{"title":"14979-Antibody Name M","description":"","products":[{"product_id":"mcp-1-human-mab-mna1","title":"MCP-1, Human, mAb MNA1","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody MNA.1 (formerly known as 5D3-F7) recognizes human natural and recombinant monocyte chemotactic protein-1 (MCP-1). Monocyte chemotactic protein-1 (MCP-1) is a 11 kDa protein belonging to the CC subgroup of the chemokine superfamily, which stimulate the migration of monocytic cells. In contrast, the CXC chemokines predominantly activate polymorphonuclear leukocytes. The coordinated synthesis and release of MCP-1 plays a central role in both acute and chronic inflammatory processes by controlling the influx of phagocytic cells. Furthermore, their state of activation is in concert with primary inflammatory cytokines, such as IL-1, TNF-a, and IL-6. A selective accumulation of MCP-1 in the cerebrospinal fluid (CSF) of AIDS patients with cytomegalovirus encephalitis, but not with other opportunistic infections or primary lymphomas of the central nervous system , has been described. Furthermore, the chemotactic activity of MCP-1 on monocytic cells has been suggested to play a role in psoriasis, rheumatoid arthritis and atherosclerosis. No cross-reactivity of mAb MNA.1 with other cytokines has been detected.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133215523,"sku":"HYBHM2011100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c7d2593b-7f7c-4533-9119-17ff04edb8f3.png?v=1753031080"},{"product_id":"mcp-1-human-mab-mna1-20-ug","title":"MCP-1, Human, mAb MNA1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133444899,"sku":"HYBHM201120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c627bb12-d8e9-4be8-be71-2071615ce5fd.png?v=1753031083"},{"product_id":"mannose-receptor-human-mab-15-2","title":"Mannose receptor, Human, mAb 15-2","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 15-2 recognizes the mannose receptor (MR), also known as CD206, a member of the vertebrate C-type lectin family. The mannose receptor, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 175 kDa single-pass type I transmembrane receptor consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136721699,"sku":"HYBHM2056100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_16550880-46f4-4564-8fff-b0ef169e748e.png?v=1753031216"},{"product_id":"mannose-receptor-human-mab-15-2-10-mg","title":"Mannose receptor, Human, mAb 15-2, 10 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136754467,"sku":"HYBHM205610MG","price":14815.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_85a45a42-f1c4-43a3-86ba-6f235188da6c.png?v=1753031220"},{"product_id":"mannose-receptor-human-mab-15-2-1-mg","title":"Mannose receptor, Human, mAb 15-2, 1 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136787235,"sku":"HYBHM20561MG","price":2965.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_95a8ca1c-c9ac-4fef-b24d-dd5eae22c6b6.png?v=1753031223"},{"product_id":"mannose-receptor-human-mab-15-2-20-ug","title":"Mannose receptor, Human, mAb 15-2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136820003,"sku":"HYBHM205620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_eb8e3d98-3ab5-4b15-a273-4f1741488e32.png?v=1753031226"},{"product_id":"mannose-receptor-human-mab-15-2-500-ug","title":"Mannose receptor, Human, mAb 15-2, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136885539,"sku":"HYBHM2056500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_235334e9-f629-4ec3-84be-0893907d51c2.png?v=1753031230"},{"product_id":"mannose-receptor-human-mab-15-2-5-mg","title":"Mannose receptor, Human, mAb 15-2, 5 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136918307,"sku":"HYBHM20565MG","price":11107.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_151fb556-86be-49d4-b80b-9340a10053bf.png?v=1753031233"},{"product_id":"mbl-human-mab-3e7","title":"MBL, Human, mAb 3E7","description":"\u003cul\u003e\n\u003cli\u003eMannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r\/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of various vertebrate species.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137114915,"sku":"HYBHM2061100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_71daa4a7-1b2f-4fc1-ba24-9f989be11ea7.png?v=1753031247"},{"product_id":"mbl-human-mab-3e7-20-ug","title":"MBL, Human, mAb 3E7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137147683,"sku":"HYBHM206120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9c939ec6-83f7-4449-836b-1fa3b107f315.png?v=1753031250"},{"product_id":"mbl-human-mab-3e7-500-ug","title":"MBL, Human, mAb 3E7, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137180451,"sku":"HYBHM2061500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_abe21637-9c0c-4bc9-bb2d-d7abdd2936b4.png?v=1753031253"},{"product_id":"masp-1-3-human-mab-1e2","title":"MASP-1\/3, Human, mAb 1E2","description":"\u003cul\u003e\n\u003cli\u003eThree pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASP) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of microorganisms, MASP are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP-1, MASP-2 and MASP-3. MASP-1 appears to cleave the second complement component C2, but not C4. The proteolytic activities of MASP-1 are inhibited by C1-inhibitor. Furthermore MASP-1 has a reactivity profile very similar to that of thrombin. MASP-1 is able to catalyse the formation of cross-linked fibrin. Participation of MASP-1 in cross-linked fibrin clot formation causes release of a chemotactic factor representing a biologically significant activity of MASP-1. The alternative-splicing product from MASP-1 gene is called MASP-3. MASP-1 is associated with smaller MBL oligomers whereas MASP-3 is found on larger oligomers. The substrate of MASP-3 is unknown. The antibody recognizes the heavy chain common to both MASP-1 and MASP-3.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614139703587,"sku":"HYBHM2092100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c5aaf8d9-d541-4912-ba2e-46d6d79aa506.png?v=1753031457"},{"product_id":"masp-1-3-human-mab-1e2-20-ug","title":"MASP-1\/3, Human, mAb 1E2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614139736355,"sku":"HYBHM209220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b76ba204-f879-4e50-b7da-6ed86d005611.png?v=1753031460"},{"product_id":"masp-1-3-human-mab-2b11","title":"MASP-1\/3, Human, mAb 2B11","description":"\u003cul\u003e\n\u003cli\u003eThree pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASP) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of microorganisms, MASP are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP-1, MASP-2 and MASP-3. MASP-1 appears to cleave the second complement component C2, but not C4. The proteolytic activities of MASP-1 are inhibited by C1-inhibitor. Furthermore MASP-1 has a reactivity profile very similar to that of thrombin. MASP-1 is able to catalyse the formation of cross-linked fibrin. Participation of MASP-1 in cross-linked fibrin clot formation causes release of a chemotactic factor representing a biologically significant activity of MASP-1. The alternative-splicing product from MASP-1 gene is called MASP-3. MASP-1 is associated with smaller MBL oligomers whereas MASP-3 is found on larger oligomers. The substrate of MASP-3 is unknown. The antibody recognizes the heavy chain common to both MASP-1 and MASP-3.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614139769123,"sku":"HYBHM2093100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a2bfffb8-3800-4296-ab8b-1e2793003ee4.png?v=1753031464"},{"product_id":"masp-1-3-human-mab-2b11-20-ug","title":"MASP-1\/3, Human, mAb 2B11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614139801891,"sku":"HYBHM209320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ecd240cc-81d8-4433-ba5d-7f9d8fe5f3cc.png?v=1753031467"},{"product_id":"melanoma-associated-antigen-human-mab-nki-m6","title":"Melanoma associated antigen, Human, mAb NKI\/M6","description":"\u003cul\u003e\n\u003cli\u003eMelanoma associated antigen (MAA) is dispersed in the cytoplasma of melanoma cells, and is more concentrated inside vacuoles and sometimes on the melanosomes. Occasionally the antigen is seen on the cell surface. The antigen is actively shed from living cells. Although the antigen is associated with melanomas, it is not codistributed with the tyrosinase activity associated with melagonesis. The antigen shows codistribution with cathepsin D, which is a marker for lysosomal functions. This antibody NKI\/M6 recognizes a high molecular weight proteoglycan with a molecular weight of;450 kD (chondroitin sulfate) and 250 kD (core protein). The antibody NKI\/M6 reacts with melanoma cells derived from cell lines and short term cultures and reacts preferentially with melanoma cells in frozen sections. NKI\/M6 can also be used to detect melanoma lesions in vivo. NKI\/M6 shows cross-reactivity with most naevi and perineurium, and shows weak reactivity with hair follicles.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614142652707,"sku":"HYBHM2129100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c0221bf6-587c-492c-bf5f-8f7ea4d44c11.png?v=1753031565"},{"product_id":"melanoma-associated-antigen-human-mab-nki-m6-20-ug","title":"Melanoma associated antigen, Human, mAb NKI\/M6, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614142685475,"sku":"HYBHM212920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_bc5d2b4c-6fc7-4b69-99eb-18adaf746ee0.png?v=1753031569"},{"product_id":"melanoma-associated-antigen-human-mab-nki-beteb","title":"Melanoma associated antigen, Human, mAb NKI\/beteb","description":"\u003cul\u003e\n\u003cli\u003eMelanoma associated antigen (MAA) is dispersed in the cytoplasma of melanoma cells, and is more concentrated inside vacuoles and sometimes on the melanosomes. Occasionally the antigen is seen on the cell surface. The antigen is actively shed from living cells. Although the antigen is associated with melanomas, it is not codistributed with the tyrosinase activity associated with melagonesis. The antigen shows codistribution with cathepsin D, which is a marker for lysosomal functions. The antibody NKI\/beteb recognizes a (pre)melanosomal 100 kD and 7 kD antigen (glycoprotein). The antibody reacts with melanomas, clear cells sarcomas (melanoma of soft tissue), nevocellular nevi, and normal melanocytes. Except for one case of non-Hodgkin's lymphoma in which macrophages were positive, no reactions with other tumors or tissues have been observed.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunofluorescence , Paraffin Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614142718243,"sku":"HYBHM2130100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c321251e-68df-4acf-96bd-17e92a3792b6.png?v=1753031572"},{"product_id":"melanoma-associated-antigen-human-mab-nki-beteb-20-ug","title":"Melanoma associated antigen, Human, mAb NKI\/beteb, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614142751011,"sku":"HYBHM213020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a32ca0cb-3077-4a36-bde8-2c57dca5665d.png?v=1753031575"},{"product_id":"macrophages-mature-human-mab-25f9","title":"Macrophages mature, Human, mAb 25F9","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 25F9 recognises a protein of 86 kD on the cell surface and within the cytoplasm of mature macrophages. The antibody is associated with fully differentiated tissue macrophages both in normal and in diseased tissues, independently of the presence or absence of inflammation. The antigen is absent on freshly isolated monocytes and other blood cells. After 6 to 7 days culture human monocytes become positive. Some melanoma and carcinoma cell lines are also positive. Furthermore the monoclonal antibody 25F9 cross reacts with a subpopulation of macrophages of rhesus monkey, pig alveolar macrophages and Kupffer cells. The monoclonal antibody 25F9 is very useful for macrophage phenotyping.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144389411,"sku":"HYBHM2158100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_34daff1a-fd65-426f-b9d7-d6c2087674be.png?v=1753031584"},{"product_id":"macrophages-mature-human-mab-25f9-20-ug","title":"Macrophages mature, Human, mAb 25F9, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144422179,"sku":"HYBHM215820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2fa33423-f0d9-4379-bc38-4c5d4f8eede5.png?v=1753031588"},{"product_id":"mpo-human-mab-266-6k1","title":"MPO, Human, mAb 266-6K1","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 266-6K1 recognizes human myeloperoxidase (MPO), an ~135 glycoproteinexpressed in all cells of the myeloid linage. MPO functions as an α2β2 heteromultimer consisting oftwo heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present inazurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used duringphagocytic lysis of engulfed foreign particles which takes part in the defense of the organism throughproduction of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxicintermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO canbe rapidly released and as such useful in body fluids as marker for inflammatory status.Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer,Alzheimer's disease, inflammatory bowel disease and multiple sclerosis. Autoimmune antibodies toMPO (so called ANCA) are involved in Wegener’s disease. Since the discovery of MPO deficiency,initially regarded as rare and restricted to patients suffering from severe infections, MPO has attractedmore clinical attention.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144749859,"sku":"HYBHM2164100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b08cba9f-2806-4cff-9579-a515d07e7d95.png?v=1753031616"},{"product_id":"mpo-human-mab-266-6k1-20-ug","title":"MPO, Human, mAb 266-6K1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144782627,"sku":"HYBHM216420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_55a8043c-7078-4dfe-afdb-3d859dafffe2.png?v=1753031619"},{"product_id":"mpo-human-mab-266-6k1-500-ug","title":"MPO, Human, mAb 266-6K1, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614144815395,"sku":"HYBHM2164500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_87a659cd-3a94-42d6-bdf4-2c498a3a97b6.png?v=1753031623"},{"product_id":"masp-2-human-mab-8b5","title":"MASP-2, Human, mAb 8B5","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 8B5 reacts with the CCP1\/2-SP fragment of human MASP-2. MASP-2 is a trypsin-like serine protease and plays an important rol in the initiation of the MBL complement activation pathway. Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASPs) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of micro organisms, MASPs are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP-1, MASP-2 and MASP-3. Mannan-binding lectin (MBL) and ficolins, in complex with MBL-associated serin proteases (MASPs), are capable of activation the complement system, thus mediating the destruction of infectious agents. MASP-2 cleaves C4 and C2 and is crucial for the activation of downstream complement components.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148616483,"sku":"HYBHM2190100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f6f603cc-ec6f-4255-97e8-3ae829e69bc2.png?v=1753031762"},{"product_id":"masp-2-human-mab-8b5-20-ug","title":"MASP-2, Human, mAb 8B5, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148649251,"sku":"HYBHM219020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b3230ac0-2cdc-4eb9-b920-01adf95c2744.png?v=1753031765"},{"product_id":"masp-2-human-mab-8b5-500-ug","title":"MASP-2, Human, mAb 8B5, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148682019,"sku":"HYBHM2190500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_748717bc-d1b0-4ed3-b25e-9edd60a2c12c.png?v=1753031768"},{"product_id":"masp-2-map19-human-mab-6g12","title":"MASP-2\/MAp19, Human, mAb 6G12","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 6G12 reacts with human MASP-2 and human MAp19. MASP-2 is a trypsin-like serine protease and plays an important rol in the initiation of the MBL complement activation pathway. Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASPs) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of micro organisms, MASPs are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP-1, MASP-2 and MASP-3. Mannan-binding lectin (MBL) and ficolins, in complex with MBL-associated serin proteases (MASPs), are capable of activation the complement system, thus mediating the destruction of infectious agents. MASP-2 cleaves C4 and C2 and is crucial for the activation of downstream complement components. MAp19 is an alternative splicing product of the MASP-2 gene. MAp19 comprises the first two domains of MASP-2 followed by an extra sequence of four unique amino acids (EQSL) at its C-terminal. MASP-2 and MAp19 have been reported to bind to MBL in a calcium-dependent manner. The monoclonal antibody 6G12 reacts with high affinity to the N-terminal end of MASP-2 and Map19.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148714787,"sku":"HYBHM2191100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2b5acaa0-59a8-4c01-88c1-d2089f77402b.png?v=1753031771"},{"product_id":"masp-2-map19-human-mab-6g12-20-ug","title":"MASP-2\/MAp19, Human, mAb 6G12, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148747555,"sku":"HYBHM219120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d13e5804-8936-4061-b3c3-64e1eb19607c.png?v=1753031775"},{"product_id":"masp-2-map19-human-mab-6g12-500-ug","title":"MASP-2\/MAp19, Human, mAb 6G12, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148780323,"sku":"HYBHM2191500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a56443c8-5b6f-4fcc-bff1-4823c689b808.png?v=1753031778"},{"product_id":"madcam-1-human-mab-314g8","title":"MAdCAM-1, Human, mAb 314G8","description":"\u003cul\u003e\n\u003cli\u003eThe monocolonal antibody 314G8 reacts with human mucosal addressin cell adhesion molecules-1 (MAdCAM-1), a key player in mediating the infiltration of leukocytes into chronically inflamed tissue. MAdCAM-1 is a cell-surface Ig superfamily member composed of two extracellular Ig domains, followed by a mucin-like domain, a transmembrane domain and a short cytoplasmatic domain. It interacts via its N-terminal Ig domain with the lymphocyte homing receptor alpha4beta7, which plays a critical role in forming the gut-associated lymphoid system. MAdCAM-1 promotes the adhesion of T- and B cells, monocytes\/macrophages, and potentially eosinophils, basophils, and differentiated mast cells to the vascular endothelium. Mucosal addressin cell adhesion molecule-1 RNA transcripts are predominantly expressed in the small intestine, mesenteric lymph nodes, colon and spleen; and are very weakly expresssed in human pancreas and brain. The monocolonal antibody 314G8 recognizes a site in the N-terminal Ig domain of MAdCAM-1. The monoclonal antibody 314G8 detects MAdCAM-1 on venules in the spleen and small intestine. MAdCAM-1 is strongly expressed in the synovium of osteoarthritis patients, predominantly on the endothelial lining of blood vessels, but also within the vessel lumen. The monoclonal antibody 314G8 may be useful in diagnosis of inflammation in humans by monitoring the presence and levels of MAdCAM-1.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149304611,"sku":"HYBHM2207100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3432edb7-a473-462b-8a14-629ad6520c12.png?v=1753031665"},{"product_id":"madcam-1-human-mab-314g8-20-ug","title":"MAdCAM-1, Human, mAb 314G8, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149337379,"sku":"HYBHM220720UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ab514b3d-9ae8-49e5-b84d-95391cdfc9db.png?v=1753031668"},{"product_id":"madcam-1-human-mab-314g8-fitc","title":"MAdCAM-1, Human, mAb 314G8, FITC","description":"\u003cul\u003e\n\u003cli\u003eThe monocolonal antibody 314G8 reacts with human mucosal addressin cell adhesion molecules-1 (MAdCAM-1), a key player in mediating the infiltration of leukocytes into chronically inflamed tissue. MAdCAM-1 is a cell-surface Ig superfamily member composed of two extracellular Ig domains, followed by a mucin-like domain, a transmembrane domain and a short cytoplasmatic domain. It interacts via its N-terminal Ig domain with the lymphocyte homing receptor alpha4beta7, which plays a critical role in forming the gut-associated lymphoid system. MAdCAM-1 promotes the adhesion of T- and B cells, monocytes\/macrophages, and potentially eosinophils, basophils, and differentiated mast cells to the vascular endothelium. Mucosal addressin cell adhesion molecule-1 RNA transcripts are predominantly expressed in the small intestine, mesenteric lymph nodes, colon and spleen; and are very weakly expresssed in human pancreas and brain. The monocolonal antibody 314G8 recognizes a site in the N-terminal Ig domain of MAdCAM-1. The monoclonal antibody 314G8 detects MAdCAM-1 on venules in the spleen and small intestine. MAdCAM-1 is strongly expressed in the synovium of osteoarthritis patients, predominantly on the endothelial lining of blood vessels, but also within the vessel lumen. The monoclonal antibody 314G8 may be useful in diagnosis of inflammation in humans by monitoring the presence and levels of MAdCAM-1.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149370147,"sku":"HYBHM2207F100UG","price":1012.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2b5ef19a-067d-4a69-8a10-53326c4ff601.png?v=1753031671"},{"product_id":"madcam-1-human-mab-314g8-fitc-20-ug","title":"MAdCAM-1, Human, mAb 314G8, FITC, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149435683,"sku":"HYBHM2207F20UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0b589d2e-5522-4016-b846-0c70b36549c3.png?v=1753031675"},{"product_id":"marco-human-mab-plk-1","title":"MARCO, Human, mAb PLK-1","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody PLK-1 recognizes the macrophage receptor with collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens. The monoclonal antibody PLK-1 binds specifically to MARCO, and has been shown to partially block ligand binding.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunofluorescence , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149501219,"sku":"HYBHM2208100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2e03a467-39db-4f3b-abd6-efd0266fcc22.png?v=1753031678"},{"product_id":"marco-human-mab-plk-1-10-mg","title":"MARCO, Human, mAb PLK-1, 10 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149533987,"sku":"HYBHM220810MG","price":14815.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_af89bb83-a8e4-41f4-bf10-a3546f994353.png?v=1753031682"},{"product_id":"marco-human-mab-plk-1-1-mg","title":"MARCO, Human, mAb PLK-1, 1 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149566755,"sku":"HYBHM22081MG","price":2965.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_22f65eab-7b69-433e-9bcd-6766c233d8b2.png?v=1753031685"},{"product_id":"marco-human-mab-plk-1-20-ug","title":"MARCO, Human, mAb PLK-1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149599523,"sku":"HYBHM220820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9eb01af8-270a-4867-b006-96544a28429a.png?v=1753031688"},{"product_id":"marco-human-mab-plk-1-500-ug","title":"MARCO, Human, mAb PLK-1, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149632291,"sku":"HYBHM2208500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_01c3acd5-0f51-4f4d-86a0-bc8206a1cc6b.png?v=1753031692"},{"product_id":"marco-human-mab-plk-1-5-mg","title":"MARCO, Human, mAb PLK-1, 5 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149665059,"sku":"HYBHM22085MG","price":11107.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b38710d8-99b8-485e-8793-0cdf3ac64d0e.png?v=1753031695"},{"product_id":"masp-3-human-mab-38-12-3","title":"MASP-3, Human, mAb 38:12-3","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 38:12-3 recognizes MASP-3, a 94 kDa mannan-binding lectin (MBL)-associated serine protease. Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component, C3. In the lectin pathway, mannose- binding-lectin (MBL)-associated serine proteases (MASP) form complexes with oligopolymeric lectin molecules, which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of micro-organisms, MASPs are converted to their active forms and initiate complement activation. Six members of the family of MASP-like serine proteases have been reported: MASP-1, MASP-2, MASP-3, Map19, C1r and C1s. These products show identical domain organization, even though the overall amino acid sequence identity is only approximately 40%. Each MASP-type forms homodimers and is individually associated with MBL and the ficolins in a Ca2+-dependent matter. The four MBL-associated proteins are generated from only two genes, the MASP-1\/3 gene encodes MASP-1 and MASP-3, whereas the MASP-2\/Map19 gene gives rise to MASP-2 and the non-enzymatic MASP-2 MAp19. MASP-1 associates preferentially with low oligomer MBL (termed MBL-I), whereas MASP-2 and MASP-3 associate mainly with larger MBL oligomers (MBL II and MBL III). MASP-3 is generated by alternative splicing of the MASP-1\/3 gene. The MASP-3 transcription product is composed of an A chain, which is common to both MASP-1 and MASP-3, and a B chain, which is unique to MASP-3. The biological function of MASP-3 remains unclear. However, MASP-3 was found to downregulate the C4 and C2 cleaving activity of MASP-2. MASP-3 inhibits MASP-2 by a combination of competitive inhibition of MASP-2 association with MBL and inhibition of activation of the MBL-associated MASP-2. The monoclonal antibody 38:12-3 does not recognize MASP-1.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150156579,"sku":"HYBHM2216100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1da2e60c-f63d-48df-9a4b-fa9af41f185e.png?v=1753031746"},{"product_id":"masp-3-human-mab-38-12-3-20-ug","title":"MASP-3, Human, mAb 38:12-3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150189347,"sku":"HYBHM221620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b2cdef06-d5b8-4d0c-aa56-e347f2042724.png?v=1753031749"},{"product_id":"muscarinic-acetylcholine-receptor-m2-human-mab-b8e5","title":"Muscarinic acetylcholine receptor M2, Human, mAb B8E5","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody B8E5 recognizes human muscarinic acetylcholine receptor M2 (M2 receptor), a G protein-coupled cardiovascular receptor of ~55 kDa. This receptor is an integral membrane protein consisting of seven membrane spanning a-helices linked together by extra- and intracellular loops that form a pharmacophore pocket. Autoantibodies directed against cardiovascular G protein-coupled receptors functionally interfering with the target have been described in several cardiovascular diseases. The M2 receptor is the predominant sybtype of muscarinic receptors present in the heart of mammalian species. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Monoclonal antibody B8E5 inhibits the 223-adrenergic L-type Ca2+ currents through activation of the muscarinic acetylcholine receptor M2. It suggests that the antibody acts not via the classical pathway of decreasing cAMP, but rather by increasing cGMP. Monoclonal antibody B8E5 acts by functional dimerization of the receptor resulting in stabilization of the constitutive active receptor dimers and paradoxically induces a small decrease in carbachol affinity for the M2 receptor. It recognizes the pentapeptide VRTVE (aa 168-172) corresponding to the N-terminal part of the second extracellular loop of the human M2 receptor.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Functional Studies , Immunoassays , Immunofluorescence , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614151139619,"sku":"HYBHM2239100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_309b1aa7-8f90-411c-bcf4-5204ce4cce5e.png?v=1753031840"},{"product_id":"musc-acetylcholine-rec-m2-human-mab-b8e5","title":"Musc. acetylcholine rec. M2, Human, mAb B8E5","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614151172387,"sku":"HYBHM223920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_527914ae-9ce8-4d71-b103-a37bcdb83bd1.png?v=1753031843"},{"product_id":"md-2-human-mab-18h10","title":"MD-2, Human, mAb 18H10","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 18H10 reacts with MD-2, an accessory molecule of the Toll-like receptor 4 (TLR4, CD284). TLRs belong to a family of proteins that specifically recognizes and senses microbial products. They are highly conserved throughout evolution and act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. MD-2 exists as a cell surface protein in association with TLR4. It also exists as secreted forms consisting of MD-2 monomers and multimers (sMD-2). Circulating sMD-2 is mainly present as a doublet of ~20 and 25 kD, representing differentially glycosylated forms. Unlike TLR4, sMD-2 binds directly LPS without the need of soluble CD14 (sCD14). However, LPS-MD-2 interactions are increased when LPS is pretreated with CD14. Only monomeric sMD-2 is biologically active and able to associate with TLR4 and LPS. sMD-2 circulates in plasma of healthy individuals as a non-active, polymeric protein. In septic plasma, the total amount of sMD-2 was strongly elevated and contained both sMD-2 polymers and monomers. Soluble MD-2 is proposed to be an important mediator of organ inflammation during sepsis. During experimental human endotoxemia, the monomeric and total sMD-2 content in plasma increased with the kinetics of an acute phase protein. This parallels enhanced TLR4 costimulatory activity. In vitro studies revealed that sMD-2 release appears to be restricted to endothelial and dendritic cells. The monoclonal antibody 18H10 reacts with MD-2. However, it does not react with sMD-2. In addition, the monoclonal antibody 18H10 is able to inhibit bacterial binding to MD-2.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Functional Studies\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614151565603,"sku":"HYBHM2245100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_412d700f-cf59-451a-b1af-3b40a3ec7472.png?v=1753031878"},{"product_id":"md-2-human-mab-18h10-20-ug","title":"MD-2, Human, mAb 18H10, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614151598371,"sku":"HYBHM224520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_840028b2-491b-45c5-b5b4-dcafba6e9277.png?v=1753031881"},{"product_id":"mpo-human-mab-b7","title":"MPO, Human, mAb B7","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody B7 recognizes human myeloperoxidase (MPO), an ~135 glycoproteinexpressed in all cells of the myeloid linage. MPO functions as an α2β2 heteromultimer consisting oftwo heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present inazurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used duringphagocytic lysis of engulfed foreign particles which takes part in the defense of the organism throughproduction of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxicintermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO canbe rapidly released and as such useful in body fluids as marker for inflammatory status.Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer,Alzheimer's disease, inflammatory bowel disease and multiple sclerosis. Autoimmune antibodies toMPO (so called ANCA) are involved in Wegener’s disease. Since the discovery of MPO deficiency,initially regarded as rare and restricted to patients suffering from severe infections, MPO has attractedmore clinical attention. \u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153859363,"sku":"HYBHM2288100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_bb84e913-beb9-4982-9cbe-1ef5df321e7c.png?v=1753031952"},{"product_id":"mpo-human-mab-b7-20-ug","title":"MPO, Human, mAb B7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153892131,"sku":"HYBHM228820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9f45e181-34fa-412d-8e90-33149845105b.png?v=1753031955"},{"product_id":"map44-human-mab-2d5b6","title":"MAP44, Human, mAb 2D5B6","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 2D5B6 reacts specifically with human MAp-44, a protein of approximately 44kDa, which is encoded by an alternatively spliced mRNA of the MASP-1 gene. Up to now 5 MASP proteins have been identified (MASP-1, MASP-2, MASP-3, MAp19 and MAp44) which are encoded by 2 genes. The MASP-2 gene gives rise to MASP2 and MAp19 due to alternative splicing, whereas the MASP-1 gene encodes a primary transcript which can be spliced to three different mRNAs coding for MASP-1, MASP-3 and MAp44. On the protein level MASP-1 and MASP-2 are shown to be responsible for complement activation through proteolytic cleavage of C2 and C4, whereas MASP-3 has been suggested to inhibit the generation of the C3 convertase. So far the role of MAp44 remains elusive. However, recent research have shown that patients suffering from colorectal cancer have increased levels of MAp44 upon surgery as compared to Map44 levels in normal sera. The monoclonal antibody 2D5B6 is suitable for immunohistochemistry, western blotting as well as use in immunoassays. \u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Immunoprecipitation , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614154154275,"sku":"HYBHM2296100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ea55b158-adce-4d81-869e-4cc2d319cd4b.png?v=1753031960"},{"product_id":"map44-human-mab-2d5b6-20-ug","title":"MAp44, Human, mAb 2D5B6, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614154187043,"sku":"HYBHM229620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_fc512bf6-8f45-4756-ad6e-aa54c99a76d5.png?v=1753031964"}],"url":"https:\/\/chromspec.com\/collections\/14979-antibody-name-m.oembed?page=4","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}