{"title":"14880-Human Elisa Kits E","description":"","products":[{"product_id":"elafin-human-elisa-kit-1-x-96-det","title":"Elafin, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eElafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2 in a recent classification. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and in addition it is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including those of hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. The full-length protein is translated as a 12.3 kDa protein of 117 amino acids termed pre-elafin or Trappin-2. Cleavage of the signal peptide yields a mature protein with a molecular mass of 9.9 kDa. The 9.9 kDa secreted protein is the major form found in culture medium. In skin extracts a 6 kDa form comprising the 57 most C-terminal amino acids is present, which is the form of elafin originally described by Wiedow et al. In serum both the 9.9 and the 6 kDa form appear to be present. In urine only the short 6 kDa form is found. The Hycult biotech ELISA is not suitable to measure the short 6 kDa form. Elafin has been used as a quantitative marker for disease activity in severe psoriasis during treatment with cyclosporin. In serum\/plasma of healthy individuals approximately 10-50 ng\/ml elafin is present. Elafin shows a 10-fold increase in concentration during psoriasis. The determination of Elafin is not disturbed by the presence of the short 6 kDa form.\u003c\/li\u003e\n\u003cli\u003eThe human elafin ELISA has been developed for the quantitative measurement of natural and recombinant elafin in serum, plasma and cell culture medium. In serum or plasma samples elafin can be measured accurately if serum or plasma samples are diluted at least 10 times.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614112833827,"sku":"HYBHK31801","price":1379.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_31ea7b6c-36af-4492-a062-603f794ffb2d.png?v=1753030269"},{"product_id":"elafin-human-elisa-kit-2-x-96-det","title":"Elafin, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eElafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2 in a recent classification. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and in addition it is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including those of hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. The full-length protein is translated as a 12.3 kDa protein of 117 amino acids termed pre-elafin or Trappin-2. Cleavage of the signal peptide yields a mature protein with a molecular mass of 9.9 kDa. The 9.9 kDa secreted protein is the major form found in culture medium. In skin extracts a 6 kDa form comprising the 57 most C-terminal amino acids is present, which is the form of elafin originally described by Wiedow et al. In serum both the 9.9 and the 6 kDa form appear to be present. In urine only the short 6 kDa form is found. The Hycult biotech ELISA is not suitable to measure the short 6 kDa form. Elafin has been used as a quantitative marker for disease activity in severe psoriasis during treatment with cyclosporin. In serum\/plasma of healthy individuals approximately 10-50 ng\/ml elafin is present. Elafin shows a 10-fold increase in concentration during psoriasis. The determination of Elafin is not disturbed by the presence of the short 6 kDa form.\u003c\/li\u003e\n\u003cli\u003eThe human elafin ELISA has been developed for the quantitative measurement of natural and recombinant elafin in serum, plasma and cell culture medium. In serum or plasma samples elafin can be measured accurately if serum or plasma samples are diluted at least 10 times.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614112866595,"sku":"HYBHK31802","price":2271.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5a21f4f9-cc74-4bf6-954a-7b9a0a5cb310.png?v=1753030272"},{"product_id":"elastase-human-elisa-kit-1-x-96-det","title":"Elastase, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eNeutrophil elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition, mucosa secretions may contain the locally secreted elastase inhibitors elafin\/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4. In plasma of healthy individuals approx. 55 ng\/ml (29 - 86 ng\/ml) elastase is present.\u003c\/li\u003e\n\u003cli\u003eThe human neutrophil elastase ELISA has been developed for the quantitative measurement of free and bound natural human neurophil elastase in cell culture medium and plasma.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614112899363,"sku":"HYBHK31901","price":1324.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_22a784f4-4d78-420f-a632-219a17b26ff5.png?v=1753030276"},{"product_id":"elastase-human-elisa-kit-2-x-96-det","title":"Elastase, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eNeutrophil elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition, mucosa secretions may contain the locally secreted elastase inhibitors elafin\/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4. In plasma of healthy individuals approx. 55 ng\/ml (29 - 86 ng\/ml) elastase is present.\u003c\/li\u003e\n\u003cli\u003eThe human neutrophil elastase ELISA has been developed for the quantitative measurement of free and bound natural human neurophil elastase in cell culture medium and plasma.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614112932131,"sku":"HYBHK31902","price":2043.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f459cd8b-3fb6-4f39-879c-10955ce77587.png?v=1753030279"},{"product_id":"edn-human-elisa-kit-1-x-96-det","title":"EDN, Human, ELISA kit, 1 x 96 det.","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614115848483,"sku":"HYBHK39101","price":1204.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f4a58660-12aa-49aa-bd36-c195875c17d2.png?v=1753030391"},{"product_id":"edn-human-elisa-kit-2-x-96-det","title":"EDN, Human, ELISA kit, 2 x 96 det.","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614115881251,"sku":"HYBHK39102","price":1882.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e08e12a8-8acd-48f4-a61f-a9319cbdbd18.png?v=1753030395"},{"product_id":"endocab-igg-iga-and-igm-human-elisa-kit-3-x-96-det","title":"EndoCab IgG, IgA and IgM , Human, ELISA kit, 3 x 96 det.","description":"\u003cp\u003eContains three EndoCab® ELISA kits: EndoCab® IgA, Human, ELISA kit; EndoCab® IgG, Human, ELISA kit; EndoCab® IgM, Human, ELISA kit\u003c\/p\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614116405539,"sku":"HYBHK504AGM","price":2980.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_7e2e4f1e-c3db-45bb-8cf4-815df35dda79.png?v=1753030448"},{"product_id":"endocab-iga-human-elisa-kit-1-x-96-det","title":"EndoCab IgA, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe EndoCab® IgA ELISA has been developed for determination of endotoxin core\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614116438307,"sku":"HYBHK504IGA","price":1493.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_47f3183c-f86b-408c-917d-b17f816804d2.png?v=1753030451"},{"product_id":"endocab-igg-human-elisa-kit-1-x-96-det","title":"EndoCab IgG, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe EndoCab® IgG ELISA has been developed for determination of endotoxin core antibodies in human plasma or serum in patients or healthy individuals. Several studies show a consistent drop in postoperative levels of circulating anti-endotoxin core antibodies compared to the preoperative value. This drop has been interpreted as consumption of antibodies to endotoxin by systemic release of endotoxin. A hypothesis is that if the patients pre-operative endotoxin-core level is low, even moderately low, patients may not be able to cope with the efflux of endotoxin, which may have mild to severe clinical consequences. The assay is of interest for various experimental conditions ranging from in vitro LPS neutralization by plasma components to in vivo studies on kinetics of antibodies to endotoxin in health and diseases.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614116471075,"sku":"HYBHK504IGG","price":1493.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2f566035-7439-4ed9-acf7-3408019fbbe0.png?v=1753030455"},{"product_id":"endocab-igm-human-elisa-kit-1-x-96-det","title":"EndoCab IgM, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eThe EndoCab® IgM ELISA has been developed for determination of endotoxin core antibodies in human plasma or serum in patients or healthy individuals. Several studies show a consistent drop in postoperative levels of circulating anti-endotoxin core antibodies compared to the preoperative value. This drop has been interpreted as consumption of antibodies to endotoxin by systemic release of endotoxin. A hypothesis is that if the patients pre-operative endotoxin-core level is low, even moderately low, patients may not be able to cope with the efflux of endotoxin, which may have mild to severe clinical consequences. The assay is of interest for various experimental conditions ranging from in vitro LPS neutralization by plasma components to in vivo studies on kinetics of antibodies to endotoxin in health and diseases.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614116503843,"sku":"HYBHK504IGM","price":1493.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_fac013ee-d7a8-447b-bd05-ac84fe91e72d.png?v=1753030458"}],"url":"https:\/\/chromspec.com\/collections\/14880-human-elisa-kits-e.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}