenous regions. They are structurally similar to the ficolins although they make use of different CRD structures: C-type lectin domain for the collectins. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages. Monoclonal antibody IVG8 specific for rat surfactant protein D shows significant cross reactivity with human SP-D. Monoclonal antibody IVG8 stains paraffin sections of rat lung. It cannot be used for staining of paraffin sections of human lung. It can also be used as detection antibody for Elisa on wells coated with human SP-D.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162739491,"sku":"HYBHM3024100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6672f197-d8c1-4c4e-a4e4-42586919e3da.png?v=1753032264"},{"product_id":"sp-d-rat-mab-ivg8-20-ug","title":"SP-D, Rat, mAb IVG8, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162772259,"sku":"HYBHM302420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_cc9b1c2f-8754-4c24-b05a-79ee8afabb9f.png?v=1753032268"},{"product_id":"cd163-rat-mab-ed2","title":"CD163, Rat, mAb ED2","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody ED2 reacts with rat CD163 cell surface glycoprotein, a 175 kDa molecule also known as ED2. CD163 is expressed by approximately 50% of peritoneal macrophages, a subset of splenic macrophages, and by macrophages in most other tissues. However, it is not expressed by monocytes, alveolar macrophages or microglial cells. Macrophage scavenger receptor CD163 also known as hemoglobin scavenger receptor (HbSR) is a member of the scavenger receptor cysteine-rich family (SRCR). Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found to be involved in the development of atherosclerosis. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens indicating a potential role in host defence. CD163 is involved in the endocytosis of hemoglobin:haptoglobin complexes and is able to counter oxidative tissue damage induced by hemoglobin after hemolysis. Recent results identify new anti-inflammatory and cytoprotective effector pathways in monocytes\/macrophages related to hemoglobin scavenging and metabolism, which may be relevant for atheroprotection and wound healing.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunoprecipitation , Paraffin Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162805027,"sku":"HYBHM3025100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_844bcb8d-71b0-4ede-86dc-ed12001c884d.png?v=1753032271"},{"product_id":"cd163-rat-mab-ed2-20-ug","title":"CD163, Rat, mAb ED2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162837795,"sku":"HYBHM302520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_09a0cfd8-7bd4-4584-854a-942349c6533d.png?v=1753032274"},{"product_id":"sr-bi-rat-mab-3d12","title":"SR-BI, Rat, mAb 3D12","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody 3D12 reacts with rat class B scavenger receptor type I (SR-BI). Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found in the development of atherosclerosis and other macrophage-associated functions. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens. This finding indicates a potential role in host defense. SR-BI belongs together with CD36 to the class B scavenger receptor family. SR-BI is a multiligand membrane protein existing in various organs such as the liver and various cell types such as endothelial cells, macrophages, brain cells, Leydig cells and Sertoli cells. SR-BI has been found as a receptor for phospholipids, free and (lipo)protein-bound ApoE, lipid-bound ApoA-I, HDL, hypochlorite-modified LDL and more. In liver, the PDZK-1 (and possible other PDZ domains) of SR-BI has been found to be essential for cell surface expression and, hence, reverse cholesterol transport. In the brain, the presence of SR-BI seems to be involved in the uptake of oxidatively modified lipoproteins and beta-amyloid protein complexed with ApoE, suggesting SR-BI to be an important tool for studies on neurodegenerative disorders. In the testis, SR-BI is expressed in two somatic cell types: Leydig cells and Sertoli cells. SR-BI functions at least partly as a phosphatidyl serine receptor (PSR), enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation. Monoclonal antibody 3D12 blocks the biological activity of rat SR-BI. For example, it inhibits the ability of SR-BI to mediate the corporation of lipids of HDL by SR-BI expressing cells.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162870563,"sku":"HYBHM3027100UG","price":1086.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5973cc65-c32f-4d64-a588-60bede03f581.png?v=1753032278"},{"product_id":"sr-bi-rat-mab-3d12-20-ug","title":"SR-BI, Rat, mAb 3D12, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162903331,"sku":"HYBHM302720UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_beee5b26-d58a-49b8-b4b0-fef55d929310.png?v=1753032282"},{"product_id":"c3ar-rat-mab-74","title":"C3aR, Rat, mAb 74","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 74 reacts with the rat receptor for C3a. The monoclonal antibody 74 is in the literature also referred to as clone rC3aRZ1. In the course of complement activation the C3a receptor functions as the cell surface receptor for the anaphylatoxin C3a, the C-terminal 77 amino acid cleavage product of the alpha chain of C3, but not for C3a-desArg. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3a receptor, a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 54 kDa C3a receptor is widely distributed in myeloid cells, peripheral tissues and the central nervous system. Expression of C3aR has been demonstrated on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells and is increased in inflammatory conditions. No C3aR expression was detectable on lymphocytes and on tonsillar B cells even after stimulation.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162936099,"sku":"HYBHM3028100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0dccca99-dc75-4ef9-92a2-584750014fac.png?v=1753032285"},{"product_id":"c3ar-rat-mab-74-20-ug","title":"C3aR, Rat, mAb 74, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614162968867,"sku":"HYBHM302820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_cdd57de7-df08-4997-822b-3ca063c89dd6.png?v=1753032289"},{"product_id":"mpo-rat-mab-2d4","title":"MPO, Rat, mAb 2D4","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 2D4 reacts with rat myeloperoxidase (MPO). MPO is a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has more attracted clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections. The monoclonal antibody 2D4 cross reacts with mouse MPO.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunoassays , Immunofluorescence\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163001635,"sku":"HYBHM3030100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_07378c30-ddc6-44d0-9fec-de3781b0840f.png?v=1753032292"},{"product_id":"mpo-rat-mab-2d4-20-ug","title":"MPO, Rat, mAb 2D4, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163034403,"sku":"HYBHM303020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_024e000e-76e3-45ec-9039-53c5748fb5ee.png?v=1753032295"},{"product_id":"mpo-rat-mab-2d4-500-ug","title":"MPO, Rat, mAb 2D4, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163067171,"sku":"HYBHM3030500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6afeafe1-2072-417d-9a7b-32940178d6a3.png?v=1753032298"},{"product_id":"mpo-rat-mab-2d4-biotin-50-ug","title":"MPO, Rat, mAb 2D4, Biotin, 50 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163099939,"sku":"HYBHM3030BT50UG","price":666.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_131fbd73-a3ef-4d33-9feb-c5aee8e42c7a.png?v=1753032302"},{"product_id":"mpo-rat-mab-2d4-fitc","title":"MPO, Rat, mAb 2D4, FITC","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 2D4 reacts with rat myeloperoxidase (MPO). MPO is a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has more attracted clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections. The monoclonal antibody 2D4 cross reacts with mouse MPO.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunoassays , Immunofluorescence\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163132707,"sku":"HYBHM3030F100UG","price":1204.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_90ab903a-08c2-4578-9458-7b45e65b11e2.png?v=1753032305"},{"product_id":"mpo-rat-mab-2d4-fitc-20-ug","title":"MPO, Rat, mAb 2D4, FITC, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163165475,"sku":"HYBHM3030F20UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0314a2f8-11e5-484c-86cf-742205e8d536.png?v=1753032308"},{"product_id":"c3-c3b-rat-mab-2b10b9b2-100-ug","title":"C3\/C3b, Rat, mAb 2B10B9B2, \u003e100 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163198243,"sku":"HYBHM3031100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_853fcee7-0f61-432d-8790-4a2ab4c88114.png?v=1753032312"},{"product_id":"crry-rat-mab-tld-1c11","title":"Crry, Rat, mAb TLD-1C11","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody TLD-1C11 reacts with rat-complement regulator Crry. Complement comprises a system of soluble serum proteins that, upon activiation by antibody (classical pathway), sugars (lectin pathway), or bacterial and foreign surfaces (alternative pathway), directly causes cell damage. Complement is constantly activated at low levels in serum, requiring cells to be protect themselves from damage. In human, cells are protected from complement-mediated damage by expression of membrane-bound complement regulatory proteins, which act at serveral points along the cascade. Human cells are protected by decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and membrane attack complex inhibitor protein 1 (MIN1, CD59). Furthermore the rat analogues of DAF, MCP and CD59 have been characterized. Rats and mice express a unique membrane complement regulator of the activating pathways, called complement receptor type-1 related gene Y (Crry). In rats there are two isoforms of Crry, with six or seven short consensus repeats (SCR), encoding 65-70 and 75-85 kDa proteins, respectively, which are both transmembrane anchored. Although Crry has the functional properties of both DAF and MCP, it does not replace them. All rat blood cells express Crry whereas approximately 37 and 39% of the rat T cells express respectively DAF and CD59. Studies in rat revealed that despite lacking DAF and CD59, these double-negative rat T cells were not more susceptible to homologous complement lysis than cells that expressed both DAF and CD59. However, blocking of the only other known rat complement regulator, Crry, enhanced lysis only at the double-negative cells. In rats, Crry exerts powerful control in the activation pathways where it acts both as a cofactor and as a decay accelerator to inactivate convertases. Crry has been succesfully expressed and refolded in bacteria. The refolded protein has full-complement regulatory activity in vitro, and has been applied in rat models of arthritis and other inflammatory diseases. The monoclonal antibody TLD-1C11 can be used to block autoimmune phenomena in rats.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunofluorescence , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163231011,"sku":"HYBHM3032100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9c1f91f9-58cc-46a9-bdf1-7103c5149960.png?v=1753032286"},{"product_id":"crry-rat-mab-tld-1c11-20-ug","title":"Crry, Rat, mAb TLD-1C11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614163263779,"sku":"HYBHM303220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e46dac2e-e436-4cfd-b7d6-861b1d9d582b.png?v=1753032289"},{"product_id":"c5b-9-rat-mab-2a1","title":"C5b-9, Rat, mAb 2A1","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 2A1 recognizes rat C5b-9. The antibody was shown to compete with antibodies to human C9 for its binding site on the C5b-9 complex, indicating that the reactive epitope is located on the C9 molecule. C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive.C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164050211,"sku":"HYBHM3033100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_35f8aa0b-0a1a-4a5c-a919-5ad2d4e6ab0d.png?v=1753032296"},{"product_id":"c5b-9-rat-mab-2a1-20-ug","title":"C5b-9, Rat, mAb 2A1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164214051,"sku":"HYBHM303320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d844e55e-90be-4ae2-a90d-c5a0d636cdae.png?v=1753032299"},{"product_id":"c5b-9-rat-mab-2a1-500-ug","title":"C5b-9, Rat, mAb 2A1, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164246819,"sku":"HYBHM3033500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d8680c20-8400-4489-8fd5-64e5e3a2176a.png?v=1753032302"},{"product_id":"c6-rat-mab-3g11","title":"C6, Rat, mAb 3G11","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 3G11 reacts specifically with rat C6. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 membrane attack complex. Complement component C6 is part of this C5b-9 complex. This complex is assembled from five precursor molecules in the serum. The final step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. The rat remnant kidney model had been widely used to identify mechanisms responsible for the progression of renal disease. Proteinuria is nephrotoxic and contributes to the progression of renal injury. Activation of complement in proteinuric urine results in tubular and interstitial damage. In C6-deficient rats, acute interstitial changes resolved despite ongoing proteinuria. This suggests that C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. The monoclonal antibody 3G11 was raised by immunization of mice with C6 isolated from rat serum. Monoclonal antibody 3G11 can be used as detector in immuno assays detect C5b-9 in both serum and urine.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164279587,"sku":"HYBHM3034100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a780497c-6bec-420d-9c44-894759d0604e.png?v=1753032305"},{"product_id":"c6-rat-mab-3g11-20-ug","title":"C6, Rat, mAb 3G11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164312355,"sku":"HYBHM303420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9f80419f-1594-4f92-88e3-786c69b6bb3a.png?v=1753032309"},{"product_id":"cd55-rat-mab-rdiii-7","title":"CD55, Rat, mAb RDIII-7","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody RDIII-7 recognizes complement decay accelerating factor (DAF), also designated as CD55. RDIII-7 recognizes the common extracellular SCR region of CD55, detecting all isoforms of the protein. Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP).\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164345123,"sku":"HYBHM3035100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_19d0cf55-b77f-4566-9690-fded2671798c.png?v=1753032312"},{"product_id":"cd55-rat-mab-rdiii-7-20-ug","title":"CD55, Rat, mAb RDIII-7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164377891,"sku":"HYBHM303520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_855116ee-de8e-4d61-a753-3f16c76b390b.png?v=1753032315"},{"product_id":"cd55-rat-mab-rdii-24","title":"CD55, Rat, mAb RDII-24","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody RDII-24 recognizes complement decay accelerating factor (DAF), also designated as CD55.. Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP).\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164410659,"sku":"HYBHM3036100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ca6b2705-a67c-4b10-90e5-e6531f5c1ca2.png?v=1753032319"},{"product_id":"cd55-rat-mab-rdii-24-20-ug","title":"CD55, Rat, mAb RDII-24, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164443427,"sku":"HYBHM303620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6c9bcf59-d597-41c9-8bf1-f172afbd2a04.png?v=1753032322"},{"product_id":"cd59-glycoprotein-rat-mab-th9","title":"CD59 glycoprotein, Rat, mAb TH9","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody TH9 recognizes rat CD59. Rat CD59 was previously known as rat inhibitory protein (RIP) and it is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 regulates the formation and function of the lytic C5b-9 complex by binding C8 and preventing the unfolding and membrane insertion of C9 and by binding C9 and restricting its polymerization.CD59 is a small (18 - 25 kDa) molecule, linked to the cell membrane through a glycosyl phosphatidylinositol (GPI) anchor and comprising 77 amino acids with a single N-linked carbohydrate group at Asn-18. Analogues of CD59 can be found in all species with similar structures and sizes.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614164476195,"sku":"HYBHM3037100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_55691637-cdd2-4b0b-8c98-095b16363ed6.png?v=1753032325"}],"url":"https:\/\/chromspec.com\/collections\/13972-rat.oembed?page=6","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}