{"title":"14901-Human Elisa Kits H","description":"","products":[{"product_id":"hnp1-3-human-elisa-kit-1-x-96-det","title":"HNP1-3, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eHuman neutrophil defensins (alpha-defensins, HNP1-3) belong to the family of cationic trisulfide-containing microbicidal peptides. Besides microbicidal, the peptides exert chemotactic, immunomodulating and cytotoxic activity and participate in host defense and inflammation. Azurophilic granules of neutrophils contain Human Neutrophil Peptide (HNP)-1-4 which are highly homologous. The three principal human defensins, HNP 1-3, are unique to neutrophils and account for about 99 percent of the total defensin content of these cells. Measured amount of defensins is 3-5 mg per million human neutrophils. Activation of neutrophils leads to rapid release of defensins. Thus, only one cell type, neutrophils, may be the source of HNP1-3 measured in plasma and other body fluids during infection and inflammation. In normal plasma low levels of HNP are present ranging from undetectable level to 50-100 ng\/ml, while in septic conditions the levels of HNP might be elevated to 10 mg\/ml and even more. Activation of neutrophils in blood as occurs during clotting, as well as long storage of anticoagulated blood leads to a release of HNP, thus careful plasma sampling is important for possible detection of HNP. Defensins are relatively resistant to proteolysis, low pH and boiling, but have a tendency to bind to a variety of materials, including plastic and proteins. The HNP 1-3 ELISA shows cross reactivity with Rhesus monkey HNP 1-3.\u003c\/li\u003e\n\u003cli\u003eThe human HNP1-3 ELISA has been developed for the quantitative measurement of natural and recombinant human HNP1-3 in cell culture medium, plasma and other biological fluids. In plasma samples human HNP1-3 can be measured accurately if plasma samples are diluted at least 2000 times for human and at least 4x for Rhesus monkey.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614112768291,"sku":"HYBHK31701","price":1379.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_446e648f-6f2a-47dd-8935-03dae8e0e40d.png?v=1753030262"},{"product_id":"hnp1-3-human-elisa-kit-2-x-96-det","title":"HNP1-3, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eHuman neutrophil defensins (alpha-defensins, HNP1-3) belong to the family of cationic trisulfide-containing microbicidal peptides. Besides microbicidal, the peptides exert chemotactic, immunomodulating and cytotoxic activity and participate in host defense and inflammation. Azurophilic granules of neutrophils contain Human Neutrophil Peptide (HNP)-1-4 which are highly homologous. The three principal human defensins, HNP 1-3, are unique to neutrophils and account for about 99 percent of the total defensin content of these cells. Measured amount of defensins is 3-5 mg per million human neutrophils. Activation of neutrophils leads to rapid release of defensins. Thus, only one cell type, neutrophils, may be the source of HNP1-3 measured in plasma and other body fluids during infection and inflammation. In normal plasma low levels of HNP are present ranging from undetectable level to 50-100 ng\/ml, while in septic conditions the levels of HNP might be elevated to 10 mg\/ml and even more. Activation of neutrophils in blood as occurs during clotting, as well as long storage of anticoagulated blood leads to a release of HNP, thus careful plasma sampling is important for possible detection of HNP. Defensins are relatively resistant to proteolysis, low pH and boiling, but have a tendency to bind to a variety of materials, including plastic and proteins. The HNP 1-3 ELISA shows cross reactivity with Rhesus monkey HNP 1-3.\u003c\/li\u003e\n\u003cli\u003eThe human HNP1-3 ELISA has been developed for the quantitative measurement of natural and recombinant human HNP1-3 in cell culture medium, plasma and other biological fluids. In plasma samples human HNP1-3 can be measured accurately if plasma samples are diluted at least 2000 times for human and at least 4x for Rhesus monkey.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614112801059,"sku":"HYBHK31702","price":2271.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_bfaa7e85-f879-4452-b42d-bff540589bb7.png?v=1753030265"},{"product_id":"h-fabp-human-elisa-kit-1-x-96-det","title":"H-FABP, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eFatty acid-binding proteins (FABPs) are a class of cytoplasmic proteins that bind long chain fatty acids. FABPs are small intracellular proteins (~13-14 kDa) with a high degree of tissue specificity. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of ischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. Following acute myocardial infarction (AMI) the small protein H-FABP is rapidly released into the circulation. H-FABP is derived from the human FABP3 gene. Significantly elevated serum\/plasma concentrations are found within 3 h after AMI which generally return to normal values within 12 to 24 h. These features make H-FABP a useful research tool for the early assessment or exclusion of AMI, and for the monitoring of a recurrent infarction. Constitutive H-FABP released from the heart after AMI is quantitatively recovered in serum\/plasma. Thus assessment of H-FABP is also a very effective tool for the estimation of the infarct size. The human H-FABP kit can also be used for measurement of brain-type FABP, a marker for brain injury detection and for measurement of muscle-type cytosolic fatty acid binding protein (FABPc) in skeletal muscle. In serum\/plasma of healthy individuals approximately 1.6 ng\/ml of H-FABP is present. H-FABP shows a slight increase with age.\u003c\/li\u003e\n\u003cli\u003eThe human H-FABP ELISA has been developed for the quantitative measurement of natural human H-FABP in serum, plasma and urine.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614116110627,"sku":"HYBHK401","price":1324.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_115ec90a-bbce-431b-9b38-7b656d173640.png?v=1753030418"},{"product_id":"h-fabp-human-elisa-kit-2-x-96-det","title":"H-FABP, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eFatty acid-binding proteins (FABPs) are a class of cytoplasmic proteins that bind long chain fatty acids. FABPs are small intracellular proteins (~13-14 kDa) with a high degree of tissue specificity. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of ischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. Following acute myocardial infarction (AMI) the small protein H-FABP is rapidly released into the circulation. H-FABP is derived from the human FABP3 gene. Significantly elevated serum\/plasma concentrations are found within 3 h after AMI which generally return to normal values within 12 to 24 h. These features make H-FABP a useful research tool for the early assessment or exclusion of AMI, and for the monitoring of a recurrent infarction. Constitutive H-FABP released from the heart after AMI is quantitatively recovered in serum\/plasma. Thus assessment of H-FABP is also a very effective tool for the estimation of the infarct size. The human H-FABP kit can also be used for measurement of brain-type FABP, a marker for brain injury detection and for measurement of muscle-type cytosolic fatty acid binding protein (FABPc) in skeletal muscle. In serum\/plasma of healthy individuals approximately 1.6 ng\/ml of H-FABP is present. H-FABP shows a slight increase with age.\u003c\/li\u003e\n\u003cli\u003eThe human H-FABP ELISA has been developed for the quantitative measurement of natural human H-FABP in serum, plasma and urine.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614116143395,"sku":"HYBHK402","price":2043.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_03d18a0c-b296-46c4-bac3-5ce4967716ee.png?v=1753030421"}],"url":"https:\/\/chromspec.com\/collections\/14901-human-elisa-kits-h.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}