{"title":"15482-Antibody Name F","description":"","products":[{"product_id":"fibroblasts-mouse-mab-er-tr7","title":"Fibroblasts, Mouse, mAb ER-TR7","description":"\u003cul\u003e\u003cli\u003eMonoclonal antibody ER-TR7 recognizes with an intracellular component of mouse fibroblasts. Fibroblasts are the least specialized cells in the connective-tissue family. They are dispersed in connective tissue throughout the body, where they secrete a nonrigid extracellular matrix (ECM) that is rich in type I and\/or type III collagen. Conective tissue consists of glycosaminoglycans, proteoglycans and glycoproteins through which various fibres run. These fibres can be collagenous, elastic or reticular. Reticular fibres are composed from the family of collagen proteins and give tensile strength. These fibres are made by reticular fibroblasts. The activation of fibroblasts by inflammatory stimuli results in their migration, proliferation and deposition of extracellular matrix components, important features involved in both wound healing and fibrosis.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126432547,"sku":"HYBHM1086100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f72d3864-0896-4cbe-bb11-ea02ea6e1eac.png?v=1753030833"},{"product_id":"fibroblasts-mouse-mab-er-tr7-20-ug","title":"Fibroblasts, Mouse, mAb ER-TR7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126465315,"sku":"HYBHM108620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3a824bbd-a1eb-47af-b99b-79be2a741e01.png?v=1753030836"},{"product_id":"factor-h-mouse-mab-1a2","title":"Factor H, Mouse, mAb 1A2","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody 1A2 recognizes mouse complement factor H (CFH). CFH is the first regulatory protein of the alternative pathway of the complement system. There are three pathways of complement activation; classical, alternative, and lectin activation pathway. These pathways converge to form C3\/C5 convertases that generate C3a, C3b,C5a, and C5b, each with substantial biologic activity. Complement regulators are necessary to prevent the injudicious production of these mediators and potential injury to self-tissue. The plasma proteins CFH, C4-binding protein and the cell membrane proteins complement receptor 1 (CR1; CD35), decay-accelerating factor (CD55), and membrane co-factor protein (CD46) all are members of the regulators of complement activation family. These proteins have natural affinity for C3b and\/or C4b, which confers on them the ability to accelerate the intrinsic decay of C3\/C5 convertases and\/or act as co-factor for the cleavage and inactivation (i) of C3b and C4b by complement factor I (CFI). Genetic human analyses reveals a clear association of CFH with different human diseases. These include diseases of the kidney, the atypical form of Hemolytic Uremic Syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN). Furthermore, CFH is associated with age-related macular degeneration (AMD), a disease of the eye.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614130135331,"sku":"HYBHM1119100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8ad78c6e-b9fc-4474-93e6-e5e357316e3e.png?v=1753030946"},{"product_id":"factor-h-mouse-mab-1a2-20-ug","title":"Factor H, Mouse, mAb 1A2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614130168099,"sku":"HYBHM111920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e326a8ae-87c1-427b-9904-fe47305a3f28.png?v=1753030949"}],"url":"https:\/\/chromspec.com\/collections\/15482-antibody-name-f.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}