{"title":"14967-Antibody Name G","description":"","products":[{"product_id":"gc1q-r-human-mab-60-11","title":"gC1q-R, Human, mAb 60.11","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133575971,"sku":"HYBHM201420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5de3a1f2-b238-4b36-ae30-c7bbf3e4ff4b.png?v=1753031097"},{"product_id":"gc1q-r-human-mab-74-5-2","title":"gC1q-R, Human, mAb 74.5.2","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133707043,"sku":"HYBHM201520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_21451341-e8b8-49eb-9b21-88e6666df928.png?v=1753031107"},{"product_id":"gc1q-r-human-mab-74-5-2-500-ug","title":"gC1q-R, Human, mAb 74.5.2, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133739811,"sku":"HYBHM2015500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d480ad72-6df5-4aac-9f14-bcebe2ff0820.png?v=1753031110"},{"product_id":"gef-h1-human-mab-b4-7","title":"GEF-H1, Human, mAb B4\/7","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody B4\/7 recognizes human and canine guanine nucleotide exchange factor H1 (GEF-H1). GEFH1 is an ~110 kDa protein belonging to the Dbl family of proto-oncogenes. GEF-H1 can activate the small GTPase RhoA, but not Rac1 or Cdc42. Rho family GTPases are central regulators of epithelial tight junctions and the cytoskeleton. GEF-H1 can associate with different cytoskeletal structures, namely microtubules and the actin cytoskeleton. It has also been proposed to mediate crosstalk between the two types of filaments.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143832355,"sku":"HYBHM2152100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5977e28a-31d9-4c49-98f0-b62fd97ee79c.png?v=1753031543"},{"product_id":"gef-h1-human-mab-b4-7-20-ug","title":"GEF-H1, Human, mAb B4\/7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143865123,"sku":"HYBHM215220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_669c1747-036d-41c4-b11f-23104ce23a8e.png?v=1753031547"},{"product_id":"galectin-3-human-mab-b2c10-100-ug","title":"Galectin-3, Human, mAb B2C10, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody B2C10 reacts with galectin-3, a 30 kDa protein. Galectin-3 is a member of the galectin family. The protein is composed of three domains: a small amino-terminal domain, a carboxyl-terminal carbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. The expression is also affected by neoplastic transformation: up-regulated in certain types of lymphomas and thyroid carcinoma, while down-regulated in other types of malignancies, such as colon, breast, ovarian and uterine carcinomas. Galectin-3 has been shown to function through both intracellular and extracellular actions. Related to its intracellular functions, galectin-3 has been identified as a component of heterogeneous nuclear ribonuclear protein (hnRNP), a factor in pre-mRNA splicing, and has been found to control cell cycle and prevent T cell apoptosis. On the other hand, this protein has also been demonstrated to function as extracellular molecule in activating various types of cells, including monocytes\/macrophages, mast cells, neutrophils and lymphocytes. Galectin-3 has been shown to mediate cell-cell and cell-extracellular matrix interactions. The monoclonal antibody B2C10 inhibits the binding of 125I-labeled galectin-3 to IgE coated on microtiter plates, the galecin-3's hemagglutination activity and galectin-3-induced superoxide production by human neutrophils. This inhibitory activity of B2C10 is probably the result of its disruption of the self-association process. The epitope of the monoclonal antibody B2C10 is found within the first 45 amino acids of galectin-3. The antibody B2C10 does not react with Galecin-3C and is cross reactive with mouse galectin-3.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614145995043,"sku":"HYBHM2186100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_42aaca38-9a8e-44ae-b00b-0cbaccf1026b.png?v=1753031735"},{"product_id":"galectin-3-human-mab-b2c10-10-mg","title":"Galectin-3, Human, mAb B2C10, 10 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148387107,"sku":"HYBHM218610MG","price":14815.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d06e85d5-78de-4134-b234-ee202301687b.png?v=1753031738"},{"product_id":"galectin-3-human-mab-b2c10-1-mg","title":"Galectin-3, Human, mAb B2C10, 1 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148419875,"sku":"HYBHM21861MG","price":2965.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_75deef2c-4939-4132-9ce4-1be6b56ad830.png?v=1753031742"},{"product_id":"galectin-3-human-mab-b2c10","title":"Galectin-3, Human, mAb B2C10","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148452643,"sku":"HYBHM218620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3ad3f15c-4398-49d4-a383-d5298b61bd48.png?v=1753031745"},{"product_id":"galectin-3-human-mab-b2c10-500-ug","title":"Galectin-3, Human, mAb B2C10, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148485411,"sku":"HYBHM2186500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_daeeabbe-f4db-43bd-b4bd-38d5e60c4322.png?v=1753031748"},{"product_id":"galectin-3-human-mab-b2c10-5-mg","title":"Galectin-3, Human, mAb B2C10, 5 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148518179,"sku":"HYBHM21865MG","price":11107.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d4b077bc-dfa1-4806-86ca-30d6c250bd27.png?v=1753031752"},{"product_id":"galectin-8-human-mab-106-1","title":"Galectin-8, Human, mAb 106.1","description":"\u003cul\u003e\n\u003cli\u003eGalectins are animal lectins that can specifically bind beta-galactosides. Thirteen galectins have already been described, belonging to three different groups: prototype, tandem-repeat and chimeric. Galectins are involved in cellular interactions and neoplastic transformations. Galectin-8, is a 34 kDa protein made of tandem-repeat carbohydrate recognition domains (CRDs), joined by a peptide. Structurally, galectin-8 belongs to the tandem-repeat type galectins. The galectin-8 gene ( LGALS8) encodes numerous mRNAs by alternate splicing and the presence of three unusual polyadenylation signals. These mRNAs could encode for six isoforms of galectin-8, of which three belong to the tandem-repeat galectin group (with two carbohydrate binding domains) and the three others to the prototype group (one carbohydrate binding domain). Galectin-8, like other galectins, is a secreted protein. Upon secretion galectin-8 acts as a physiological modulator of cell adhesion. When immobilized, it functions as a matrix protein equipotent to fibronectin in promoting cell adhesion by ligation and clustering of a selective subset of cell surface integrin receptors. Although galectin-8 is a fairly abundant protein, it is not ubiquitously expressed. It shows a micro-clustering pattern reminiscent of that seen with proteins associated with mitochondria, the Golgi or trans-Golgi membranes. Studies of galectin-8 revealed that galectin-8 positively or negatively regulates cell adhesion, depending on the extracellular context. Cell adhesion to galectin-8 triggers integrin-mediated signalling cascades such as Tyr phosphorylation of FAK and paxillin. Galectin-8 is widely expressed in normal tissues (brain, breast, colon, retina, kidney, pancreas, placenta, spleen, testis, uterus, vascular, esophagus and heart) as well as in tumor tissues (brain, breast, colon, germ cells, head and neck, kidney, muscles, ovary, pancreas, thyroid, placenta, prostate, uterus, lung, stomach and esophagus).\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Functional Studies , Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153007395,"sku":"HYBHM2278100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_86b596b7-ed0e-4b66-b68d-dd327e991098.png?v=1753031863"},{"product_id":"galectin-8-human-mab-106-1-20-ug","title":"Galectin-8, Human, mAb 106.1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153040163,"sku":"HYBHM227820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2d6e427a-c833-44de-8d50-f2c8a63d612b.png?v=1753031866"},{"product_id":"gilt-human-mab-map-ip30","title":"GILT, Human, mAb MaP.IP30","description":"\u003cul\u003e\u003cli\u003eAntibodies derived from clone MAP.IP30 recognize human gamma-interferon-inducible lysosomal thiol reductase (GILT). GILT facilitates major histocompatibility complex (MHC) class II-restricted processing through reduction of protein disulfide bonds in the endocytic pathway. GILT can also facilitate the transfer of disulfide-containing antigens into the cytosol, enhancing their cross-presentation by MHC class I.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153335075,"sku":"HYBHM2284100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2e8ca2d0-46c9-4149-8af0-8b5f912cffd5.png?v=1753031897"},{"product_id":"gilt-human-mab-map-ip30-20-ug","title":"GILT, Human, mAb MaP.IP30, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153367843,"sku":"HYBHM228420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_39274533-b9c2-4f1a-8abd-d07eea83668a.png?v=1753031900"},{"product_id":"glyoxalase-1-human-mab-17e6a12-g4-100-ug","title":"Glyoxalase-1, Human, mAb 17E6A12\/G4, 100 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614159692067,"sku":"HYBHM2370100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_011ff4c1-bd4b-4d42-a1e4-652763b8f142.png?v=1753032128"},{"product_id":"glyoxalase-1-human-mab-17e6a12-g4-20-ug","title":"Glyoxalase-1, Human, mAb 17E6A12\/G4, 20 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614159724835,"sku":"HYBHM237020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9d5ab45f-b8b1-4a10-bbdf-86853d0d8a50.png?v=1753032132"}],"url":"https:\/\/chromspec.com\/collections\/14967-antibody-name-g.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}