{"title":"14912-Human Elisa Kits M","description":"","products":[{"product_id":"mbl-human-elisa-kit-1-x-96-det","title":"MBL, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eMannose Binding Lectin (MBL) is a C-type lectin that is an important element in innate immunity. MBL belongs to the collectin family of proteins that consists of a collagen-like domain and a carbohydrate recognition domain (CRD). Through this, MBL recognizes carbohydrates (e.g. mannose and N-acetylglucosamine) on pathogens. MBL forms several sizes of oligomers that are composed of subunits of three identical 32 kDa polypeptides. MBL is a pattern recognition receptor, and upon recognition of the infectious agent, MBL triggers the activation of the lectin-complement pathway through attached C1r\/C1s-like serine proteases, designated MASP. The MBL-MASP complex proteolytically cleaves C4, C2 and C3. The lectin pathway is antibody and C1q-independent and is, therefore, independent of the classical and alternative complement activation pathway. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Normal human plasma contains MBL concentrations ranging from 10 to 5,000 ng\/ml. Up to 12% of healthy Caucasian blood donors have MBL concentrations below 100 ng\/ml. Low plasma concentrations have been associated with an inherited defect in opsonization. The MBL concentration is enhanced in infectious diseases. Measuring of MBL is indicated in recurrent infections (especially in children), primary\/secondary immunodeficiencies, artherosclerosis\/coronary heart disease, cystic fibrosis, transplantation, autoimmune diseases (SLE\/Rheumatoid arthritis) and habitual abortion. MBL measurement is not affected by the presence of antibodies against mannan. In the human MBL assay, any influence of the classical pathway has been eliminated by using a special MBL-binding buffer, which inhibits the binding of C1q to immunocomplexes and disrupts the C1 complex, while leaving the function of the MBL complex intact.\u003c\/li\u003e\n\u003cli\u003eThe human MBL (Lectin assay) ELISA has been developed for the quantitative measurement of natural functional, mannan binding, human MBL in serum, plasma and culture medium.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614113095971,"sku":"HYBHK32301","price":1324.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e9c04e72-27a9-4d31-acf5-599253d98073.png?v=1753030296"},{"product_id":"mbl-human-elisa-kit-2-x-96-det","title":"MBL, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eMannose Binding Lectin (MBL) is a C-type lectin that is an important element in innate immunity. MBL belongs to the collectin family of proteins that consists of a collagen-like domain and a carbohydrate recognition domain (CRD). Through this, MBL recognizes carbohydrates (e.g. mannose and N-acetylglucosamine) on pathogens. MBL forms several sizes of oligomers that are composed of subunits of three identical 32 kDa polypeptides. MBL is a pattern recognition receptor, and upon recognition of the infectious agent, MBL triggers the activation of the lectin-complement pathway through attached C1r\/C1s-like serine proteases, designated MASP. The MBL-MASP complex proteolytically cleaves C4, C2 and C3. The lectin pathway is antibody and C1q-independent and is, therefore, independent of the classical and alternative complement activation pathway. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Normal human plasma contains MBL concentrations ranging from 10 to 5,000 ng\/ml. Up to 12% of healthy Caucasian blood donors have MBL concentrations below 100 ng\/ml. Low plasma concentrations have been associated with an inherited defect in opsonization. The MBL concentration is enhanced in infectious diseases. Measuring of MBL is indicated in recurrent infections (especially in children), primary\/secondary immunodeficiencies, artherosclerosis\/coronary heart disease, cystic fibrosis, transplantation, autoimmune diseases (SLE\/Rheumatoid arthritis) and habitual abortion. MBL measurement is not affected by the presence of antibodies against mannan. In the human MBL assay, any influence of the classical pathway has been eliminated by using a special MBL-binding buffer, which inhibits the binding of C1q to immunocomplexes and disrupts the C1 complex, while leaving the function of the MBL complex intact.\u003c\/li\u003e\n\u003cli\u003eThe human MBL (Lectin assay) ELISA has been developed for the quantitative measurement of natural functional, mannan binding, human MBL in serum, plasma and culture medium.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614113128739,"sku":"HYBHK32302","price":2043.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_68a11f4b-8b32-445b-b021-56128cc6fd25.png?v=1753030300"},{"product_id":"mpo-human-elisa-kit-1-x-96-det","title":"MPO, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\u003cli\u003eMyeloperoxidase (MPO) is a glycoprotein with a alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegener's disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614113161507,"sku":"HYBHK32401","price":1204.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9ea4b110-011b-47af-8a4e-60812f00b7e0.png?v=1753030303"},{"product_id":"mpo-human-elisa-kit-2-x-96-det","title":"MPO, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\u003cli\u003eMyeloperoxidase (MPO) is a glycoprotein with a alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegener's disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614113194275,"sku":"HYBHK32402","price":1882.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b04c3d8d-4696-4efc-89f1-5c9e792924f0.png?v=1753030307"},{"product_id":"masp-2-human-elisa-kit-1-x-96-det","title":"MASP-2, Human, ELISA kit, 1 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eMASP-2 is a MBL associated serine protease. Mannan-binding lectin (MBL) and ficolins, in complex with MASPs, are capable of activating the complement system, thus mediating the destruction of infectious agents. After oligomerisation of MBL (or L-Ficolin) MASP-2 will be bound and activated. Activated MASP-2 cleaves C4 and C2 and is crucial for the activation of downstream complement components. MASP-2 deficiency will result in an increased susceptibility for infections (e.g. leukemia patients in chemotherapy are at high risk of serious infections). Even more so then MBL deficiency, because MASP-2 is also required for complement activation by H- and L-ficolin. The ELISA detects MASP-2 in serum and plasma. The MASP-2 levels in plasma from healthy individuals range from 170 to 1196 ng\/ml.\u003c\/li\u003e\n\u003cli\u003eThe human MASP-2 ELISA has been developed for the quantitative measurement of natural human MASP-2 in cell culture medium, plasma and serum.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614113259811,"sku":"HYBHK32601","price":1493.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9d7d877d-8424-486b-8712-7b6679bb56b2.png?v=1753030310"},{"product_id":"masp-2-human-elisa-kit-2-x-96-det","title":"MASP-2, Human, ELISA kit, 2 x 96 det.","description":"\u003cul\u003e\n\u003cli\u003eMASP-2 is a MBL associated serine protease. Mannan-binding lectin (MBL) and ficolins, in complex with MASPs, are capable of activating the complement system, thus mediating the destruction of infectious agents. After oligomerisation of MBL (or L-Ficolin) MASP-2 will be bound and activated. Activated MASP-2 cleaves C4 and C2 and is crucial for the activation of downstream complement components. MASP-2 deficiency will result in an increased susceptibility for infections (e.g. leukemia patients in chemotherapy are at high risk of serious infections). Even more so then MBL deficiency, because MASP-2 is also required for complement activation by H- and L-ficolin. The ELISA detects MASP-2 in serum and plasma. The MASP-2 levels in plasma from healthy individuals range from 170 to 1196 ng\/ml.\u003c\/li\u003e\n\u003cli\u003eThe human MASP-2 ELISA has been developed for the quantitative measurement of natural human MASP-2 in cell culture medium, plasma and serum.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614113325347,"sku":"HYBHK32602","price":2411.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a02a41cc-f308-4ba3-985d-9d53df7146cb.png?v=1753030313"},{"product_id":"human-mitochondrial-open-reading-frame-of-the-12s-rrna-c-mots-c-elisa-kit-48-tests","title":"***Human Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) ELISA Kit, 48 Tests","description":"\u003cp\u003eThis assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mitochondrial Open Reading Frame Of The 12S rRNA-c(MOTS-c) protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mitochondrial Open Reading Frame Of The 12S rRNA-c(MOTS-c).\u003c\/p\u003e","brand":"Biorbyt","offers":[{"title":"Default Title","offer_id":54850555805987,"sku":"ORB78146948TEST","price":536.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Biorbyt_elisa_kits_and_assays_2048x2048pxl_7c380d45-e2e7-477c-b474-e651e7c2e29f.jpg?v=1774302300"},{"product_id":"human-mitochondrial-open-reading-frame-of-the-12s-rrna-c-mots-c-elisa-kit-96-tests","title":"***Human Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) ELISA Kit, 96 Tests","description":"\u003cp class=\"richp\"\u003eThis assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mitochondrial Open Reading Frame Of The 12S rRNA-c(MOTS-c) protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mitochondrial Open Reading Frame Of The 12S rRNA-c(MOTS-c).\u003c\/p\u003e","brand":"Biorbyt","offers":[{"title":"Default Title","offer_id":54850555904291,"sku":"ORB78146996TEST","price":747.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Biorbyt_elisa_kits_and_assays_2048x2048pxl_65ff8d6a-ae9a-4da8-b6c0-19ef56b80fd7.jpg?v=1774302305"}],"url":"https:\/\/chromspec.com\/collections\/14912-human-elisa-kits-m.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}