{"title":"14864-Human Elisa Kits C","description":"","products":[{"product_id":"c3d-human-elisa-kit-1-x-96-det","title":"C3d, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eThe Human C3d ELISA is designed to detect human C3d. What sets this assay apart is its utilization of a distinctive antibody that selectively targets the C3d region of the alpha chain. This way it specifically distinguishes between native and activated C3 proteins. \u003c\/li\u003e\n\u003cli\u003eThis ELISA can aid in advancing treatment options for various diseases such as transplantation rejection, kidney diseases, age-related macular degeneration (AMD) and inflammatory diseases\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614112506147,"sku":"HYBHK301701","price":1493.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e0a6e841-a0d5-409b-b99c-a9b4d5464a31.png?v=1753030238"},{"product_id":"c3d-human-elisa-kit-2-x-96-det","title":"C3d, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eThe Human C3d ELISA is designed to detect human C3d. What sets this assay apart is its utilization of a distinctive antibody that selectively targets the C3d region of the alpha chain. This way it specifically distinguishes between native and activated C3 proteins. \u003c\/li\u003e\n\u003cli\u003eThis ELISA can aid in advancing treatment options for various diseases such as transplantation rejection, kidney diseases, age-related macular degeneration (AMD) and inflammatory diseases\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614112538915,"sku":"HYBHK301702","price":2411.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ec6eb230-fa21-4d2a-9a90-f826014c8022.png?v=1753030242"},{"product_id":"complement-factor-h-human-elisa-kit-1-x-96-det","title":"FH\/FHR-1, Human, ELISA kit. 1 x 96 det.","description":"\u003cp class=\"richp\"\u003eThe human complement FH\/FHR-1 ELISA kit is to be used for the in vitro quantitative determination of human complement factor H in plasma, serum, and urine samples.\u003c\/p\u003e\u003cp class=\"richp\"\u003eComplement Factor H (CFH) is key in the complement system, vital for immune defense and inflammation control. With a robust presence in the bloodstream at 400-800 µg\/ml, CFH stabilizes complement activity, targeting immune responses. It binds C3b, speeding up alternative pathway C3-convertase breakdown and aiding C3b deactivation, thereby shielding the body from undue tissue damage.\u003c\/p\u003e\u003cp class=\"richp\"\u003eCFH’s structure, a 150 kDa glycoprotein with 20 consensus repeats, is crucial for its function. These repeats have sites essential for CFH’s anti-inflammatory role and CRP interaction, affecting cell signaling. CFH’s N-terminal and C-terminal domains, notably SCR 7, are key in fluid regulation and cellular defense. The link between CFH gene variations and a spectrum of human diseases, including kidney disorders like atypical Hemolytic Uremic Syndrome (aHUS) and vision-threatening conditions like age-related macular degeneration (AMD), underscore its clinical relevance and the potential for targeted CFH-based therapies.\u003c\/p\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114013475,"sku":"HYBHK34201","price":1379.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/hycult_elisa_kit_2048x2048pxl.jpg?v=1777496309"},{"product_id":"complement-factor-h-human-elisa-kit-2-x-96-det","title":"FH\/FHR-1, Human, ELISA kit, 2 x 96 det.","description":"\u003cp class=\"richp\"\u003eThe human complement FH\/FHR-1 ELISA kit is to be used for the in vitro quantitative determination of human complement factor H in plasma, serum, and urine samples.\u003c\/p\u003e\u003cp class=\"richp\"\u003eComplement Factor H (CFH) is key in the complement system, vital for immune defense and inflammation control. With a robust presence in the bloodstream at 400-800 µg\/ml, CFH stabilizes complement activity, targeting immune responses. It binds C3b, speeding up alternative pathway C3-convertase breakdown and aiding C3b deactivation, thereby shielding the body from undue tissue damage.\u003c\/p\u003e\u003cp class=\"richp\"\u003eCFH’s structure, a 150 kDa glycoprotein with 20 consensus repeats, is crucial for its function. These repeats have sites essential for CFH’s anti-inflammatory role and CRP interaction, affecting cell signaling. CFH’s N-terminal and C-terminal domains, notably SCR 7, are key in fluid regulation and cellular defense. The link between CFH gene variations and a spectrum of human diseases, including kidney disorders like atypical Hemolytic Uremic Syndrome (aHUS) and vision-threatening conditions like age-related macular degeneration (AMD), underscore its clinical relevance and the potential for targeted CFH-based therapies.\u003c\/p\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114046243,"sku":"HYBHK34202","price":2271.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/hycult_elisa_kit_2048x2048pxl_27edc5e2-0960-46d6-919c-e38081087f96.jpg?v=1777496314"},{"product_id":"complement-factor-d-human-elisa-kit-1-x-96-det","title":"Complement Factor D, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe alternative pathway of complement represents an important humoral component of natural defense against microbial attack. The interaction of the proteins C3, factor B, and factor D results in the formation of the alternative C3- and C5-convertases, i.e. C3bBb and C3bBbC3b(n). These multicomponent enzymes assemble on the surface of alternative pathway of complement activators and are stabilized by properdin (P). The participation of the alternative pathway of complement has been implicated in the pathogenesis of a wide variety of human diseases.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114111779,"sku":"HYBHK34301","price":1324.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4da4b235-4f30-4ced-8725-fdfce61808a6.png?v=1753030366"},{"product_id":"complement-factor-d-human-elisa-kit-2-x-96-det","title":"Complement Factor D, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe alternative pathway of complement represents an important humoral component of natural defense against microbial attack. The interaction of the proteins C3, factor B, and factor D results in the formation of the alternative C3- and C5-convertases, i.e. C3bBb and C3bBbC3b(n). These multicomponent enzymes assemble on the surface of alternative pathway of complement activators and are stabilized by properdin (P). The participation of the alternative pathway of complement has been implicated in the pathogenesis of a wide variety of human diseases.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114177315,"sku":"HYBHK34302","price":2043.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8554b34a-fde8-487b-a9dd-d4a7eb8d994b.png?v=1753030369"},{"product_id":"c3a-human-elisa-kit-1-x-96-det","title":"C3a, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. During complement activation, C3 is proteolytically cleaved resulting in release of the anaphylatoxic peptide C3a.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114504995,"sku":"HYBHK35401","price":1324.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ad48c757-8959-4cb6-8bb0-502b9a6b02c2.png?v=1753030403"},{"product_id":"c3a-human-elisa-kit-2-x-96-det","title":"C3a, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. During complement activation, C3 is proteolytically cleaved resulting in release of the anaphylatoxic peptide C3a.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114537763,"sku":"HYBHK35402","price":2043.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_92775299-2364-48f6-a7af-5303bd4cae63.png?v=1753030406"},{"product_id":"complement-factor-i-human-elisa-kit-1-x-96-det","title":"Complement factor I, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eStandard range Measurable concentration range of 35.1 to 400 ng\/ml.\u003c\/li\u003e\n\u003cli\u003eDetection level Minimum concentration which can be measured is 35.1 ng\/ml.\u003c\/li\u003e\n\u003cli\u003eWorking volume 100 µl\/well\u003c\/li\u003e\n\u003cli\u003eSpecies Human\u003c\/li\u003e\n\u003cli\u003eCross reactivity Mouse - No, Pig - No, Rat - No\u003c\/li\u003e\n\u003cli\u003eAlias CFI, C3b-Inactivator, C3b\/C4b inactivator, Konglutinogen-Activating Factor\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114570531,"sku":"HYBHK35501","price":1379.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ad68b7e7-c2b0-4e20-999c-da749f1d9385.png?v=1753030409"},{"product_id":"complement-factor-i-human-elisa-kit-2-x-96-det","title":"Complement factor I, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eStandard range Measurable concentration range of 35.1 to 400 ng\/ml.\u003c\/li\u003e\n\u003cli\u003eDetection level Minimum concentration which can be measured is 35.1 ng\/ml.\u003c\/li\u003e\n\u003cli\u003eWorking volume 100 µl\/well\u003c\/li\u003e\n\u003cli\u003eSpecies Human\u003c\/li\u003e\n\u003cli\u003eCross reactivity Mouse - No, Pig - No, Rat - No\u003c\/li\u003e\n\u003cli\u003eAlias CFI, C3b-Inactivator, C3b\/C4b inactivator, Konglutinogen-Activating Factor\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114603299,"sku":"HYBHK35502","price":2271.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_caba1ffe-76f3-4f91-9837-d0885b0e7f6e.png?v=1753030413"},{"product_id":"c1q-human-elisa-kit-1-x-96-det","title":"C1q, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eC1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. The formation of an antibody–antigen complex (immune complex) is the principal way of activating the classical pathway of the complement system. C1q triggers the activation process when it docks onto antibodies within these immune complexes. In this way, C1q acts to bridge the innate and adaptive immune systems. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto-antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defense and clearance of immune complexes. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE). In the case of C1q deficiency, SLE is found in 90% of reported cases. C1q plays a role in the prevention of autoimmunity by facilitating the physiological clearance and processing of apoptotic debris. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114636067,"sku":"HYBHK35601","price":1324.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ec33f405-562f-4611-b13c-cae467afbc47.png?v=1753030416"},{"product_id":"c1q-human-elisa-kit-2-x-96-det","title":"C1q, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\u003cli\u003eC1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. The formation of an antibody–antigen complex (immune complex) is the principal way of activating the classical pathway of the complement system. C1q triggers the activation process when it docks onto antibodies within these immune complexes. In this way, C1q acts to bridge the innate and adaptive immune systems. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto-antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defense and clearance of immune complexes. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE). In the case of C1q deficiency, SLE is found in 90% of reported cases. C1q plays a role in the prevention of autoimmunity by facilitating the physiological clearance and processing of apoptotic debris. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114668835,"sku":"HYBHK35602","price":2043.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2dc2198b-e702-4e6d-98ec-ca06c991110f.png?v=1753030419"},{"product_id":"collectin-10-human-elisa-kit-1-x-96-det","title":"Collectin-10, Human, ELISA kit, 1 x 96 det.","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114767139,"sku":"HYBHK36401","price":1204.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1d0bacdb-580e-4636-9680-fbbb04d404be.png?v=1753030429"},{"product_id":"collectin-10-human-elisa-kit-2-x-96-det","title":"Collectin-10, Human, ELISA kit, 2 x 96 det.","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114799907,"sku":"HYBHK36402","price":1882.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_df22cf09-ddf8-40be-9b35-29daf064cc07.png?v=1753030433"},{"product_id":"c3-human-elisa-kit-1-x-96-det","title":"C3, Human, ELISA kit, 1 x 96 det.","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114832675,"sku":"HYBHK36601","price":1324.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_00eb96e8-ca42-400e-a4cb-6694d6cab49d.png?v=1753030436"},{"product_id":"c3-human-elisa-kit-2-x-96-det","title":"C3, Human, ELISA kit, 2 x 96 det.","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114865443,"sku":"HYBHK36602","price":2043.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8e4cccaa-6f97-4712-8850-2a9e189b6c00.png?v=1753030440"},{"product_id":"c3c-human-elisa-kit-1-x-96-det","title":"C3c, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe complement system mediates a number of essential biological functions that participate in host defense against infection, initiation of the inflammatory reaction, processing and clearance of immune complexes and regulation of the immune response. There are three pathways of complement activation: the classical pathway is initiated by immune complexes, the lectin pathway by surface bound mannan binding lectin and the alternative pathway by all the surfaces that are not specifically protected against it. Each complement pathway generates a C3 convertase, a serine protease that cleaves the central complement protein C3, and generates the major cleavage fragment C3b. C3b is an opsonin and part of one of the main convertases that drives the complement cascade. In the presence of complement regulatory molecules C3b may be further degraded sequentially to iC3b, C3c, C3dg and C3d. The disadvantage of most complement biomarkers is their short half-life, making reliable sample collection and measurements difficult. Unlike other C3 fragments, C3c does not bind to other structures like pathogens, cell surface (receptors) and other plasma proteins. Therefore, C3c is a stable complement biomarker which will appear in the fluid phase only, without interference of other C3 based products. The measurement of C3c provides evidence of (uncontrolled) complement activation and can be used as an indicator of an inflammatory state. The complement is a key element of the innate immune system. Inappropriate activation is pathologic and leads for example to various autoimmune diseases (e.g. HUS). There are also indications that C3 is associated with the cardiovascular system and Parkinson’s disease, making C3c a reliable and useful biomarker.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114963747,"sku":"HYBHK36801","price":1379.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_03530362-a182-4c1a-a249-4419f5ecc414.png?v=1753030449"},{"product_id":"c3c-human-elisa-kit-2-x-96-det","title":"C3c, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe complement system mediates a number of essential biological functions that participate in host defense against infection, initiation of the inflammatory reaction, processing and clearance of immune complexes and regulation of the immune response. There are three pathways of complement activation: the classical pathway is initiated by immune complexes, the lectin pathway by surface bound mannan binding lectin and the alternative pathway by all the surfaces that are not specifically protected against it. Each complement pathway generates a C3 convertase, a serine protease that cleaves the central complement protein C3, and generates the major cleavage fragment C3b. C3b is an opsonin and part of one of the main convertases that drives the complement cascade. In the presence of complement regulatory molecules C3b may be further degraded sequentially to iC3b, C3c, C3dg and C3d. The disadvantage of most complement biomarkers is their short half-life, making reliable sample collection and measurements difficult. Unlike other C3 fragments, C3c does not bind to other structures like pathogens, cell surface (receptors) and other plasma proteins. Therefore, C3c is a stable complement biomarker which will appear in the fluid phase only, without interference of other C3 based products. The measurement of C3c provides evidence of (uncontrolled) complement activation and can be used as an indicator of an inflammatory state. The complement is a key element of the innate immune system. Inappropriate activation is pathologic and leads for example to various autoimmune diseases (e.g. HUS). There are also indications that C3 is associated with the cardiovascular system and Parkinson’s disease, making C3c a reliable and useful biomarker.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114996515,"sku":"HYBHK36802","price":2271.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_70a80b76-e44a-4838-a086-c422120d9596.png?v=1753030453"},{"product_id":"coagulation-factor-xii-human-elisa-kit-1-x-96-det","title":"Coagulation factor XII, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eFXII is a serine protease and plays a role in blood coagulation, fibrinolysis, kinin and complement systems. The protein is the zymogen of the serine protease factor XIIa (FXIIa). FXII is converted to FXIIa through autoactivation induced by contact to charged surfaces, also known as the plasma contact system. \u003c\/li\u003e\n\u003cli\u003eStandard range Measurable concentration range of 0.8 to 50 ng\/ml.\u003c\/li\u003e\n\u003cli\u003eSpecies Human\u003c\/li\u003e\n\u003cli\u003eCross reactivity Mouse - No, Pig - No, Rat - No\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614115094819,"sku":"HYBHK37301","price":1324.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_203b452e-94f9-4e2a-833d-431728259b72.png?v=1753030463"},{"product_id":"coagulation-factor-xii-human-elisa-kit-2-x-96-det","title":"Coagulation factor XII, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eFXII is a serine protease and plays a role in blood coagulation, fibrinolysis, kinin and complement systems. The protein is the zymogen of the serine protease factor XIIa (FXIIa). 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