{"title":"15195-C7","description":"","products":[{"product_id":"c7-human-mab-wu-4-15","title":"C7, Human, mAb WU 4-15","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody WU 4-15 recognizes C7, one of the components of the terminal complement complex (TCC), also know as the membrane attack complex (MAC). Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 MAC. This complex is assembled from five precursor molecules in the serum, finalized with the polymerization of C9 which accompanies insertion of the complex into the cell membrane causing cellular lysis. C7 occupies an important position in the TCC cascade. C7 undergoes a hydrophilic-amphiphilic transition following activation. It enables the developing MAC to bind directly to target cell membranes. C7 has been shown to exhibit genetic polymorphism. Polymorphonuclear leukocytes represent a major source of C7. The fact that inflammatory cells have the potential to secrete C7 suggests an important role for locally produced complement in the inflammatory process. The monoclonal antibody WU 4-15 identifies an specific allotype of C7: C7 M. 62% of the caucasians is homozygous for C7 M, 31% heterozygous. Antibody Wu 4-15 enables to quantify the contribution of locally synthesized C7 to the inflammatory process and to identify the allotype.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Immunofluorescence , Immunoprecipitation , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614152941859,"sku":"HYBHM2277100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d40cd95f-3360-45d2-857f-24d95a353c67.png?v=1753031857"},{"product_id":"c7-human-mab-wu-4-15-20-ug","title":"C7, Human, mAb WU 4-15, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614152974627,"sku":"HYBHM227720UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_87aeb6bb-1c77-44f7-b251-c53aad90a43b.png?v=1753031860"},{"product_id":"c7-human-clone-hb2h-100-ug","title":"C7, Human, clone HB2H, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eAntibody HM2421 clone HB2H recognizes human complement C7 in its native form.Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces. However, its precise regulatory role in complement is poorly understood.\u003c\/li\u003e\n\u003cli\u003eThe main function of C7 is stabilizing the C5b6 complex after initiation of the terminal pathway. It is primarily synthesized extrahepatically at the site of inflammation by granulocytes and endothelial cells, thereby modulating lytic or sublytic membrane attack. Mutations in the C7 gene are associated with a rare disorder called C7 deficiency andaffected individuals predisposed to angioedema, collagen vascular disease, or infections.\u003c\/li\u003e\n\u003cli\u003eBesides functioning as a single protein and its role in MAC formation, C7 might also form complexes with other proteins indicating potential regulatory functions.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161723683,"sku":"HYBHM2421100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_58580102-1d34-4674-a4ec-6b0dbead1057.png?v=1753032160"},{"product_id":"c7-human-clone-hb2h-20-ug","title":"C7, Human, clone HB2H, 20 µg","description":"\u003cul\u003e\n\u003cli\u003eAntibody HM2421 clone HB2H recognizes human complement C7 in its native form.Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces. However, its precise regulatory role in complement is poorly understood.\u003c\/li\u003e\n\u003cli\u003eThe main function of C7 is stabilizing the C5b6 complex after initiation of the terminal pathway. It is primarily synthesized extrahepatically at the site of inflammation by granulocytes and endothelial cells, thereby modulating lytic or sublytic membrane attack. Mutations in the C7 gene are associated with a rare disorder called C7 deficiency andaffected individuals predisposed to angioedema, collagen vascular disease, or infections.\u003c\/li\u003e\n\u003cli\u003eBesides functioning as a single protein and its role in MAC formation, C7 might also form complexes with other proteins indicating potential regulatory functions.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161756451,"sku":"HYBHM242120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6433bb03-2d65-4fa7-b342-44210b94b0dd.png?v=1753032163"},{"product_id":"c7-human-clone-hb10g-100-ug","title":"C7, Human, clone HB10G, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eAntibody HM2425 clone HB10G recognizes human complement C7 in its native form. Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces. However, its precise regulatory role in complement is poorly understood.\u003c\/li\u003e\n\u003cli\u003eThe main function of C7 is stabilizing the C5b6 complex after initiation of the terminal pathway. It is primarily synthesized extrahepatically at the site of inflammation by granulocytes and endothelial cells, thereby modulating lytic or sublytic membrane attack. Mutations in the C7 gene are associated with a rare disorder called C7 deficiency and affected individuals predisposed to angioedema, collagen vascular disease, or infections. Besides functioning as a single protein and its role in MAC formation, C7 might also form complexes with other proteins indicating potential regulatory functions.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161854755,"sku":"HYBHM2425100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5812b834-1e0b-4393-834f-424315e15783.png?v=1753032173"},{"product_id":"c7-human-clone-hb10g-20-ug","title":"C7, Human, clone HB10G, 20 µg","description":"\u003cul\u003e\n\u003cli\u003eAntibody HM2425 clone HB10G recognizes human complement C7 in its native form. Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces. However, its precise regulatory role in complement is poorly understood.\u003c\/li\u003e\n\u003cli\u003eThe main function of C7 is stabilizing the C5b6 complex after initiation of the terminal pathway. It is primarily synthesized extrahepatically at the site of inflammation by granulocytes and endothelial cells, thereby modulating lytic or sublytic membrane attack. Mutations in the C7 gene are associated with a rare disorder called C7 deficiency and affected individuals predisposed to angioedema, collagen vascular disease, or infections. Besides functioning as a single protein and its role in MAC formation, C7 might also form complexes with other proteins indicating potential regulatory functions.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161887523,"sku":"HYBHM242520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_914dbd75-119b-4320-9cbd-c780b14f5c70.png?v=1753032176"},{"product_id":"c7-human-clone-hb10h-100-ug","title":"C7, Human, clone HB10H, 100 µg","description":"\u003cul\u003e\n\u003cli\u003eAntibody HM2426 clone HB10H recognizes human complement C7 in its native form. Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces. However, its precise regulatory role in complement is poorly understood.\u003c\/li\u003e\n\u003cli\u003eThe main function of C7 is stabilizing the C5b6 complex after initiation of the terminal pathway. It is primarily synthesized extrahepatically at the site of inflammation by granulocytes and endothelial cells, thereby modulating lytic or sublytic membrane attack. Mutations in the C7 gene are associated with a rare disorder called C7 deficiency and affected individuals predisposed to angioedema, collagen vascular disease, or infections.\u003c\/li\u003e\n\u003cli\u003eBesides functioning as a single protein and its role in MAC formation, C7 might also form complexes with other proteins indicating potential regulatory functions.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161920291,"sku":"HYBHM2426100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_9ecd0069-aef8-4d54-848c-9f1f0cfc0529.png?v=1753032179"},{"product_id":"c7-human-clone-hb10h-20-ug","title":"C7, Human, clone HB10H, 20 µg","description":"\u003cul\u003e\n\u003cli\u003eAntibody HM2426 clone HB10H recognizes human complement C7 in its native form. Complement component C7 is an important complement protein that acts as a driving or limiting factor for the assembly of the membrane attack complex on local surfaces. However, its precise regulatory role in complement is poorly understood.\u003c\/li\u003e\n\u003cli\u003eThe main function of C7 is stabilizing the C5b6 complex after initiation of the terminal pathway. It is primarily synthesized extrahepatically at the site of inflammation by granulocytes and endothelial cells, thereby modulating lytic or sublytic membrane attack. Mutations in the C7 gene are associated with a rare disorder called C7 deficiency and affected individuals predisposed to angioedema, collagen vascular disease, or infections.\u003c\/li\u003e\n\u003cli\u003eBesides functioning as a single protein and its role in MAC formation, C7 might also form complexes with other proteins indicating potential regulatory functions.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614161953059,"sku":"HYBHM242620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f1469f2d-a716-4a15-ac13-cbc7250b4a65.png?v=1753032183"}],"url":"https:\/\/chromspec.com\/collections\/15195-c7.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}