{"title":"15105-C3 C3a","description":"","products":[{"product_id":"c3-c3a-human-mab-474","title":"C3\/C3a, Human, mAb 474","description":"\u003cul\u003e\u003cli\u003eMonoclonal antibody 474 reacts with an epitope on C3a. The antibody reacts both with intact C3 as with C3a. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. During complement activation, C3 is proteolytically cleaved resulting in release of the anaphylatoxic peptide C3a. C3a is a small polypeptide consisting of 74 amino acids (ca.10kDa). C3a itself is very short-lived and in serum cleaved rapidly into the more stable C3a-desArg (also called acylation stimulating protein, ASP) . C3a exerts its function through a specific receptor (C3aR), which belongs to the G-protein coupled receptor family. Expression of C3aR- has been reported in many cell types including myeloid and non-myeloid cells. Expression of C3aR on haematopoietic stem\/progenitor cells has been shown to promote the trafficking\/homing of these cells to the BM. Engagement of C3aR on DCs and T cells has been shown to up-regulate these cell functions.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138425635,"sku":"HYBHM2073100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e591d7f4-d5ee-4279-9aae-0da74764e7ef.png?v=1753031342"},{"product_id":"c3-c3a-human-mab-474-20-ug","title":"C3\/C3a, Human, mAb 474, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138458403,"sku":"HYBHM207320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_404214c1-9116-43aa-8d08-81f53dfe431c.png?v=1753031345"},{"product_id":"c3-c3a-human-mab-474-500-ug","title":"C3\/C3a, Human, mAb 474, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138491171,"sku":"HYBHM2073500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6a6ce401-7e19-4ab0-83bd-1470b857dcc7.png?v=1753031348"},{"product_id":"c3-c3a-human-mab-474-biotin-50-ug","title":"C3\/C3a, Human, mAb 474, Biotin, 50 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138523939,"sku":"HYBHM2073BT50UG","price":484.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1f271b37-ca27-4055-b926-e070757a34f2.png?v=1753031352"},{"product_id":"c3-c3a-human-mab-2898","title":"C3\/C3a, Human, mAb 2898","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 2898 recognizes the C-terminus of human complement protein C3a. The antibody recognizes intact C3, C3a as well as C3a-desArg. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg\/ml. The complement system is an important part of the humoral response in innate immunity, consisting of three different pathways. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. Monoclonal antibodies detecting neo-epitopes have been used for direct quantification of activation at different steps in the complement cascade. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. In ulcerative colitis, and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by certain enzymes results in the cleavage of C3 releasing C3a anaphylatoxin and C3b. C3a is a protein of 74 amino acids. C3a itself is very short-lived and in serum is cleaved rapidly into the more stable C3a-desArg (also called acylation stimulating protein, ASP). Therefore, measurement of C3a-desArg allows reliable conclusions about the level of complement activation in the test samples.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138687779,"sku":"HYBHM2075100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_dd810745-e4b5-4616-86e6-ba9136daac25.png?v=1753031365"},{"product_id":"c3-c3a-human-mab-2898-20-ug","title":"C3\/C3a, Human, mAb 2898, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138720547,"sku":"HYBHM207520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2c5c5ebc-7db8-44ea-9250-ce27e25ff5cc.png?v=1753031368"},{"product_id":"c3-c3a-human-mab-2898-500-ug","title":"C3\/C3a, Human, mAb 2898, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614138753315,"sku":"HYBHM2075500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0eea6544-b1d4-42fa-be11-d80492683ccb.png?v=1753031372"}],"url":"https:\/\/chromspec.com\/collections\/15105-c3-c3a.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}