{"title":"14963-Antibody Name E","description":"","products":[{"product_id":"elafin-human-mab-trab2o","title":"Elafin, Human, mAb TRAB2O","description":"\u003cul\u003e\n\u003cli\u003eElafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria. TRAB2O recognises all known Trappins via the GQDPVK epitope. TRAB2O shows strong reaction with human native full-length Elafin\/SKALP and a weaker reaction with fully processed Elafin\/SKALP (C-terminal 57 aa). For detection of fully processed Elafin\/SKALP (C-terminal 57 aa) we advise to use HM2063. The antibody is cross reactive with Trappin family members of other species with GQDPVK epitope.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137278755,"sku":"HYBHM2062100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_20c4b43c-eb4a-406a-abd8-c0f2d664ce37.png?v=1753031260"},{"product_id":"elafin-human-mab-trab2o-20-ug","title":"Elafin, Human, mAb TRAB2O, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137311523,"sku":"HYBHM206220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f291fbc9-f11e-47ba-90ec-f31ab73f1b04.png?v=1753031263"},{"product_id":"elafin-human-mab-trab2f","title":"Elafin, Human, mAb TRAB2F","description":"\u003cul\u003e\n\u003cli\u003eElafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria. TRAB2F is an Elafin\/SKALP specific antibody which shows strong reaction with fully processed Elafin\/SKALP (C-terminal 57 aa) and a weaker reaction with human native full-length Elafin\/SKALP. The antibody can be used for purification of human native full-length Elafin\/SKALP. For detection of human native full-length Elafin\/SKALP we advise to use HM2062.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137344291,"sku":"HYBHM2063100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_df3ac7da-1a90-4642-9a61-ff00d3ec269e.png?v=1753031267"},{"product_id":"elafin-human-mab-trab2f-20-ug","title":"Elafin, Human, mAb TRAB2F, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137377059,"sku":"HYBHM206320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b72c8954-34f1-450d-a170-0b1a618349b8.png?v=1753031270"},{"product_id":"epcr-human-mab-rcr-379","title":"EPCR, Human, mAb RCR-379","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody RCR-252 recognizes human endothelial protein C receptor (EPCR), a highly glycosylated type I transmembrane protein of 221-amino-acids. These amino acids comprise an extracellular domain, a 25-aa transmembrane domain, and a short (3 aa) intracytoplasmic sequence coding for an ~46 kDa protein. Deglycosylation will reduce the protein mass to 25 kDa. EPCR is expressed strongly on the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143308067,"sku":"HYBHM2144100UG","price":1086.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9a28a1f1-6a90-48d0-85d4-6160f5245b84.png?v=1753031496"},{"product_id":"epcr-human-mab-rcr-379-20-ug","title":"EPCR, Human, mAb RCR-379, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143340835,"sku":"HYBHM214420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_7d9b687d-47b5-4cfd-bc86-7367ed340ba5.png?v=1753031499"},{"product_id":"epcr-human-mab-rcr-252","title":"EPCR, Human, mAb RCR-252","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody RCR-252 recognizes human endothelial protein C receptor (EPCR), a highly glycosylated type I transmembrane protein of 221-amino-acids. These amino acids comprise an extracellular domain, a 25-aa transmembrane domain, and a short (3 aa) intracytoplasmic sequence coding for an ~46 kDa protein. Deglycosylation will reduce the protein mass to 25 kDa. EPCR is expressed strongly on the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143373603,"sku":"HYBHM2145100UG","price":1086.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_99d9e0c6-5489-4045-8c5e-4dead37f9b87.png?v=1753031503"},{"product_id":"epcr-human-mab-rcr-252-20-ug","title":"EPCR, Human, mAb RCR-252, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143406371,"sku":"HYBHM214520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4ad8ae3d-7449-4e93-b4b6-25a38c0b4371.png?v=1753031506"},{"product_id":"elastase-human-mab-265-3k1","title":"Elastase, Human, mAb 265-3K1","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 265-3K1 recognizes human leukocyte elastase. Leukocyte elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin\/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614145700131,"sku":"HYBHM2174100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b70d7a6a-890a-41d9-b763-ff13622ef200.png?v=1753031704"},{"product_id":"elastase-human-mab-265-3k1-20-ug","title":"Elastase, Human, mAb 265-3K1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614145732899,"sku":"HYBHM217420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ed72b18d-15a4-4634-b0bb-b80aafaecc3a.png?v=1753031708"},{"product_id":"elastase-human-mab-265-3k1-500-ug","title":"Elastase, Human, mAb 265-3K1, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614145765667,"sku":"HYBHM2174500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6abe0b82-79d6-40fa-aae2-c7ac0de404ca.png?v=1753031711"},{"product_id":"e-selectin-human-mab-ena1","title":"E-selectin, Human, mAb ENA1","description":"\u003cul\u003e\n\u003cli\u003eENA1 reacts with E-selectin CD62-E, previous designated the Endothelial Leucocyte Adhesion Molecule-1 (ELAM-1). The antibody reacts with human endothelial cells activated with TNF-alpha, IL-1 or endotoxin. The antibody was found to react also with cells transfected with the E-selectin gene. The antibody inhibits the adhesion of granulocytes both neutrophilic and eosinophilic.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Functional Studies , Immunoassays , Immunoprecipitation\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614165033251,"sku":"HYBHM4001100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_7d31abaf-521f-440e-bbac-3ed0206eee0e.png?v=1753032382"},{"product_id":"e-selectin-human-mab-ena1-20-ug","title":"E-selectin, Human, mAb ENA1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614165066019,"sku":"HYBHM400120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_7bff1647-3166-40e7-b17a-c83cbd3d12f3.png?v=1753032385"},{"product_id":"e-selectin-human-mab-ena1-500-ug","title":"E-selectin, Human, mAb ENA1, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614165098787,"sku":"HYBHM4001500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_69559c16-5093-4332-8366-a337ffb1e9fb.png?v=1753032389"},{"product_id":"e-selectin-human-mab-ena2","title":"E-selectin, Human, mAb ENA2","description":"\u003cul\u003e\n\u003cli\u003eENA2 reacts with E-selectin CD62-E, previous designated the Endothelial Leucocyte Adhesion Molecule-1 (ELAM-1). The antibody reacts with human endothelial cells activated with TNF-alpha, IL-1 or endotoxin. The antibody was found to react also with cells transfected with the E-selectin gene. The antibody inhibits the adhesion of granulocytes both neutrophilic and eosinophilic.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Functional Studies , Immunoassays , Immunofluorescence\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614165131555,"sku":"HYBHM4003100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_bfedc31b-0495-497c-aa81-e5fdbb6a7d82.png?v=1753032392"},{"product_id":"e-selectin-human-mab-ena2-20-ug","title":"E-selectin, Human, mAb ENA2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614165164323,"sku":"HYBHM400320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d11dee34-2d1e-47d1-a975-1a398362d651.png?v=1753032395"}],"url":"https:\/\/chromspec.com\/collections\/14963-antibody-name-e.oembed?page=2","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}