{"title":"15049-SP-B","description":"","products":[{"product_id":"sp-b-human-pab-100-ug","title":"SP-B, Human, pAb, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eThe polyclonal antibody recognizes the human surfactant protein B (SP-B). There are four surfactant-specific proteins, designated surfactant protein A (SP-A), SP-B, SP-C and SP-D respectively. SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family. SP-B and SP-C are hydrophobic surfactant proteins and may be the most appropriate indicators for the evolutionary origin of surfactant. SP-B is synthesized by the alveolar type II epithelial cells as a 40-42 kD precursor that is subsequently proteolytically processed to 7.8-8 kD. SP-B enhances the spreading and stability of surfactant phospholipids in the alveolus. SP-B is essential for air-breathing in mammals and is therefore largely conserved. SP-B can interact with both phospholipid head groups and fatty chains and is particularly active in enhancing surface active behaviour in endogenous and exogenous lung surfactants. Even low SP-B contents had measurable effects in increasing the adsorption, dynamic surface tension lowering, and\/or film respreading of DPPC, mixed synthetic lipids, and column-purified lung surfactant phospholipids. Deficiency of SP-B and other surfactant components is associated with respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS). The polyclonal antibody is raised against human-based 60-amino acid synthetic SP-B polypeptide. The antibody recognizes proteins of 42, 25 and 18 kD under nonreducing conditions. The 18 kD form is reduced to 7.7-8 kD in the presence of beta-mercaptoethanol. The polyclonal antibody is cross reactive with mouse, bovine and pig SP-B.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614171128099,"sku":"HYBHP9049100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_02ba6bd8-c4b7-4e17-adaf-021082dd21a5.png?v=1753032660"},{"product_id":"sp-b-human-pab","title":"SP-B, Human, pAb","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614171160867,"sku":"HYBHP904920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_7e0d0865-6566-4ec0-88c0-b260d068b9f3.png?v=1753032663"}],"url":"https:\/\/chromspec.com\/collections\/15049-sp-b.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}