{"title":"14992-TNF-RI","description":"","products":[{"product_id":"tnf-ri-human-mab-mr1-2","title":"TNF-RI, Human, mAb MR1-2","description":"\u003cul\u003e\n\u003cli\u003eThe antibody MR1-2 reacts with the extra-cellular part of the TNF-RI. It also reacts with the soluble receptor. TNF-RI is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha: Induction of cytotoxicity and other functions are mediated largely via TNF-RI. The antibody cross reacts with rhesus and cynomolgus natural TNF-RI.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614132461859,"sku":"HYBHM2005100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a5a29b49-fec7-495b-856f-e462c577d069.png?v=1753031137"},{"product_id":"tnf-ri-human-mab-mr1-2-10-mg","title":"TNF-RI, Human, mAb MR1-2, 10 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614132494627,"sku":"HYBHM200510MG","price":14815.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_333b3818-8f73-4bcf-9528-11216acef723.png?v=1753031140"},{"product_id":"tnf-ri-human-mab-mr1-2-1-mg","title":"TNF-RI, Human, mAb MR1-2, 1 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614132527395,"sku":"HYBHM20051MG","price":2965.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6442b719-ce97-4ceb-a40b-194ce360b2ef.png?v=1753031144"},{"product_id":"tnf-ri-human-mab-mr1-2-20-ug","title":"TNF-RI, Human, mAb MR1-2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614132560163,"sku":"HYBHM200520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9b93b2a9-f0a1-4859-b388-1afa0daf91e7.png?v=1753031147"},{"product_id":"tnf-ri-human-mab-mr1-2-500-ug","title":"TNF-RI, Human, mAb MR1-2, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614132592931,"sku":"HYBHM2005500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4866f576-dfde-4583-bc59-ea7061090f56.png?v=1753031151"},{"product_id":"tnf-ri-human-mab-mr1-2-5-mg","title":"TNF-RI, Human, mAb MR1-2, 5 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614132625699,"sku":"HYBHM20055MG","price":11107.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_de4a9861-fb17-4d3e-9c61-c71f0c259b67.png?v=1753031154"},{"product_id":"tnf-ri-human-mab-h398","title":"TNF-RI, Human, mAb H398","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody H398 recognizes the extracellular part of the Tumor Necrosis Factor Receptor type I (TNF-RI) of the membrane-bound as well as the soluble receptor. TNF-RI (~55-60 kDa) is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha. TNF-alpha activates inflammatory responses, induces apoptosis, regulates cellular proliferation, and may even promote cancer progression. The effects of TNF-alpha are mediated by TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. Induction of cytotoxicity and other functions are mediated largely via TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is efficiently activated only by the membrane bound form of TNF-alpha. TNF-RI signaling is initiated when trimeric TNF-alpha binds TNF-RI receptors. Subsequent TNF-RI trimerization promotes the recruitment of a proximal signaling complex composed of TNF Receptor Associated protein with a Death Domain (TRADD), Receptor Interacting Protein (RIP), cellular Inhibitor of Apoptosis Protein 1 (cIAP1), TNF Receptor Associated Factor 2 (TRAF2), and likely TRAF5. Studies with TNF-RI-deficient mice indicate that TNF-RI mediates most of the proliferation, pro-inflammatory, and apoptosis-activating pathways.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614134034723,"sku":"HYBHM2020100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ebe905f4-732d-459a-b1c3-afaeff2d56c0.png?v=1753031138"},{"product_id":"tnf-ri-human-mab-h398-20-ug","title":"TNF-RI, Human, mAb H398, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614134067491,"sku":"HYBHM202020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6b23ddd8-5001-4c8e-b993-adcd74652ae0.png?v=1753031141"},{"product_id":"tnf-ri-human-mab-h398-500-ug","title":"TNF-RI, Human, mAb H398, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614134100259,"sku":"HYBHM2020500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4a8c165a-e2eb-4fb4-b5fb-a2dd26105390.png?v=1753031144"}],"url":"https:\/\/chromspec.com\/collections\/14992-tnf-ri.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}