{"title":"15264-Activated C1s","description":"","products":[{"product_id":"activated-c1s-human-mab-m241","title":"Activated C1s, Human, mAb M241","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and\/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614141276451,"sku":"HYBHM2109100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e41b82ce-1193-48c7-be9d-fdbed83629c6.png?v=1753031459"},{"product_id":"activated-c1s-human-mab-m241-20-ug","title":"Activated C1s, Human, mAb M241, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614141309219,"sku":"HYBHM210920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_905cd4a0-ccd0-4a8f-8f6f-2e1dac4d3bc0.png?v=1753031462"}],"url":"https:\/\/chromspec.com\/collections\/15264-activated-c1s.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}