{"title":"15158-Galectin-3","description":"","products":[{"product_id":"galectin-3-human-mab-b2c10-100-ug","title":"Galectin-3, Human, mAb B2C10, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody B2C10 reacts with galectin-3, a 30 kDa protein. Galectin-3 is a member of the galectin family. The protein is composed of three domains: a small amino-terminal domain, a carboxyl-terminal carbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. The expression is also affected by neoplastic transformation: up-regulated in certain types of lymphomas and thyroid carcinoma, while down-regulated in other types of malignancies, such as colon, breast, ovarian and uterine carcinomas. Galectin-3 has been shown to function through both intracellular and extracellular actions. Related to its intracellular functions, galectin-3 has been identified as a component of heterogeneous nuclear ribonuclear protein (hnRNP), a factor in pre-mRNA splicing, and has been found to control cell cycle and prevent T cell apoptosis. On the other hand, this protein has also been demonstrated to function as extracellular molecule in activating various types of cells, including monocytes\/macrophages, mast cells, neutrophils and lymphocytes. Galectin-3 has been shown to mediate cell-cell and cell-extracellular matrix interactions. The monoclonal antibody B2C10 inhibits the binding of 125I-labeled galectin-3 to IgE coated on microtiter plates, the galecin-3's hemagglutination activity and galectin-3-induced superoxide production by human neutrophils. This inhibitory activity of B2C10 is probably the result of its disruption of the self-association process. The epitope of the monoclonal antibody B2C10 is found within the first 45 amino acids of galectin-3. The antibody B2C10 does not react with Galecin-3C and is cross reactive with mouse galectin-3.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614145995043,"sku":"HYBHM2186100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_42aaca38-9a8e-44ae-b00b-0cbaccf1026b.png?v=1753031735"},{"product_id":"galectin-3-human-mab-b2c10-10-mg","title":"Galectin-3, Human, mAb B2C10, 10 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148387107,"sku":"HYBHM218610MG","price":14815.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d06e85d5-78de-4134-b234-ee202301687b.png?v=1753031738"},{"product_id":"galectin-3-human-mab-b2c10-1-mg","title":"Galectin-3, Human, mAb B2C10, 1 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148419875,"sku":"HYBHM21861MG","price":2965.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_75deef2c-4939-4132-9ce4-1be6b56ad830.png?v=1753031742"},{"product_id":"galectin-3-human-mab-b2c10","title":"Galectin-3, Human, mAb B2C10","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148452643,"sku":"HYBHM218620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3ad3f15c-4398-49d4-a383-d5298b61bd48.png?v=1753031745"},{"product_id":"galectin-3-human-mab-b2c10-500-ug","title":"Galectin-3, Human, mAb B2C10, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148485411,"sku":"HYBHM2186500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_daeeabbe-f4db-43bd-b4bd-38d5e60c4322.png?v=1753031748"},{"product_id":"galectin-3-human-mab-b2c10-5-mg","title":"Galectin-3, Human, mAb B2C10, 5 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614148518179,"sku":"HYBHM21865MG","price":11107.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d4b077bc-dfa1-4806-86ca-30d6c250bd27.png?v=1753031752"}],"url":"https:\/\/chromspec.com\/collections\/15158-galectin-3.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}