{"title":"15090-TNF-alpha","description":"","products":[{"product_id":"tnf-alpha-human-mab-4h31","title":"TNF-alpha, Human, mAb 4H31","description":"\u003cul\u003e\n\u003cli\u003eThe antibody reacts with human native and recombinant TNF-alpha as assessed by ELISA. The antibody inhibits the biological activity of human native and recombinant TNF-alpha as determined with L929 cells in a cytotoxicity assay. The antibody cross reacts with rhesus and cynomolgus natural TNF-alpha and lacks crossreactivity with human lymphotoxin.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614132986147,"sku":"HYBHM2009100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c567b83d-a861-4a16-80ae-0005faff2ef7.png?v=1753031060"},{"product_id":"tnf-alpha-human-mab-4h31-20-ug","title":"TNF-alpha, Human, mAb 4H31, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133018915,"sku":"HYBHM200920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8a55997e-b3bc-47a6-9d6e-7e3f8c0b5bf0.png?v=1753031063"},{"product_id":"tnf-alpha-human-mab-4h31-500-ug","title":"TNF-alpha, Human, mAb 4H31, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133051683,"sku":"HYBHM2009500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_31dff67d-d321-4e1f-a2a2-f77b21516d92.png?v=1753031066"},{"product_id":"tnf-alpha-human-mab-52b83","title":"TNF-alpha, Human, mAb 52B83","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 52B83 reacts with tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133084451,"sku":"HYBHM2010100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_72dd1b6d-2f1e-4f3d-a239-ecc7cc5d541b.png?v=1753031070"},{"product_id":"tnf-alpha-human-mab-52b83-20-ug","title":"TNF-alpha, Human, mAb 52B83, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614133117219,"sku":"HYBHM201020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_eb4c4316-3b23-4e07-b6bb-0524651e2e06.png?v=1753031073"},{"product_id":"tnf-alpha-human-mab-t1","title":"TNF-alpha, Human, mAb T1","description":"\u003cul\u003e\n\u003cli\u003eThe antibody reacts with free soluble (17 kDa) and membrane (26 kDa) human TNF-alpha. The antibody inhibits the biological activity of both forms. It does not react with receptor bound TNF-alpha. It can be a useful tool to discriminate between the membrane form of TNF expressed on producer cells and the proteolytically cleaved, soluble TNF-alpha bound to its cognate cell membrane receptors (TNF-RI and TNF-RII). For this purpose we recommend to use this antibody in combination with the anti-TNF-alpha antibody HM2026, which recognizes soluble, membrane and receptor bound TNF-alpha.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614134493475,"sku":"HYBHM2024100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_279483c3-e297-47ca-a906-6f777f0d76fb.png?v=1753031172"},{"product_id":"tnf-alpha-human-mab-t1-20-ug","title":"TNF-alpha, Human, mAb T1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614134526243,"sku":"HYBHM202420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a32f7930-8ac4-410f-909a-98432f6520f9.png?v=1753031176"},{"product_id":"tnf-alpha-human-mab-t3","title":"TNF-alpha, Human, mAb T3","description":"\u003cul\u003e\n\u003cli\u003eThe antibody reacts with free soluble (17 kDa) and membrane (26 kDa) human TNF-alpha. The antibody inhibits the biological activity of soluble and membrane TNF-alpha. The antibody can be a useful tool to discriminate between receptor bound soluble (17 kDa) and the membrane (26 kDa) form of TNF-alpha. For this purpose we recommend to use this antibody in combination with the anti-TNF-alpha antibody HM2024, which recognizes only soluble and membrane TNF-alpha, but not the receptor bound TNF-alpha.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614134657315,"sku":"HYBHM2026100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ec75c79a-346f-4100-9f56-a9a3fa9800c4.png?v=1753031184"},{"product_id":"tnf-alpha-human-mab-t3-20-ug","title":"TNF-alpha, Human, mAb T3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614134690083,"sku":"HYBHM202620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6bed386b-8dbf-49d2-9dce-a5293e9c7b9f.png?v=1753031171"},{"product_id":"tnf-alpha-human-mab-5n","title":"TNF-alpha, Human, mAb 5N","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 5N reacts with Tumor Necrosis Factor alpha (TNF-alpha). Tumor necrosis factor-alpha (TNF-alpha), a homotrimeric 17 KD protein, is a potent mediator of inflammatory and metabolic functions. TNF-alpha was originally detected as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Further TNF-alpha has been implied as central mediator in shock induced by gram negative micro-organisms. The cytokine TNF-alpha is found to be a central mediator in many inflammatory and immunological processes: it can be induced by various products of micro-organisms and by various cytokines but it also induces on its turn the production of many cytokines. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors I and II. The receptors differ strongly in their intra-cellular signaling pathways. The TNF-alpha trimer interacts with either of the two types of TNF-R leading to receptor cross-linking. The monoclonal antibody 5N cross-reacts and cross-neutralizes all monkey species TNF-alpha, except pig-tail macaque. With affinity about two orders lower it recognizes bovine and canine TNF-alpha.\u003c\/li\u003e\n\u003cli\u003eApplications: Functional Studies , Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150222115,"sku":"HYBHM2218100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8bee5b43-bcf5-492f-af7d-091204e61029.png?v=1753031752"},{"product_id":"tnf-alpha-human-mab-5n-20-ug","title":"TNF-alpha, Human, mAb 5N, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150254883,"sku":"HYBHM221820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_dcf22cb5-4d58-47a2-9283-377cb381ba0d.png?v=1753031756"},{"product_id":"tnf-alpha-human-mab-5n-500-ug","title":"TNF-alpha, Human, mAb 5N, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150287651,"sku":"HYBHM2218500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9381f5d9-b8f5-4af2-abb0-13dcd9824dd9.png?v=1753031759"}],"url":"https:\/\/chromspec.com\/collections\/15090-tnf-alpha.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}