{"title":"14898-Ficolin-3","description":"","products":[{"product_id":"ficolin-3-human-elisa-kit-1-x-96-det","title":"Ficolin-3, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eFicolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain. Three forms of Ficolin have been identified in humans: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin) and Ficolin-3 (H-ficolin 3). Ficolin-3, also known as Hakata-antigen or H-ficolin, is composed by a collagen-like strand and three C-terminal recognition domains which bind to acetyl groups on microbial surfaces such as GlcNAc or GalNAc. Ficolin-3 is synthesized both in the liver, from where it is secreted into the blood circulation, and in the lung. Similar to MBL and Ficolin-2, Ficolin-3 relies on MBL-associated serine protease 2 (MASP-2) for activation of the complement system. After binding of Ficolin-3\/MASP-2 complexes to microbial surfaces, MASP-2 sequentially cleaves C4 and C2, thereby generating the C3 convertase C4bC2b, which finally leads to opsonization and direct lysis of pathogens and recruitment of inflammatory cells.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614113947939,"sku":"HYBHK34001","price":1204.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f5a70e29-bbc6-416f-9af7-aa46be4b25f1.png?v=1753030370"},{"product_id":"ficolin-3-human-elisa-kit-2-x-96-det","title":"Ficolin-3, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\u003cli\u003eFicolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain. Three forms of Ficolin have been identified in humans: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin) and Ficolin-3 (H-ficolin 3). Ficolin-3, also known as Hakata-antigen or H-ficolin, is composed by a collagen-like strand and three C-terminal recognition domains which bind to acetyl groups on microbial surfaces such as GlcNAc or GalNAc. Ficolin-3 is synthesized both in the liver, from where it is secreted into the blood circulation, and in the lung. Similar to MBL and Ficolin-2, Ficolin-3 relies on MBL-associated serine protease 2 (MASP-2) for activation of the complement system. After binding of Ficolin-3\/MASP-2 complexes to microbial surfaces, MASP-2 sequentially cleaves C4 and C2, thereby generating the C3 convertase C4bC2b, which finally leads to opsonization and direct lysis of pathogens and recruitment of inflammatory cells.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614113980707,"sku":"HYBHK34002","price":1882.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_01cd805b-1e2c-4e10-ae70-260b53ee1931.png?v=1753030373"}],"url":"https:\/\/chromspec.com\/collections\/14898-ficolin-3.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}