{"title":"14974-JAM-A","description":"","products":[{"product_id":"jam-a-human-mab-bv16","title":"JAM-A, Human, mAb BV16","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody BV16 recognizes the human junction adhesion molecule (JAM)-A. Together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3), JAM-A belongs to a family of adhesion proteins with a V-C2 immunoglobulin domain organization and their molecular weight is about 30-40 kDa. JAMs are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. JAM-A is expressed by endothelial and epithelial cells, platelets, neutrophils, monocytes, lymphocytes and erythrocytes. Like all other JAMs, JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A also plays an important role in leukocyte transmigration. Leukocyte transmigration can be blocked by antibodies and by soluble JAM-A\/Fc fusion proteins. Homophilic JAM-A interactions between leukocytes and the endothelium but also heterophilic interactions of JAM-A with the beta2-integrin leukocyte function-associated antigen-1 (LFA-1) are considered to actively guide leukocytes during transmigration. Several studies imply a role for JAM-A in the initiation of atherosclerosis since JAM-A is upregulated on early atherosclerotic endothelium. The adhesion of activated platelets on the activated endothelium is mediated by homophilic interactions of JAM-A.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunofluorescence , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614140260643,"sku":"HYBHM2098100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d0d6c606-8793-4e70-9cf1-752c5d39c0d1.png?v=1753031364"},{"product_id":"jam-a-human-mab-bv16-20-ug","title":"JAM-A, Human, mAb BV16, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614140293411,"sku":"HYBHM209820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_67505a1a-c6c1-41b7-8e38-3a84ce3fee58.png?v=1753031367"},{"product_id":"jam-a-human-mab-m-ab-f11","title":"JAM-A, Human, mAb M.Ab.F11","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) or JAM-1. JAM-A is a surface glycoprotein duplex (32 and 35 kDa) belongingto the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interactions. It co-distributes with other tight junction components such as ZO-1, 7H6 antigen, cingulin and occludin. Moreover, JAM-A plays a role in platelet aggregation, secretion, adhesion, spreading.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614140391715,"sku":"HYBHM2099100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0e654e86-447d-44cf-8056-45fa78db0395.png?v=1753031374"},{"product_id":"jam-a-human-mab-m-ab-f11-20-ug","title":"JAM-A, Human, mAb M.Ab.F11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614140424483,"sku":"HYBHM209920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a17771bd-c3c9-487e-8fdb-0c5e13b7929d.png?v=1753031377"},{"product_id":"jam-a-human-mab-m-ab-f11-500-ug","title":"JAM-A, Human, mAb M.Ab.F11, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614140457251,"sku":"HYBHM2099500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_59c011dc-fa1d-420d-9c97-de6a7910ec01.png?v=1753031381"}],"url":"https:\/\/chromspec.com\/collections\/14974-jam-a.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}