{"title":"15167-C3c","description":"","products":[{"product_id":"c3c-human-mab-4","title":"C3c, Human, mAb 4","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 4 recognizes the cleaved human C3 fragment C3c. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg\/ml. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. The monoclonal antibody 4 recognizes a conformational epitope in C3c, C3b and iC3b.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoprecipitation\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149239075,"sku":"HYBHM2200100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9561cf6b-8bad-4ce6-8333-b97f7a0c313a.png?v=1753031658"},{"product_id":"c3c-human-mab-4-20-ug","title":"C3c, Human, mAb 4, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614149271843,"sku":"HYBHM220020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a6a4e85c-7096-408e-b363-a2414134380c.png?v=1753031661"},{"product_id":"c3c-human-mab-f1-4","title":"C3c, Human, mAb F1-4","description":"\u003cul\u003e\u003cli\u003eAntibody F1-4 recognizes a unique epitope exclusively present on human complement C3c. The complement system mediates a number of essential biological functions that participate in host defense against infection, initiation of the inflammatory reaction, processing and clearance of immune complexes and regulation of the immune response. There are three pathways of complement activation: the classical pathway is initiated by immune complexes, the lectin pathway by surface bound mannan binding lectin and the alternative pathway by all the surfaces that are not specifically protected against it. Each of the complement pathway generates a C3 convertase, a serine protease that cleaves the central complement protein C3, and generates the major cleavage fragment C3b. C3b is an opsonin and part of one of the main convertases that drives the complement cascade. In the presence of complement regulatory molecules C3b may be further degraded sequentially to iC3b, C3c, C3dg and C3d. The disadvantage of most complement biomarkers is their short half-life, making reliable sample collection and measurements difficult. Unlike other C3 fragments, C3c does not bind to other structures, like pathogens, cell surface (receptors) and other plasma proteins. Therefore, C3c is a stable complement biomarker which will appear in the fluid phase only, without interference of other C3 based products. The measurement of C3c provides evidence of (uncontrolled) complement activation and can be used as an indicator of an inflammatory state. The complement is a key element of the innate immune system. In appropriate activation is pathologic and leads eg. To various autoimmune diseases, like HUS. There are also indications that C3 is associated with the cardiovascular system and Parkinson’s disease, making C3c a reliable and useful biomarker.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155464995,"sku":"HYBHM2318100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_73af3ad5-63cc-478f-856c-eb2b435dbc15.png?v=1753032088"},{"product_id":"c3c-human-mab-f1-4-20-ug","title":"C3c, Human, mAb F1-4, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614155497763,"sku":"HYBHM231820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1061c603-3527-4e67-b522-62a3fb33e292.png?v=1753032091"}],"url":"https:\/\/chromspec.com\/collections\/15167-c3c.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}