{"title":"15143-Protein S","description":"","products":[{"product_id":"protein-s-human-mab-ps7","title":"Protein S, Human, mAb PS7","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa. In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain. Monoclonal antibody PS7 allows specific detection of cells carrying PS by flow cytometry.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143635747,"sku":"HYBHM2148100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4b24c2c4-22ed-4113-8b3c-92b8c0537462.png?v=1753031527"},{"product_id":"protein-s-human-mab-ps7-20-ug","title":"Protein S, Human, mAb PS7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614143668515,"sku":"HYBHM214820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a319256e-f079-43e1-9db8-48e36be9f2f1.png?v=1753031530"}],"url":"https:\/\/chromspec.com\/collections\/15143-protein-s.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}