{"title":"14957-Antibody Name B","description":"","products":[{"product_id":"beta1-integrin-human-mab-bv7","title":"Beta1 Integrin, Human, mAb BV7","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody BV7 recognizes human ß1-integrin. Beta-1 integrin is a ubiquitously expressed ~89 kDa type I transmembrane protein functioning as receptor when heterodimerized with one alpha subunit. It belongs to the integrin beta chain family consisting of four different genes, encoding multiple β-integrins via alternative splicing. Ligand-recognition depends on the composition of the heterodimer: either collagen, fibronectin, VCAM1, laminin, cytotactin, osteopontin, epiligrin, thrombospondin and CSPG4 can bind to the integrin-complex. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with α7, β1-integrin regulates cell adhesion and laminin matrix deposition. BV7 is active on HT-29 colon carcinoma cells and on HCCP-2998 tumor cells. It is involved in promoting endothelial cell motility and angiogenesis. Furthermore, β1-integrin plays a mechanistic adhesive role during telophase, and is required for the successful completion of cytokinesis. Upon activation integrins in general, including β1-integrin, are known to exhibit global structural rearrangements and exposure of ligand binding sites. β1-integrin modulation is of importance in tissue repair and regeneration. In cultured primary hippocampal neurons, astrocytes and tissues, cell surface expression of amyloid beta fibrils (key hallmark of Alzheimer’s disease) selectively co-localized with β1-integrin. Preincubation of cells with antibodies against β1-integrin, as well as α1-integrin, greatly enhanced amyloid beta-induced apoptosis, indicating a protective role for integrins in apoptosis. The monoclonal antibody BV7 does not recognize α5β1 complex and not the cytoplasmic part of the β1-subunit. Monoclonal antibody BV7 is active on HT-29 colon carcinoma cells and on HCCP-2998 tumor cells. BV7 binds to several other tumor cells (MG3 osteosarcoma, A375 melanoma, MHCC- 1410 and Lovo colon carcinoma) but does not affect adhesion to endothelial cells.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135181603,"sku":"HYBHM2033100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ad8b46fb-0307-4489-be08-293cf5d6aab2.png?v=1753031213"},{"product_id":"beta1-integrin-human-mab-bv7-20-ug","title":"Beta1 Integrin, Human, mAb BV7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135214371,"sku":"HYBHM203320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c70bd490-86f5-440d-80ec-dea66082e748.png?v=1753031216"},{"product_id":"beta-3-integrin-subunit-human-mab-bv4","title":"Beta-3 integrin subunit, Human, mAb BV4","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody BV4 recognizes human beta3 integrin subunit present in Platelet glycoprotein GPIIb-IIIa (integrin alphaIIb\/beta3, CD41\/CD61) and in the vitronectin receptor (integrin alphaV\/beta3, CD51\/CD61). Intergins are a family of heterodimeric membrane glycoproteins expressed on diverse cell types which function as the major receptors for extracellular matrix and as cell-cell adhesion molecules. As adhesion molecules they play an important role in numerous biological processes such as platelet aggregation, inflammation, immune function, wound healing, tumour metastasis and tissue migration during embryogenesis. In addition integrins are involved in signaling pathways, transmitting signals both into an out from cells. All integrins consist of two non-covalently associated subunits, alpha and beta. At least 12 different alpha subunits and 8 beta subunits have been identified. The beta subunits all contain 56 conserved cysteines (except beta4 which has 48) which are arranged in four repeating units. The beta3 subunit is a 93kDa protein that contains a large loop in the N-terminus stabilized by intrachain disulphide bonding with the first cysteine-rich repeat.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135443747,"sku":"HYBHM2035100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_40a77b95-8140-498f-b1af-756e40d1a2c9.png?v=1753031234"},{"product_id":"beta-3-integrin-subunit-human-mab-bv4-20-ug","title":"Beta-3 integrin subunit, Human, mAb BV4, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135476515,"sku":"HYBHM203520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9543515e-4ab8-4a63-8fdc-e60387bbf85f.png?v=1753031237"},{"product_id":"bpi-human-mab-3f9","title":"BPI, Human, mAb 3F9","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 3F9 reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin. The monoclonal antibody 3F9 recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135804195,"sku":"HYBHM2041100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_72fd7c2c-e608-4471-8bd7-2b1c1358ad38.png?v=1753031269"},{"product_id":"bpi-human-mab-3f9-20-ug","title":"BPI, Human, mAb 3F9, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135869731,"sku":"HYBHM204120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b6713df5-2898-45e8-a8a0-cc467495960e.png?v=1753031272"},{"product_id":"bpi-human-mab-4h5","title":"BPI, Human, mAb 4H5","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 4H5 reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin. The monoclonal antibody 4H5 recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135902499,"sku":"HYBHM2042100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0ad88bd2-db30-4a8d-a1cf-2b6624d819bf.png?v=1753031275"},{"product_id":"bpi-human-mab-4h5-20-ug","title":"BPI, Human, mAb 4H5, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135935267,"sku":"HYBHM204220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_dbdc30a9-4e5e-4f8d-b841-167649ab85d2.png?v=1753031278"},{"product_id":"b-ck-human-mab-ck-byk-21e10","title":"B-CK, Human, mAb CK-BYK\/21E10","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614141374755,"sku":"HYBHM211020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4d46681c-ee28-4b4f-9114-efffbf6bb836.png?v=1753031469"},{"product_id":"beta2-adrenoceptor-human-mab-6h8","title":"Beta2-adrenoceptor, Human, mAb 6H8","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 6H8 recognizes human beta2-adrenoceptor. The b -adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614151074083,"sku":"HYBHM2238100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_36ef68a1-b2a4-412f-8fbd-b73e92646e0d.png?v=1753031833"},{"product_id":"beta2-adrenoceptor-human-mab-6h8-20-ug","title":"Beta2-adrenoceptor, Human, mAb 6H8, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614151106851,"sku":"HYBHM223820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_28dffd29-a9c2-4b07-9a64-92e3ac847ca0.png?v=1753031837"},{"product_id":"basophils-human-mab-2d7","title":"Basophils, Human, mAb 2D7","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 2D7- is a specific marker for basophils detecting- a basophil-specific protein of 7.2-7.5 kDa localized in secretory granules. Activated basophils- have been shown to have a reduced staining with the 2D7 antibody consistent with localization of the antigen- to secretory granules.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153072931,"sku":"HYBHM2279100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ec8b9d4f-c877-42d3-841c-5dca82696d9a.png?v=1753031870"},{"product_id":"basophils-human-mab-2d7-20-ug","title":"Basophils, Human, mAb 2D7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153105699,"sku":"HYBHM227920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_dc13b359-f3a7-4f73-a51a-27cfa6b081d0.png?v=1753031873"},{"product_id":"b-fabp-human-mab-1f5","title":"B-FABP, Human, mAb 1F5","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody clone 1F5 recognizes human brain fatty acid binding protein (B-FABP, FABP7) of both natural and recombinant origin. The B-FABP protein is derived from the human FABP7 gene. FABPs are small intracellular proteins (~13-14 kDa) with a high degree of tissue specificity that bind long chain fatty acids. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of ischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. B-FABP is localized in the brain and other neural tissues.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614154350883,"sku":"HYBHM2299100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_443d9cab-6950-4647-a13c-4889398a8bbf.png?v=1753031980"},{"product_id":"b-fabp-human-mab-1f5-20-ug","title":"B-FABP, Human, mAb 1F5, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614154383651,"sku":"HYBHM229920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e35e343c-90c2-4523-882a-b4f44d3fd0c1.png?v=1753031984"},{"product_id":"b-fabp-human-mab-2d2","title":"B-FABP, Human, mAb 2D2","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody clone-2D2 recognizes human brain fatty acid binding protein (B-FABP, FABP7) of both natural and recombinant origin. The B-FABP protein is derived from the human FABP7 gene. FABPs are small intracellular proteins (~13-14 kDa) with a high degree of tissue specificity that bind long chain fatty acids. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of ischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. B-FABP is localized in the brain and other neural tissues.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614154416419,"sku":"HYBHM2300100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_09802056-7893-4f5c-b6f2-1232c62b54e9.png?v=1753031987"},{"product_id":"b-fabp-human-mab-2d2-20-ug","title":"B-FABP, Human, mAb 2D2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614154449187,"sku":"HYBHM230020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_45cd191c-bb17-4c45-af4e-90f21ed3a714.png?v=1753031990"},{"product_id":"beta-defensin-2-human-clone-hb12g9","title":"Beta-defensin 2, Human, clone HB12G9","description":"\u003cp\u003eMonoclonal antibody HB12G9 recognized human beta defensin-2 (HBD2). hBD-2 is a cysteine-rich cationic 41 amino acid antimicrobial peptide of 4-5 kDa.\u003c\/p\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614160675107,"sku":"HYBHM2390100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_dd9e0c38-13b4-472f-80dd-9496f0320df4.png?v=1753032191"},{"product_id":"beta-defensin-2-human-mab-hb12c9-20-ug","title":"Beta-defensin 2, Human, mAb HB12C9, 20 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614160707875,"sku":"HYBHM239020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d04cefc0-ba7d-4144-8b73-1ed5e752ee0d.png?v=1753032194"},{"product_id":"beta-defensin-2-human-mab-hb2g7-100-ug","title":"Beta-defensin 2, Human, mAb HB2G7, 100 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161068323,"sku":"HYBHM2402100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_01c1f83b-6add-4675-bab3-505a93d8d478.png?v=1753032231"},{"product_id":"beta-defensin-2-human-mab-hb2g7-20-ug","title":"Beta-defensin 2, Human, mAb HB2G7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161101091,"sku":"HYBHM240220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_acb2921a-369b-4135-ba71-a839b5e6d96d.png?v=1753032234"},{"product_id":"beta-defensin-2-human-mab-hb5c10-100-ug","title":"Beta-defensin 2, Human, mAb HB5C10, 100 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161133859,"sku":"HYBHM2403100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3eab89e2-8f38-4eb0-91a1-1ef52bd561c9.png?v=1753032237"},{"product_id":"beta-defensin-2-human-mab-hb5c10-20-ug","title":"Beta-defensin 2, Human, mAb HB5C10, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161166627,"sku":"HYBHM240320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4a2d65af-2e1c-4f82-9313-5a4c391828ad.png?v=1753032241"}],"url":"https:\/\/chromspec.com\/collections\/14957-antibody-name-b.oembed?page=2","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}