{"title":"15183-SI-CLP","description":"","products":[{"product_id":"si-clp-human-mab-1c11","title":"SI-CLP, Human, mAb 1C11","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 1C11 recognizes human stabilin-1 interacting chitinase-like protein (SI-CLP). SI-CLP is a 39 kD member of the family of Glyco_18-domain-containing proteins. These chitinase-like proteins are involved primarily in Th2-associated disorders and tumor progression. Chitinase-like proteins are soluble mediators of cell differentiation, proliferation, activation, migration, and adherence. Chitinase like protein SI-CLP is a stabilin-1 interacting partner. SI-CLP gene expression was up-regulated by IL-4 and dexamethasone on the mRNA and protein levels in primary human macrophages in parallel with the expression of stabilin-1. The major site of SI-CLP intracellular localization is in Lamp1-positive and secretion commited CD63+ secretory lysosomes. The endocytic\/sorting receptor stabilin-1 is a highly specific intracellular sorting receptor for SI-CLP. SI-CLP directly binds to, and colocalizes with stabilin-1. The lysosomal localization of SI-CLP in stabilin-1-negative macrophages, however, indicates that stabilin-1 may not be the only receptor mediating trafficking of newly synthesized SI-CLP. In vivo, the monoclonal antibody 1C11 recognizes SI-CLP in the cellular fraction of bronchoalveolar lavage specimens obtained from patients with chronic inflammatory disorders of the respiratory tract and in peripheral-blood leukocytes (PBLs) from these patients as well as healthy donors.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunofluorescence , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614151205155,"sku":"HYBHM2240100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_35e23c85-e987-4c10-a0b7-4d1e2474320f.png?v=1753031846"},{"product_id":"si-clp-human-mab-1c11-20-ug","title":"SI-CLP, Human, mAb 1C11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614151237923,"sku":"HYBHM224020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e03d55e4-69f4-4710-8a6f-d57a85160e59.png?v=1753031850"}],"url":"https:\/\/chromspec.com\/collections\/15183-si-clp.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}