{"title":"15199-Properdin","description":"","products":[{"product_id":"properdin-human-mab-2-9","title":"Properdin, Human, mAb 2.9","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 2.9 reacts with human properdin (factor P), which is a single-chain plasmaglycoprotein with an apparent molecular mass of 52-55 kDa, The protein domain structure ofproperdin consists of six thrombospondin repeat sequences between short N- and C-terminaldomains. In blood, properdin exists as a mixture of head-to-tail dimers, trimers and tetramers. Theprotein is expressed by a variety of leukocytes, including monocytes, T lymphocytes and neutrophils,but also by endothelial cells in which properdin synthesis is induced by certain stress factors.Properdin participates in the alternative pathway of complement activation together with C3 andfactors B, D, I and H by prolonging the half-life of the labile C3bBb, which is deposited on immunecomplexes or foreign surfaces. This permits amplification of C3bBb formation in competition withcatabolism of C3b by factor I, which uses factor H as a cofactor. The local amplification process leadsto the creation of the alternative pathway C5 convertase, C3bBb3b, and initiates the terminal pathwayof complement activation. As a consequence, properdin is consumed by binding to C3bBb, whichshows an order of preference of tetramers over trimers over dimers, which corresponds to thefunctional activity of the oligomeric forms. Deficiency or malfunction of the molecule may lead tosevere impairment of alternative pathway activation, depending on the precise nature of the defect.Three types of deficiencies have been described so far: type 1 (or I) is characterized by serum withvery low or absent properdin activity in hemolytic assays and \u0026lt; 0.1 μg\/ml immunoreactive protein; type2 (or II) is characterized by low but detectable levels of immunoreactive protein (\u0026gt;2 μg\/ml) andimpairment of some, but not all functional test, and type 3 (or III) has normal levels of immunoreactivebut dysfunctional protein (5-25 μg\/mL). Lower properdin levels were found in 70% of diabetic patientswhen compared to nondiabetic controls and is suggested by the authors that patients with lowexpression of properdin take preventive measures and early treatments against infection. Themonoclonal antibody 2.9 is suitable for functional studies as well as use in immunoassays.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153204003,"sku":"HYBHM2282100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_79a5f5fc-7d1a-40cd-ab62-0e297c75e018.png?v=1753031883"},{"product_id":"properdin-human-mab-2-9-20-ug","title":"Properdin, Human, mAb 2.9, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153236771,"sku":"HYBHM228220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_fbf4149d-107f-4b18-a6fd-c06888eb5f9c.png?v=1753031887"},{"product_id":"properdin-human-mab-sim295-9-3-4","title":"Properdin, Human, mAb SIM295-9.3.4","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody SIM 295-9.3.4 reacts with human properdin (factor P), which is a single-chain plasma glycoprotein with an apparent molecular mass of 52-55 kDa. The protein domain structure of properdin consists of six thrombospondin repeat sequences between short N- and C-terminal domains. In blood, properdin exists as a mixture of head-to-tail dimers, trimers and tetramers. The protein is expressed by a variety of leukocytes, including monocytes, T lymphocytes and neutrophils, but also by endothelial cells in which properdin synthesis is induced by certain stress factors. Properdin participates in the alternative pathway of complement activation together with C3 and factors B, D, I and H by prolonging the half-life of the labile C3bBb, which is deposited on immune complexes or foreign surfaces. This permits amplification of C3bBb formation in competition with catabolism of C3b by factor I, which uses factor H as a cofactor. The local amplification process leads to the creation of the alternative pathway C5 convertase, C3bBb3b, and initiates the terminal pathway of complement activation. As a consequence, properdin is consumed by binding to C3bBb, which shows an order of preference of tetramers over trimers over dimers, which corresponds to the functional activity of the oligomeric forms. Deficiency or malfunction of the molecule may lead to severe impairment of alternative pathway activation, depending on the precise nature of the defect. Three types of deficiencies have been described so far: type 1 (or I) is characterized by serum with very low or absent properdin activity in hemolytic assays and \u0026lt;0.1 μg\/ml immunoreactive protein; type 2 (or II) is characterized by low but detectable levels of immunoreactive protein (\u0026gt;2 μg\/ml) and impairment of some, but not all functional test, and type 3 (or III) has normal levels of immunoreactive but dysfunctional protein (5-25 μg\/mL). Lower properdin levels were found in 70% of diabetic patients when compared to nondiabetic controls and is suggested by the authors that patients with low expression of properdin take preventive measures and early treatments against infection. The monoclonal antibody SIM 295-9.3.4 is suitable for flow cytometry, immunohistochemistry, western blotting as well as use in immunoassays. \u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153269539,"sku":"HYBHM2283100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c05f3194-7ff0-4d18-b2db-f8afca93c728.png?v=1753031890"},{"product_id":"properdin-human-mab-sim295-9-3-4-20-ug","title":"Properdin, Human, mAb SIM295-9.3.4, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614153302307,"sku":"HYBHM228320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1276bd19-1990-4fda-82d1-734506900510.png?v=1753031893"},{"product_id":"properdin-human-mab-1g6d2","title":"Properdin, Human, mAb 1G6D2","description":"\u003cul\u003e\n\u003cli\u003eRecognizes human properdin, also called complement factor P.\u003c\/li\u003e\n\u003cli\u003eAntibody 1G6D2 can be used in ELISA, western blotting (only non-reduced) and as negative control antibody for functional studies inhibiting the alternative pathway of complement.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156448035,"sku":"HYBHM2354100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_296f7f20-8660-4856-96ea-b0c66b86426a.png?v=1753032050"},{"product_id":"properdin-human-mab-1g6d2-20-ug","title":"Properdin, Human, mAb 1G6D2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156480803,"sku":"HYBHM235420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8742ed92-f81d-432c-bedc-8d17120290a4.png?v=1753032053"},{"product_id":"properdin-human-mab-1g6d2-500-ug","title":"Properdin, Human, mAb 1G6D2, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156513571,"sku":"HYBHM2354500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_60498a8a-ada0-4354-99de-fd6bae2995c9.png?v=1753032057"},{"product_id":"properdin-human-mab-3a3e1","title":"Properdin, Human, mAb 3A3E1","description":"\u003cp\u003eAntibody 3A3E1 can be used in ELISA, western blotting (only non-reduced) and as antibody for functional studies inhibiting the alternative pathway of complement, like the standard erythrocyte AP50 assay.\u003c\/p\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156546339,"sku":"HYBHM2355100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_609bcfef-d7bb-4092-b633-863e878e75de.png?v=1753032060"},{"product_id":"properdin-human-mab-3a3e1-20-ug","title":"Properdin, Human, mAb 3A3E1, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156579107,"sku":"HYBHM235520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d221317e-9e41-42c6-b638-59c6e2ae1140.png?v=1753032064"},{"product_id":"properdin-human-mab-3a3e1-500-ug","title":"Properdin, Human, mAb 3A3E1, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614156611875,"sku":"HYBHM2355500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_47e0c6c5-8a33-4c4b-835b-c89ea82b358f.png?v=1753032067"}],"url":"https:\/\/chromspec.com\/collections\/15199-properdin.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}