{"title":"15020-BPI","description":"","products":[{"product_id":"bpi-human-pab-100-ug","title":"BPI, Human, pAb, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eThe polyclonal antibody reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin. The polyclonal antibody recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Immunoprecipitation\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614169686307,"sku":"HYBHP9022100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_943755c6-25f4-4c22-958a-4c411731c507.png?v=1753032538"},{"product_id":"bpi-human-pab","title":"BPI, Human, pAb","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614169719075,"sku":"HYBHP902220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0601ad1f-951b-4be6-a124-5ddd9919e61e.png?v=1753032542"}],"url":"https:\/\/chromspec.com\/collections\/15020-bpi.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}