{"title":"14955-Antibody Name A","description":"","products":[{"product_id":"alpha-v-beta-3-integrin-human-mab-bv3","title":"alpha-V\/beta-3 Integrin, Human, mAb BV3","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody BV3 recognizes human alpha-V\/beta-3 integrin present on human cells. Integrins are a superfamily of αβ heterodimeric cell-surface adhesion receptors found in many species. They are expressed on a variety of cells and mediate numerous physiological processes, including inflammation, migration, adhesion and proliferation. The β3 family consist of 2 members: αIIbβ3 and αvβ3, which mediate cell-cell and cell-ECM interactions and are important for cellular migration, regulation of gene expression, cell survival, adhesion and differentiation. All processes which are involved in tissue development, angiogenesis and thrombosis. Each subunit consist of an extracellular domain, a single transmembrane segment and a cytoplasmic tail. They connect to the actin cytoskeleton via adaptor proteins that bind theircytoplasmic tails. Cell matrix adhesions also act as signaling units by their capacity to organize the actin cytoskeleton and to accumulate various signaling intermediates. Integrin αvβ3 was originally identified as the vitronectin receptor. Nevertheless, other ligands include fibrinogen, fibronectin, laminin, thrombospondin, Von Willebrand factor, tenascin, osteopontin and several forms of collagen. The interactions of integrin αvβ3 to those ligands is mediated by the RGD (Arg-Gly-Asp) sequence motif present in these proteins. Deregulation of β3 integrins is involved in e.g. autoimmune diseases, cardiovascular disorders, transplant rejection and tumorigenesis. In contribution to the latter, integrin αvβ3 contribute by supporting growth of small (tumor) blood vessels thereby potentiating the metastatic potential. Overexpression of integrin αvβ3 has been demonstrated in various tumors and activated endothelium. \u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Immunofluorescence , Immunoprecipitation , Paraffin Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135312675,"sku":"HYBHM2034100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5fe969e5-71d9-4da0-9db8-b9163671f6b1.png?v=1753031224"},{"product_id":"alpha-v-beta-3-integrin-human-mab-bv3-20-ug","title":"alpha-V\/beta-3 Integrin, Human, mAb BV3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135345443,"sku":"HYBHM203420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ff028e4f-5bb5-45e1-ab5f-729205d31e10.png?v=1753031227"},{"product_id":"activated-c1s-human-mab-m241","title":"Activated C1s, Human, mAb M241","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and\/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614141276451,"sku":"HYBHM2109100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e41b82ce-1193-48c7-be9d-fdbed83629c6.png?v=1753031459"},{"product_id":"activated-c1s-human-mab-m241-20-ug","title":"Activated C1s, Human, mAb M241, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614141309219,"sku":"HYBHM210920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_905cd4a0-ccd0-4a8f-8f6f-2e1dac4d3bc0.png?v=1753031462"},{"product_id":"alpha-5-integrin-fibronectin-receptor-human-mab-nki-sam1","title":"alpha-5 Integrin (Fibronectin-receptor), Human, mAb NKI-SAM1","description":"\u003cul\u003e\n\u003cli\u003eFibronectin receptor, also designated VLA-5, is a 130\/150 kDa protein. The protein functions as a receptor for fibronectin and mediates binding of B and T lymphocytes to fibronectin. Fibronectin is an extracellular matrix glycoprotein that functions in cell adhesion and migration in wound healing, embryonic development and malignant transformation. The fibronectin receptor is expressed on monocytes and monocytoid cell lines, leukocytes, memory T cells, fibroblasts, platelets and muscle cells.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614142456099,"sku":"HYBHM2126100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_aacd25ed-505d-4c58-bc81-fe1d9641f0c5.png?v=1753031546"},{"product_id":"alpha-5-integrin-fibronectin-receptor-human-mab-nki-sam1-20-ug","title":"alpha-5 Integrin (Fibronectin-receptor), Human, mAb NKI-SAM1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614142488867,"sku":"HYBHM212620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0801ea0c-8e30-4a37-8bc9-ba7eab0d144b.png?v=1753031549"},{"product_id":"arginase-1-human-mab-6g3","title":"Arginase 1, Human, mAb 6G3","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody 6G3 reacts specifically with Arginase I, the final enzyme in the urea cycle, which is responsible for the hydrolysis of arginine to urea and ornithine. The highest concentration of the enzyme is present in the liver in which the bulk of ureagenesis occurs. Two types of arginases are known: Arginase I and II. The cytosolic enzyme found primarily in liver is Arginase I, a 35 kD protein that circulates as trimer. Arginase II is exclusively located in the mitochondrion. Arginase I is next to the liver in man also expressed by mature fetal and adult red blood cells and activated monocytic cells. During inflammation induction of Arginase I by inflammatory cytokines in monocytic cells is considered to lead to a local depletion of arginine resulting in a microenvironment that prevents nitric oxide production and arginine dependent T cell function. Arginase II is expressed by kidney, nucleated red blood cells, brain, spinal cord, gastro-intestinal tract, mammary gland and prostate. Enhanced circulating Arginase I levels have been reported after surgery, following haemorrhage and in asthmatic patients. Measurement of circulating Arginase I has been used experimentally as rapid marker for liver injury.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Immunoprecipitation\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144553251,"sku":"HYBHM2162100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c16bec2d-5c2a-4d09-b24c-87424192f433.png?v=1753031596"},{"product_id":"arginase-1-human-mab-6g3-20-ug","title":"Arginase 1, Human, mAb 6G3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144586019,"sku":"HYBHM216220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_704d8126-88bd-4846-8e12-df4328b4c80e.png?v=1753031600"},{"product_id":"arginase-1-human-mab-6g3-500-ug","title":"Arginase 1, Human, mAb 6G3, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144618787,"sku":"HYBHM2162500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2acdb8a3-df48-4bac-a70f-ff92df789e06.png?v=1753031603"},{"product_id":"arginase-1-human-mab-9c5","title":"Arginase 1, Human, mAb 9C5","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody 9C5 reacts specifically with Arginase I, the final enzyme in the urea cycle, which is responsible for the hydrolysis of arginine to urea and ornithine. The highest concentration of the enzyme is present in the liver in which the bulk of ureagenesis occurs. Two types of arginases are known: Arginase I and II. The cytosolic enzyme found primarily in liver is Arginase I, a 35 kD protein that circulates as trimer. Arginase II is exclusively located in the mitochondrion. Arginase I is next to the liver in man also expressed by mature fetal and adult red blood cells and activated monocytic cells. During inflammation induction of Arginase I by inflammatory cytokines in monocytic cells is considered to lead to a local depletion of arginine resulting in a microenvironment that prevents nitric oxide production and arginine dependent T cell function. Arginase II is expressed by kidney, nucleated red blood cells, brain, spinal cord, gastro-intestinal tract, mammary gland and prostate. Enhanced circulating Arginase I levels have been reported after surgery, following haemorrhage and in asthmatic patients. Measurement of circulating Arginase I has been used experimentally as rapid marker for liver injury.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Immunoprecipitation\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144651555,"sku":"HYBHM2163100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_fccca515-c185-4e38-804f-f978cef20939.png?v=1753031606"},{"product_id":"arginase-1-human-mab-9c5-20-ug","title":"Arginase 1, Human, mAb 9C5, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144684323,"sku":"HYBHM216320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_35a94883-0de4-4056-8a72-f516d5c30215.png?v=1753031609"},{"product_id":"arginase-1-human-mab-9c5-500-ug","title":"Arginase 1, Human, mAb 9C5, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144717091,"sku":"HYBHM2163500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6ee64891-a933-467d-ace0-7e99126e7783.png?v=1753031612"},{"product_id":"activated-c3-human-mab-bh6","title":"Activated C3, Human, mAb bH6","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody bH6 recognizes a neo-epitope expressed on the cleavage fragments of C3b, iC3b, and C3c. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. Monoclonal antibodies detecting neo-epitopes have been used for direct quantification of activation at different steps in the complement cascade. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg\/ml. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. In ulcerative colitis, and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by certain enzymes results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b, C3c, C3dg and C3f. The monoclonal antibody bH6 is specific for a C3 neo-epitope expressed on the cleavage fragments of C3b, iC3b, and C3c, but not C3dg and C3f.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunoassays , Paraffin Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614145175843,"sku":"HYBHM2168100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_de749365-aed0-4b2b-8a59-47b29a435ac6.png?v=1753031664"},{"product_id":"activated-c3-human-mab-bh6-20-ug","title":"Activated C3, Human, mAb bH6, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614145208611,"sku":"HYBHM216820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8c5d7d27-e1e6-41fe-a94e-1693d13a25b5.png?v=1753031667"},{"product_id":"adamts-13-human-mab-20a5","title":"ADAMTS-13, Human, mAb 20A5","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 20A5 recognizes human ADAMTS-13, A Disintegrin And Metalloprotease with ThromboSpondin type 1 domain 13. ADAMTS-13 is produced by hepatic stellate cells and in smaller amounts by human endothelial cells, and is present in plasma at a concentration of approximately 1 ug\/ml. ADAMTS-13 is a zinc-containing metalloprotease belonging to the ADAMTS family characterized by a protease domain, an adjacent disintegrin-like domain, one or more thrombospondin type 1 repeats, a cystein-rich domain and a typical spacer region. ADAMTS-13 is composed of a series of domains (amino to carboxy terminal): metalloprotease, disintegrin-like, central thrombospondin-1 (TSP-1), cysteine-rich, spacer, seven additional TSP-1 domains and two unique CUB domains. ADAMTS-13 has no hydrophobic transmembrane domain, and hence it is not anchored in the cell membrane. The apparent molecular weight is 170 or 190 kDa on non-reducing or reducing SDS-PAGE, respectively. ADAMTS-13 has an important function in haemostasis, where it catalyzes the cleavage of the peptide bond between tyrosine-1605 and methionine-1606 in the A2 domain of von Willebrand Factor (VWF), resulting in 2 electrophoretic reduced fragments of 176 and 140 kDa, respectively. This process renders large multimers less adhesive and hence less reactive in the setting of thrombus formation. ADAMTS-13 is therefore said to be a natural anti-thrombotic agent. Severe ADAMTS-13 deficiency is associated with systemic microvascular thrombosis in familial or acquired thrombotic thrombocytopenic purpura (TTP). The accumulation of non-cleaved large VWF multimers causes spontaneous systemic platelet aggregation blocking oxygen supply to vital organs. This life-threatening disorder can lead to ischemic disease with (multiple) organ failure. The monoclonal antibody 20A5 recognizes the central to C-terminal TSP-1 repeats 2 to 5 of ADAMTS-13 (amino acid 686-894).\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Immunofluorescence , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150746403,"sku":"HYBHM2226100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f611a91d-1e3d-4f67-ac24-e4f8e06a8aee.png?v=1753031798"},{"product_id":"adamts-13-human-mab-20a5-20-ug","title":"ADAMTS-13, Human, mAb 20A5, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150779171,"sku":"HYBHM222620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f28d12b8-bc11-4681-baee-26328186b975.png?v=1753031802"},{"product_id":"activated-c3-human-mab-i3-15","title":"Activated C3, Human, mAb I3\/15","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody I3\/15 recognizes activated complement protein C3, namely an neo-epitope on C3b, iC3b and C3dg which is not present in native C3. The antibody I3\/15 recognizes native C3 after unfolding upon activation or after SDS treatment. C3 is a 190 kD protein that plays an important role in the complement activation cascade. The molecule is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg\/ml. When activated, C3 is cleaved into two biologically active fragments known as C3a and C3b. C3a is a mediator of local inflammatory processes with anaphylatoxic properties. As such it induces smooth muscle contraction, increases vascular permeability, and causes histamine release from mast cells and basophilic leukocytes. C3b becomes attached to immune complexes and is further cleaved into iC3b, C3c, C3dg and C3f. The C3 fragments C3b, iC3b, C3dg and C3d are collectively termed activated C3 (act. C3). The most important function of C3 fragments is the interaction of the complement system with other immune cells. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. Monoclonal antibodies detecting neo-epitopes have been used for direct quantification of activation at different steps in the complement cascade.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614152581411,"sku":"HYBHM2257100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2a5c2c71-2c3d-4d16-8bbf-9a3c5ca3062c.png?v=1753031820"},{"product_id":"activated-c3-human-mab-i3-15-20-ug","title":"Activated C3, Human, mAb I3\/15, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614152614179,"sku":"HYBHM225720UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_60a20dd3-9dce-48b0-a33e-43c7c164f2d3.png?v=1753031823"},{"product_id":"alpha-1-antitrypsin-human-mab-2c1","title":"Alpha-1-antitrypsin, Human, mAb 2C1","description":"\u003cul\u003e\u003cli\u003eThe mouse monoclonal antibody clone 2C1 recognizes polymeric forms of human alpha-1-antitrypsin. Alpha-1-antitrypsin is the most abundant circulating protease inhibitor. Serpinopathies are conformational diseases characterized by the polymerization and intracellular retention of members of the serine protease inhibitor or serpin superfamily of proteins.1 The best known is a1-antitrypsin deficiency, with the most common severe deficiency allele being the Z mutation (Glu342Lys). The severe Z deficiency allele (Glu342Lys) causes the protein to undergo a conformational transition and form ordered polymers that are retained within hepatocytes. This causes neonatal hepatitis, cirrhosis, and hepatocellular carcinoma.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153924899,"sku":"HYBHM2289100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0583f8f9-36f4-47f9-bbd7-ff24b9749786.png?v=1753031958"},{"product_id":"alpha-1-antitrypsin-human-mab-2c1-20-ug","title":"Alpha-1-antitrypsin, Human, mAb 2C1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153957667,"sku":"HYBHM228920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0b53fc3b-59e1-47bd-a4e3-df0b776d6a5d.png?v=1753031961"},{"product_id":"alpha-1-antitrypsin-human-mab-2c1-500-ug","title":"Alpha-1-antitrypsin, Human, mAb 2C1, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153990435,"sku":"HYBHM2289500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0582bbe8-884d-4f56-bf42-12e5cb6e13b6.png?v=1753031965"},{"product_id":"azurocidin-human-mab-z6733-100-ug","title":"Azurocidin, Human, mAb #z6733, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody z6733 recognizes azurocidin (also called heparin-binding protein (HBP) or cationic antimicrobial protein of 37 Kda (CAP37). Azurocidin is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C.albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via β2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155071779,"sku":"HYBHM2311100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_17a6b2a0-cd41-41d7-a3a8-8d26b4105f0c.png?v=1753032054"},{"product_id":"azurocidin-human-mab-z6733","title":"Azurocidin, Human, mAb #z6733","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155104547,"sku":"HYBHM231120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_65903525-531c-43f8-aed4-72944bcaa35b.png?v=1753032058"},{"product_id":"azurocidin-human-mab-z6718","title":"Azurocidin, Human, mAb #z6718","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody z6718 recognizes azurocidin (also called heparin-binding protein (HBP) or cationic antimicrobial protein of 37 Kda (CAP37). Azurocidin is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C.albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via β2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunofluorescence , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155137315,"sku":"HYBHM2312100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_091f582b-1484-4af9-957e-b457e7481343.png?v=1753032061"},{"product_id":"azurocidin-human-mab-z6718-20-ug","title":"Azurocidin, Human, mAb #z6718, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155170083,"sku":"HYBHM231220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_653deb67-7d0f-43a9-a30a-a06ce8447832.png?v=1753032064"},{"product_id":"arginase-1-human-mab-d1-2","title":"Arginase 1, Human, mAb D1.2","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody D1.2 reacts specifically with Arginase I, the final enzyme in the urea cycle, whichis responsible for the hydrolysis of arginine to urea and ornithine. The highest concentration of theenzyme is present in the liver in which the bulk of ureagenesis occurs. Two types of arginases areknown: Arginase I and II. The cytosolic enzyme found primarily in liver is Arginase I, a 35 kD proteinthat circulates as trimer. Arginase II is exclusively located in the mitochondrion. Arginase I is next to theliver in man also expressed by mature fetal and adult red blood cells and activated monocytic cells.During inflammation induction of Arginase I by inflammatory cytokines in monocytic cells is consideredto lead to a local depletion of arginine resulting in a microenvironment that prevents nitric oxideproduction and arginine dependent T cell function. Arginase II is expressed by kidney, nucleated redblood cells, brain, spinal cord, gastro-intestinal tract, mammary gland and prostate. Enhancedcirculating Arginase I levels have been reported after surgery, following haemorrhage and in asthmaticpatients. Measurement of circulating Arginase I has been used experimentally as rapid marker for liverinjury.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155792675,"sku":"HYBHM2324100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e1ec7554-2190-4e7a-a513-b115b7aef7f1.png?v=1753031983"},{"product_id":"arginase-1-human-mab-d1-2-20-ug","title":"Arginase 1, Human, mAb D1.2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155825443,"sku":"HYBHM232420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_25552641-d383-4f1b-ae2a-c076c57389f6.png?v=1753031986"},{"product_id":"amyloid-beta-40-human-mab-vu-17","title":"Amyloid beta 40, Human, mAb VU-17","description":"\u003cul\u003e\u003cli\u003eAntibody clone VU17, formerly known as αVU Aß 17, recognizes the N-terminus of human amyloid beta (i.e. in: Aβ1-38; Aβ1-39; Aβ1-40; Aβ1-42). Amyloid beta peptides are of key importance in the development of Alzheimer’s disease (AD) and are present in CSF. AD affects approximately 1% of the population over the age of 80. The disease is characterized by aggregation of Aβ into oligomers, fibrils and plaques deposition of insoluble and aggregated protein in the brain where its neurotoxic action leads to neuronal cell death. The deposits, also called amyloid plaques, are formed around the neuropil. The exact molecular mechanism is still unclear. Aβ is a proteolytic cleavage product, by APP-cleaving enzyme 1 (BACE1) and β-secretase complex, of membrane bound amyloid precursor protein (APP). Amyloid is the term used for proteins that are misfolded into a cross β-sheet structure. Aβ is produced by various cell types and is secreted in the interstitial fluid. There are multiple cleavage sites in Aβ domain leading to various fragments of 36-43 amino acids in length. The main peptide in the CSF terminate at residue 40. CSF contains many Aβ isoforms, of which Aβ40 is approximately 10 times more abundant than Aβ42. Aβ40 levels are unchanged in AD, but there is a change in Ab40:Aβ42 ratio in AD. This ratio has been thought of diagnostic importance. Assessment of Aβ in brain tissue is essential for diagnosis and is crucial for investigating the molecular mechanisms underlying AD.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155858211,"sku":"HYBHM2325100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0f6c713d-57ac-41c8-8091-733d6de8db4b.png?v=1753031990"},{"product_id":"amyloid-beta-40-human-mab-vu-17-20-ug","title":"Amyloid beta 40, Human, mAb VU-17, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155890979,"sku":"HYBHM232520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6daad738-703d-4264-a529-78382518a404.png?v=1753031993"},{"product_id":"alpha-1-antitrypsin-human-mab-3c11","title":"Alpha-1 antitrypsin, Human, mAb 3C11","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156710179,"sku":"HYBHM2358100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_72cebe9c-0f4c-4061-93a1-4994d6a0d271.png?v=1753032077"},{"product_id":"alpha-1-antitrypsin-human-mab-3c11-1","title":"Alpha-1-antitrypsin, Human, mAb 3C11","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156742947,"sku":"HYBHM235820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3d719a6e-a294-4351-9f2f-94c9e76e9db0.png?v=1753032080"},{"product_id":"alpha-1-antitrypsin-human-mab-3c11-500-ug","title":"Alpha-1-antitrypsin, Human, mAb 3C11, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156775715,"sku":"HYBHM2358500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_7b70461b-d4ef-4c0e-89f0-72a073aa0ddb.png?v=1753032083"}],"url":"https:\/\/chromspec.com\/collections\/14955-antibody-name-a.oembed?page=3","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}