{"title":"15101-TLR2","description":"","products":[{"product_id":"tlr2-human-mab-tl2-1-100-ug","title":"TLR2, Human, mAb TL2.1, 100 µg","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody TL2.1 recognizes human Toll-like receptor 2 (TLR2, CD282). Toll-like receptors (TLR) are highly conserved throughout evolution and are involved in the innate defence to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. In mammals, TLRs are identified as type I transmembrane signaling receptors with pattern recognition capabilities. They have been implicated in the innate host defence to pathogens. TLR2 is expressed on macrophages, smooth muscle, lung, spleen, thymus, brain and adipose tissue.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137442595,"sku":"HYBHM2064100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_faa4db4e-43e8-4ec9-a497-f13812ca959a.png?v=1753031273"},{"product_id":"tlr2-human-mab-tl2-1-10-mg","title":"TLR2, Human, mAb TL2.1, 10 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137475363,"sku":"HYBHM206410MG","price":14815.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6d4edb66-374d-4d5d-9e82-5fe25ca9e40a.png?v=1753031277"},{"product_id":"tlr2-human-mab-tl2-1-1-mg","title":"TLR2, Human, mAb TL2.1, 1 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137508131,"sku":"HYBHM20641MG","price":2965.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0b162faf-673f-4924-aeba-ef5280dbf2e5.png?v=1753031280"},{"product_id":"tlr2-human-mab-tl2-1","title":"TLR2, Human, mAb TL2.1","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137540899,"sku":"HYBHM206420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8e855ba4-207a-448a-8a06-f5c68def7fb8.png?v=1753031283"},{"product_id":"tlr2-human-mab-tl2-1-500-ug","title":"TLR2, Human, mAb TL2.1, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137573667,"sku":"HYBHM2064500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_54538f30-2770-4193-9729-fec527b4ead1.png?v=1753031287"},{"product_id":"tlr2-human-mab-tl2-1-5-mg","title":"TLR2, Human, mAb TL2.1, 5 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137639203,"sku":"HYBHM20645MG","price":11107.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d4dd9b79-9277-40bb-8ec7-1779191ce46e.png?v=1753031290"},{"product_id":"tlr2-human-mab-tl2-3","title":"TLR2, Human, mAb TL2.3","description":"\u003cul\u003e\n\u003cli\u003eToll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2 (CD282). The monoclonal antibody TL2.3 is specific for human TLR2 (CD282). TL2.3 is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human peripheral blood mononuclear cells. The monoclonal antibody TL23 is cross reactive with canine TLR2.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137770275,"sku":"HYBHM2066100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e431f940-63f2-413c-9de8-341d8b38922d.png?v=1753031299"},{"product_id":"tlr2-human-mab-tl2-3-20-ug","title":"TLR2, Human, mAb TL2.3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614137803043,"sku":"HYBHM206620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ad2f164c-3d04-4818-859c-98e4a3d3b0d5.png?v=1753031302"},{"product_id":"tlr2-human-mab-tlr2-45","title":"TLR2, Human, mAb TLR2.45","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody TLR2.45 recognizes human TLR2 (CD282). Toll-like receptors (TLR) are highly conserved throughout evolution and are implicated in the innate defense to many pathogens. Mammalian TLRs have been identified as type I transmembrane signaling receptors with pattern recognition capabilities. TLRs recognize pathogen-associated molecular patterns (PAMPs), expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Among TLRs, TLR2 is an unique receptor recognizing lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as peptidoglycan, lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2 (CD282). TLR2 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Furthermore, TLR2 is detected in lung and fetal liver. In other tissues TLR2 levels are low. The TLR2.45 monoclonal antibody is generated using Ba\/F3 cells which stably express human Flag-tagged TLR2.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunofluorescence\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150385955,"sku":"HYBHM2220100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f67bc0a5-1c51-4fea-8499-83e5102158af.png?v=1753031770"},{"product_id":"tlr2-human-mab-tlr2-45-20-ug","title":"TLR2, Human, mAb TLR2.45, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614150418723,"sku":"HYBHM222020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_583540a7-147f-48b4-bae3-0a44c346fdf8.png?v=1753031773"}],"url":"https:\/\/chromspec.com\/collections\/15101-tlr2.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}