{"title":"15021-C5L2","description":"","products":[{"product_id":"c5l2-human-pab-100-ug","title":"C5L2, Human, pAb, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eThe orphan receptor C5L2\/pgpr77, which shares 35% amino identity with CD88, is a promiscuous complement fragment-binding protein. C5L2 binds C5a with high affinity but has a 10-fold higher affinity for C5adR than CD88. C5L2 also has an affinity for C4a and C3a, and their metabolites C4a des-Arg, and C3a des-Arg. C3a binds at a site distinct from the C5a binding site. C5L2 transfected into cells does not support degranulation or increases in intracellular [Ca2+] and is not rapidly internalized in response to ligand binding. However, ligation of C5L2 by anaphylatoxin potentiates the degranulation response to cross-linkage of the high affinity IgE receptor suggesting that C5L2 is an anaphylatoxin-binding protein with unique ligand binding and signalling properties. C5L2 is proposed to mediate the acylation-stimulating properties of C3a des-Arg\/ASP. C5L2 is expressed in granulocytes, in mature dendritic cells, adipose tissue and fibroblasts.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunofluorescence , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614170472739,"sku":"HYBHP9036100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d49dda41-9406-41e0-9af5-702ba4e2cbf7.png?v=1753032616"},{"product_id":"c5l2-human-pab","title":"C5L2, Human, pAb","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614170505507,"sku":"HYBHP903620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_265d0191-4506-49a2-a635-19c6b90b8578.png?v=1753032619"}],"url":"https:\/\/chromspec.com\/collections\/15021-c5l2.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}