{"title":"15097-IL-1ra3","description":"","products":[{"product_id":"il-1ra3-human-mab-2d11","title":"IL-1ra3, Human, mAb 2D11","description":"\u003cul\u003e\n\u003cli\u003eThe antibody reacts specificly with Human IL-1ra3. IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro-inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136623395,"sku":"HYBHM2055100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_fcf3f503-05a3-4575-9094-02fd361e60c2.png?v=1753031210"},{"product_id":"il-1ra3-human-mab-2d11-20-ug","title":"IL-1ra3, Human, mAb 2D11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614136656163,"sku":"HYBHM205520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c67a68a0-1f12-4120-bae0-26f7960bb8a1.png?v=1753031213"}],"url":"https:\/\/chromspec.com\/collections\/15097-il-1ra3.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}