{"title":"15046-Pro SP-C","description":"","products":[{"product_id":"pro-sp-c-human-pab-100-ug","title":"Pro SP-C, Human, pAb, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eThe polyclonal antibody recognizes the human surfactant protein C (SP-C). There are four surfactant-specific proteins, designated surfactant protein A (SP-A), SP-B, SP-C and SP-D respectively. SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family. SP-B and SP-C are hydrophobic surfactant proteins and may be the most appropriate indicators for the evolutionary origin of surfactant. SP-C is a 34-35 amino acid peptide, of 4 kD that is proteolytically processed from a 21 kD precursor protein. SP-C is initiated early in the embryogenic period of lung formation, where SP-C transcripts are detected uniformly in epithelial cells lining the primitive airways. During lung development SP-C expression is decreased in cells of the proximal conducting portion of the lung. Ultimately SP-C is expressed selectively in type II epithelial cells in the alveolus of the lung. SP-C is secreted into the airspace where it enhances the spreading and stability of surfactant phospholipids in the alveolus. SP-C plays an important role in the spreading and stabilization of phospholipid films in the alveolus. SP-C is essential for air-breathing in mammals and is therefore largely conserved. Deficiency of SP-C and other surfactant components is associated with respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS). The polyclonal antibody is raised against recombinant human pro-SP-C (AA 1-33), GST fusion. The polyclonal antibody is cross reactive with mouse SP-C.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614171226403,"sku":"HYBHP9050100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b23b9edf-fdd7-44f0-9fbc-6144e3ddd791.png?v=1753032666"},{"product_id":"pro-sp-c-human-pab","title":"Pro SP-C, Human, pAb","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614171259171,"sku":"HYBHP905020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a419d941-3e62-45d9-8d0e-ad2ce669650b.png?v=1753032670"}],"url":"https:\/\/chromspec.com\/collections\/15046-pro-sp-c.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}