{"title":"14878-Complement Factor H","description":"","products":[{"product_id":"complement-factor-h-human-elisa-kit-1-x-96-det","title":"FH\/FHR-1, Human, ELISA kit. 1 x 96 det.","description":"\u003cp class=\"richp\"\u003eThe human complement FH\/FHR-1 ELISA kit is to be used for the in vitro quantitative determination of human complement factor H in plasma, serum, and urine samples.\u003c\/p\u003e\u003cp class=\"richp\"\u003eComplement Factor H (CFH) is key in the complement system, vital for immune defense and inflammation control. With a robust presence in the bloodstream at 400-800 µg\/ml, CFH stabilizes complement activity, targeting immune responses. It binds C3b, speeding up alternative pathway C3-convertase breakdown and aiding C3b deactivation, thereby shielding the body from undue tissue damage.\u003c\/p\u003e\u003cp class=\"richp\"\u003eCFH’s structure, a 150 kDa glycoprotein with 20 consensus repeats, is crucial for its function. These repeats have sites essential for CFH’s anti-inflammatory role and CRP interaction, affecting cell signaling. CFH’s N-terminal and C-terminal domains, notably SCR 7, are key in fluid regulation and cellular defense. The link between CFH gene variations and a spectrum of human diseases, including kidney disorders like atypical Hemolytic Uremic Syndrome (aHUS) and vision-threatening conditions like age-related macular degeneration (AMD), underscore its clinical relevance and the potential for targeted CFH-based therapies.\u003c\/p\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114013475,"sku":"HYBHK34201","price":1379.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/hycult_elisa_kit_2048x2048pxl.jpg?v=1777496309"},{"product_id":"complement-factor-h-human-elisa-kit-2-x-96-det","title":"FH\/FHR-1, Human, ELISA kit, 2 x 96 det.","description":"\u003cp class=\"richp\"\u003eThe human complement FH\/FHR-1 ELISA kit is to be used for the in vitro quantitative determination of human complement factor H in plasma, serum, and urine samples.\u003c\/p\u003e\u003cp class=\"richp\"\u003eComplement Factor H (CFH) is key in the complement system, vital for immune defense and inflammation control. With a robust presence in the bloodstream at 400-800 µg\/ml, CFH stabilizes complement activity, targeting immune responses. It binds C3b, speeding up alternative pathway C3-convertase breakdown and aiding C3b deactivation, thereby shielding the body from undue tissue damage.\u003c\/p\u003e\u003cp class=\"richp\"\u003eCFH’s structure, a 150 kDa glycoprotein with 20 consensus repeats, is crucial for its function. These repeats have sites essential for CFH’s anti-inflammatory role and CRP interaction, affecting cell signaling. CFH’s N-terminal and C-terminal domains, notably SCR 7, are key in fluid regulation and cellular defense. The link between CFH gene variations and a spectrum of human diseases, including kidney disorders like atypical Hemolytic Uremic Syndrome (aHUS) and vision-threatening conditions like age-related macular degeneration (AMD), underscore its clinical relevance and the potential for targeted CFH-based therapies.\u003c\/p\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614114046243,"sku":"HYBHK34202","price":2271.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/hycult_elisa_kit_2048x2048pxl_27edc5e2-0960-46d6-919c-e38081087f96.jpg?v=1777496314"}],"url":"https:\/\/chromspec.com\/collections\/14878-complement-factor-h.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}