{"title":"14977-Antibody Name L","description":"","products":[{"product_id":"lrg-human-mab-2f5-a2","title":"LRG, Human, mAb 2F5.A2","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody recognizes leucine-rich alpha-2-glycoprotein (LRG), a member of the leucine-rich repeat family. LRG is a plasma protein of approximately 50 kDa. LRG consists of 312 amino acids. It has 1 galactosamine and 4 glucosamine oliogosacharides attached and has 2 intrachain disulfide bonds. Leucine comprises 66 of the 312 amino acids, and LRG contains at least eight 24-amino acid leucine-rich repeats. The consensus of these residues, termed leucine-rich repeats (LRR), has been identified as an LRR-containing domain. The primary function of LRRs is to provide versatile structural framework of the formation of protein-protein interactions. LRG is expressed during granulocyte differentiation. Although several family members of the leucine-rich repeat family have been shown to be involved in signal transduction, protein-protein interaction, or cell adhesion and development, a function for LRG remains elusive. LRG has been reported as a biomarker for certain diseases including microbial infections and cancer. LRG can be detected in human neutrophils and progenitor cells, but not in peripheral blood mononuclear cells. The monoclonal antibody 2F5.A2 can be used for immuno purification of human LRG.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133477667,"sku":"HYBHM2013100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4272aa79-f4e7-4df4-ba1c-5b89bc5390b7.png?v=1753031087"},{"product_id":"lrg-human-mab-2f5-a2-20-ug","title":"LRG, Human, mAb 2F5.A2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133510435,"sku":"HYBHM201320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_98749cae-a03f-42bc-9d28-4d6d1fc102d6.png?v=1753031090"},{"product_id":"lbp-human-mab-6g3","title":"LBP, Human, mAb 6G3","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 6G3 reacts highly specific with human natural and recombinant LBP. The antibody cross reacts with LBP of a large series of animal species including: sheep, pig, goat, rabbit, dog, rat, bovine and cynomologous monkey, it does not react with murine and horse LBP. The antibody binds to LBP-LPS complexes whereas it inhibits the interaction of this complex with CD14. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.\u003c\/li\u003e\n\u003cli\u003eApplications: Functional Studies , Immunoassays , Immunoprecipitation\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614135968035,"sku":"HYBHM2043100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e5e6c653-f35e-4786-8604-0d01d268bcc7.png?v=1753031281"},{"product_id":"lbp-human-mab-6g3-20-ug","title":"LBP, Human, mAb 6G3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136000803,"sku":"HYBHM204320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e3d9160a-95e1-4357-af97-138b61738bc0.png?v=1753031285"},{"product_id":"lbp-human-mab-1c7","title":"LBP, Human, mAb 1C7","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 1C7 reacts highly specific with human natural and recombinant LBP. Crossreactions with LBP of other species are not observed. The antibody binds poorly to LBP-LPS complexes: it interacts with the LPS binding site. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000 fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.\u003c\/li\u003e\n\u003cli\u003eApplications: Functional Studies , Immunoassays , Immunoprecipitation\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136033571,"sku":"HYBHM2044100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_55e7242c-317a-4f00-bcad-11dbb7b0b05f.png?v=1753031288"},{"product_id":"lbp-human-mab-1c7-20-ug","title":"LBP, Human, mAb 1C7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136066339,"sku":"HYBHM204420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3f71a524-6078-4aff-9f36-2b998b7bb083.png?v=1753031291"},{"product_id":"lipid-a-free-mab-43-200-ug","title":"Lipid A, free, mAb 43, \u003e200 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136099107,"sku":"HYBHM2046200UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_774498eb-c311-401e-bdb2-51aa10c998e1.png?v=1753031295"},{"product_id":"l-fabp-human-mab-l2b10","title":"L-FABP, Human, mAb L2B10","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody L2B10 recognizes human liver fatty acid binding protein (L-FABP) of both natural and recombinant origin. The L-FABP protein is derived from the human FABP1 gene. FABPs are small intracellular proteins (~13-14 kDa) with a high degree of tissue specificity that bind long chain fatty acids. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of ischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. L-FABP is localized in the liver, kidney and intestinal epithelium. The monoclonal antibody L2B10 is useful to detect ischemic areas of human liver. Furthermore, the antibody can be used for the purification of human L-FABP.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136197411,"sku":"HYBHM2049100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4fbbdef0-cff5-4aec-8b52-e883699c084f.png?v=1753031305"},{"product_id":"l-fabp-human-mab-l2b10-20-ug","title":"L-FABP, Human, mAb L2B10, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136230179,"sku":"HYBHM204920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ef18ba21-5568-442e-aa2b-4c50a21eaa8b.png?v=1753031308"},{"product_id":"l-fabp-human-mab-l2b10-500-ug","title":"L-FABP, Human, mAb L2B10, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136262947,"sku":"HYBHM2049500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5cdccff4-05a0-4c9f-83b4-03deb175758f.png?v=1753031312"},{"product_id":"l-fabp-human-mab-k5a6","title":"L-FABP, Human, mAb K5A6","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody K5A6 recognizes human liver fatty acid binding protein (L-FABP) of both natural and recombinant origin. The L-FABP protein is derived from the human FABP1 gene. FABPs are small intracellular proteins (~13-14 kDa) with a high degree of tissue specificity that bind long chain fatty acids. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of ischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. L-FABP is localized in the liver, kidney and intestinal epithelium. The monoclonal antibody K5A6 is useful to detect ischemic areas of human liver.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136328483,"sku":"HYBHM2051100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_010347a0-002c-482a-a285-2e71d30083b6.png?v=1753031317"},{"product_id":"l-fabp-human-mab-k5a6-20-ug","title":"L-FABP, Human, mAb K5A6, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136361251,"sku":"HYBHM205120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_15b16321-91f5-4667-aa2f-96800ae4dcbc.png?v=1753031189"},{"product_id":"ll-37-cap-18-human-mab-3d11","title":"LL-37\/CAP-18, Human, mAb 3D11","description":"\u003cul\u003e\n\u003cli\u003eCationic antimicrobial peptides, such as cathelicidins play important roles in the defense against infections by eliminating a wide range of pathogens. hCAP-18\/LL-37 is the only cathelicidin identified in humans and it is produced by neutrophils, monocytes, mast cells, and epithelial cells. It is stored in these cells as a propeptide, which can be cleaved extracellularly by enzymes like proteinase 3, resulting in the formation of LL-37 and a cathelin part. LL-37 is an amphipathic a-helical peptide that can affect both planktonic bacteria and those residing in biofilms, viruses such as HIV and fungi, and it can neutralize LPS and lipoteichoic acid (LTA). In addition to its antimicrobial actions, LL-37 participates at the interface of innate and adaptive immunity by modulating cytokine and chemokine production by a range of cell types, chemoattracting various immune effector cells and mesenchymal stem cells, regulating autophagy in conjunction with vitamin D, and stimulating angiogenesis and wound healing. LL-37 does not only kill bacteria, but can also modulate (suppress) neutrophil apoptosis via the activation of FPRL1 and P2X7 in bacterial infections. Suppression of neutrophil apoptosis results in the prolongation of their life span, and may be advantageous for host defense against bacterial invasion. Moreover, it functions as a chemotactic agent for neutrophils, monocytes and T cells. LL-37 is markedly resistant to proteolytic degradation and to a limited extent also cytotoxic towards mammalian cells. The antibody detects both free LL37 (MW 4 kDa)and complete hCAP18 (MW 19 kDa). The monoclonal antibody 3D11 can be used for neutralizing the function of LL-37. The ability of mast cells to kill pneumococci was significant attenuated using the monoclonal antibody 3D11.\u003c\/li\u003e\n\u003cli\u003eApplications: Functional Studies , Immunofluorescence , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138196259,"sku":"HYBHM2070100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2efb4c0c-8256-4969-8955-67266a319f9a.png?v=1753031327"},{"product_id":"ll-37-cap-18-human-mab-3d11-20-ug","title":"LL-37\/CAP-18, Human, mAb 3D11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138229027,"sku":"HYBHM207020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5d667782-dabc-4fe0-b68e-4b7b2ca39bc6.png?v=1753031322"},{"product_id":"ll-37-cap-18-human-mab-3d11-500-ug","title":"LL-37\/CAP-18, Human, mAb 3D11, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138261795,"sku":"HYBHM2070500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_77adc651-f196-4004-b3bf-2fad4aef9de4.png?v=1753031325"},{"product_id":"ll-37-cap-18-human-mab-1-1c12","title":"LL-37\/CAP-18, Human, mAb 1-1C12","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 1-1C12 recognizes free LL-37 as well as its precursor human CAP18 (hCAP18). hCAP18 is a cathelicidin protein of ~18 kDa. It belongs to the cathelicidin family of antimicrobial peptides that are characterized by a conserved N-terminal cathelin domain and a variable C-terminal antimicrobial domain. Cathelicidins are predominantly found in the peroxidase-negative granules of neutrophils. During bacterial infections, the life span of neutrophils is regulated by various pathogen- and host-derived substances. Within the neutrophils, the cathelicidins are synthesized as preproproteins. After removal of the signal peptide,they are stored in granules as inactive proforms. The C-terminal antimicrobial peptides are activated when cleaved from the proforms of the cathelicidins by serine proteases from azurophil granules.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138294563,"sku":"HYBHM2071100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_168fec6a-d985-4d44-84d7-62f0d27b1b09.png?v=1753031328"},{"product_id":"ll-37-cap-18-human-mab-1-1c12-20-ug","title":"LL-37\/CAP-18, Human, mAb 1-1C12, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138327331,"sku":"HYBHM207120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b8828359-c3bf-48ac-897e-2990bae95387.png?v=1753031332"},{"product_id":"lox-1-human-mab-23c11","title":"LOX-1, Human, mAb 23C11","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 23C11 recognizes oxidized low-density lipoprotein receptor-1 (LOX-1). LOX-1 is a single-pass type II membrane protein (~45 kDa) and belongs to the C-type lectin-like protein superfamily. LOX-1 is expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver, brain aortic intima, bone marrow, spinal cord and substantia nigra. It is also expressed on the surface of dendritic cells. This unique scavenger receptor LOX-1 plays important roles in atherogenesis. LOX-1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis, inducing vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. LOX-1 associates with oxLDL inducing the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, LOX-1 acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. LOX-1 is involved in the inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. LOX-1 also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. The LOX-1 gene is a so-called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX-1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF-alpha, TGF-beta, and ANG II in vitro, and several proatherogenic factors in vivo. Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Functional Studies , Immunofluorescence\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614142980387,"sku":"HYBHM2138100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6ff0cb93-e0b4-4d12-9bbb-edc09e1fe1f5.png?v=1753031599"},{"product_id":"lox-1-human-mab-23c11-20-ug","title":"LOX-1, Human, mAb 23C11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143013155,"sku":"HYBHM213820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_65af0a42-fa15-464d-99a4-b9a4ab19fd74.png?v=1753031602"},{"product_id":"lox-1-human-mab-23c11-500-ug","title":"LOX-1, Human, mAb 23C11, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143045923,"sku":"HYBHM2138500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5d0ba045-1756-4e21-9989-6fc030e893c4.png?v=1753031605"},{"product_id":"lox-1-human-mab-23c11-fitc","title":"LOX-1, Human, mAb 23C11, FITC","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 23C11 recognizes oxidized low-density lipoprotein receptor-1 (LOX-1). LOX-1 is a single-pass type II membrane protein (~45 kDa) and belongs to the C-type lectin-like protein superfamily. LOX-1 is expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver, brain aortic intima, bone marrow, spinal cord and substantia nigra. It is also expressed on the surface of dendritic cells. This unique scavenger receptor LOX-1 plays important roles in atherogenesis. LOX-1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis, inducing vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. LOX-1 associates with oxLDL inducing the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, LOX-1 acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. LOX-1 is involved in the inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. LOX-1 also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. The LOX-1 gene is a so-called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX-1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF-alpha, TGF-beta, and ANG II in vitro, and several proatherogenic factors in vivo. Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Functional Studies , Immunofluorescence\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143111459,"sku":"HYBHM2138F100UG","price":1012.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d5174fea-b56a-4854-bbaf-c02f762a6ba1.png?v=1753031610"},{"product_id":"lox-1-human-mab-23c11-fitc-20-ug","title":"LOX-1, Human, mAb 23C11, FITC, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143144227,"sku":"HYBHM2138F20UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d8418ecc-6c90-403f-8d93-430c46793e43.png?v=1753031614"},{"product_id":"lactoferrin-human-mab-265-1k1","title":"Lactoferrin, Human, mAb 265-1K1","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 265-1K1 reacts with human lactoferrin (LF), an 80 kDa glycoprotein. Lactoferrin was first isolated from human milk and plays an important part in the immune system and helps to fight infections. Lactoferrin promotes the health of the gastro-intestinal system by improving the intestinal microbial balance. In addition, LF can be found in epithelia and most body fluids and secretions. Lactoferrin is secreted in plasma by neutrophils. Its plasma concentration also represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover. In inflammation lactoferrin is released from secondary granules of neutrophilic leukocytes into the extracellular medium. Therefore the extracellular lactoferrin concentration can be used as an index for neutrophil activation. Lactoferrin strongly binds to iron and this iron binding property is considered to be an important antimicrobial. Human lactoferrin binds to bacterial products through its highly positively charged N-terminus, it kills various bacteria, most probably by inducing intracellular changes in these bacteria without affecting the membrane permeability. Cleavage by pepsin of lactoferrin leads to the release of lactoferricin H. This 47 amino acid peptide has more antimicrobial activity than its precursor and it can inhibit the classical but not the alternative complement pathway. 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