{"title":"14829-C1q","description":"","products":[{"product_id":"c1q-mouse-elisa-kit-1-x-96-det","title":"C1q, Mouse, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eC1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. The formation of an antibodyantigen complex (immune complex) is the principal way of activating the classical pathway of the complement system. C1q triggers the activation process when it docks onto antibodies within these immune complexes. In this way, C1q acts to bridge the innate and adaptive immune systems. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto-antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defense and clearance of immune complexes.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614111850787,"sku":"HYBHK21101","price":1379.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_acd7e8e1-f2d2-4441-8e12-72343e1bd1f7.png?v=1753030324"},{"product_id":"c1q-mouse-elisa-kit-2-x-96-det","title":"C1q, Mouse, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\u003cli\u003eC1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. The formation of an antibodyantigen complex (immune complex) is the principal way of activating the classical pathway of the complement system. C1q triggers the activation process when it docks onto antibodies within these immune complexes. In this way, C1q acts to bridge the innate and adaptive immune systems. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto-antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defense and clearance of immune complexes.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614111883555,"sku":"HYBHK21102","price":2271.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ed0adab0-55aa-45b2-a2f1-0b491d73e7e9.png?v=1753030327"}],"url":"https:\/\/chromspec.com\/collections\/14829-c1q.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}