{"title":"15498-Antibody Name L","description":"","products":[{"product_id":"lbp-mouse-mab-m330-19","title":"LBP, Mouse, mAb M330-19","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody M330-19 reacts highly specific with mouse natural and recombinant LBP. The antibody is a type I antibody blocking the LPS binding to LBP. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614118207779,"sku":"HYBHM1026100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c126cbeb-5a2f-470c-b5fb-40658c9f5d79.png?v=1753030619"},{"product_id":"lbp-mouse-mab-m330-19-20-ug","title":"LBP, Mouse, mAb M330-19, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614118240547,"sku":"HYBHM102620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_df1ea1ab-2b9f-4aef-9048-100cbd1333da.png?v=1753030623"},{"product_id":"lbp-mouse-mab-rr433-8","title":"LBP, Mouse, mAb RR433-8","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody RR433-8 reacts highly specific with mouse natural and recombinant LBP. The antibody is a type II antibody blocking the LPS binding to CD14. LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614118273315,"sku":"HYBHM1027100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_3cc040a6-5ad6-438c-ae41-30ec4e4ece55.png?v=1753030626"},{"product_id":"lbp-mouse-mab-rr433-8-20-ug","title":"LBP, Mouse, mAb RR433-8, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614118437155,"sku":"HYBHM102720UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b4f59ab6-05ec-4c7c-9b5c-16c22e14da89.png?v=1753030629"},{"product_id":"ltbeta-receptor-mouse-mab-5g11","title":"LTbeta receptor, Mouse, mAb 5G11","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 5G11 reacts with the mouse lymphotoxin beta-receptor (LTbetaR), a member of the tumor necrosis factor (TNF) family. This receptor can be activated by its functional ligands lymphotoxin-alpha1-beta2 (LT-alpha1beta2) and LIGHT and is critically involved in controlling bacterial infections. In Mycobacterium infection, its role is related to bactericidal granuloma formation in the spleen, macrophage differentiation and the maintenance of the appropriate Th1\/Th2 cytokine balance. In CMV infection, LTbetaR signaling induces the expression of IFN-beta in infected fibroblasts, resulting in viral stasis. LTbetaR plays an important role in lymphoid organogenesis and tumor development. The receptor is expressed on fibroblasts and stromal cells and at low levels in some myeloid cell lines. In the adult animal, the LTbetaR seems to be necessary for maintaining the splenic architecture and aspects of Ig formation and B cell follicular structure. When the LT-alpha1beta2\/LTbetaR pathway is disrupted by genetic deletion, mice completely lack Peyer's patches. Also, LTbetaR induces cell death in some adenocarcinoma tumor lines in the presence of IFNgamma. The monoclonal antibody 5G11 directed against the mouse LTbetaR is able to activate the LTbetaR in an agonistic way and induces NFkappaB activation and secretion of MIP-2 and IL-6 in mouse fibroblast cells. Therefore, the monoclonal antibody 5G11 can be used to gain more insight into the expression pattern of the LTbetaR and also to investigate molecular mechanisms induced by LTbetaR activation.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Functional Studies , Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614125941027,"sku":"HYBHM1079100UG","price":1086.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_15b5ee07-d386-4af6-a566-0613833ed432.png?v=1753030779"},{"product_id":"ltbeta-receptor-mouse-mab-5g11-10-mg","title":"LTbeta receptor, Mouse, mAb 5G11, 10 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614125973795,"sku":"HYBHM107910MG","price":14815.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ec12dfa6-8f96-424f-a589-08698da65276.png?v=1753030783"},{"product_id":"ltbeta-receptor-mouse-mab-5g11-1-mg","title":"LTbeta receptor, Mouse, mAb 5G11, 1 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126006563,"sku":"HYBHM10791MG","price":2965.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_eb9a6681-6910-484f-8309-c5dc0eaac51b.png?v=1753030786"},{"product_id":"ltbeta-receptor-mouse-mab-5g11-20-ug","title":"LTbeta receptor, Mouse, mAb 5G11, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126039331,"sku":"HYBHM107920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6b1eabc4-591e-4648-bd88-1d694bdfa120.png?v=1753030789"},{"product_id":"ltbeta-receptor-mouse-mab-5g11-500-ug","title":"LTbeta receptor, Mouse, mAb 5G11, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126072099,"sku":"HYBHM1079500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ab9a2005-175c-41c9-ad07-0d1f90ab6e2d.png?v=1753030792"},{"product_id":"ltbeta-receptor-mouse-mab-5g11-5-mg","title":"LTbeta receptor, Mouse, mAb 5G11, 5 mg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126104867,"sku":"HYBHM10795MG","price":11107.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_055ec148-f6c2-479b-be54-c050fbc9db83.png?v=1753030796"},{"product_id":"ly-6c-mouse-mab-er-mp20","title":"Ly-6C, Mouse, mAb ER-MP20","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody ER-MP20 specifically reacts with mouse macrophage precursor cells in the mid-stage of their development (late CFU-M, monoblasts and monocytes). The antigen is a 14 kD surface protein which is very similar to Ly-6C and may be analogous to human CD59. It is inducible by IFN-alpha, IFN-beta and IFN-gamma. In tissue sections, the antigen is found on macrophage precursor subpopulations. In the bone marrow and hemopoietic islands of the lymphoid organs, and in the spleen. Activated macrophages in inflammatory tissues also express the ER-MP20-related antigen. The monoclonal antibody ER-MP20 has been raised after immunization of rats with mouse macrophage cell lines and reacts with mouse macrophage precursor cells. The monoclonal antibody also identifies activated macrophages in inflammatory tissues where the simultaneous use of the murine pan-macrophage marker BM8 (anti-F4\/80) is recommended. In combination with an anti-mouse CD31\/PECAM-1 antibody, ER-MP20 can be used to evaluate the cellular composition in murine bone marrow (e.g. using flow cytometric analysis). ER-MP20 also detects a wide range of endothelial cells.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Immunoassays , Paraffin Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126235939,"sku":"HYBHM1082100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1d5bf234-fad0-4156-a7b3-26698e41a95f.png?v=1753030810"},{"product_id":"ly-6c-mouse-mab-er-mp20-20-ug","title":"Ly-6C, Mouse, mAb ER-MP20, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126268707,"sku":"HYBHM108220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_11d96942-b2d6-4a71-a666-04e1509c3c75.png?v=1753030815"},{"product_id":"lactoferrin-mouse-mab-1a10","title":"Lactoferrin, Mouse, mAb 1A10","description":"\u003cul\u003e\n\u003cli\u003eMonoclonal antibody clone 1A10 recognizes mouse lactoferrin (LF). The expression of small proteins and peptides with microbial activity, also called antimicrobial peptides (AMPs), is considered to be a primitive mechanism of immunity. AMPs are produced by almost all cell types which are commonly exposed to microbes. Lactoferrin is a multifunctional AMP and a major element of innate immunity but also affects adaptive immune functions. LF is a well conserved mammalian non-haem iron-binding 80kD monomeric glycoprotein of the transferrin family. The protein is found in mucosal secretion like saliva, tears, urine, vaginal fluids, semen, urine and very high concentrations in (colostral) milk (1-7mg\/ml). Its protective effects range from direct antimicrobial activities against a large panel of microorganisms, including bacteria, viruses, fungi and parasites, to anti-inflammatory and anticancer activities. The main functions of LF resided in specific domains and have predominantly be found in the N-terminal side. One of the main functions is inhibition of microbial growth by sequestration of iron, which is essential for growth. The N-terminal structure of LF is mainly responsible for this function. The N-terminal domain contains also a serine- protease-like activity which is involved in inactivation of host cell invasion by bacteria. Following infection, LF is released from secondary- granules of neutrophils in blood and inflamed tissue and functions as pattern-recognition receptor. Therefore, LF plasma concentration represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover and can be used as an index for neutrophil activation. In the adaptive immune response, LF promotes the maturation of T-cell precursors into competent helper cells and by differentiation of immature B-cells into antigen presenting cells.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614130987299,"sku":"HYBHM1132100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_ad1cc83f-5b59-4ec0-8272-8e302e7c1127.png?v=1753031023"},{"product_id":"lactoferrin-mouse-mab-1a10-20-ug","title":"Lactoferrin, Mouse, mAb 1A10, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614131020067,"sku":"HYBHM113220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1a1ac6c4-207b-4d34-8f2a-e5acb332dede.png?v=1753031026"},{"product_id":"lactoferrin-mouse-mab-1e4","title":"Lactoferrin, Mouse, mAb 1E4","description":"\u003cul\u003e\u003cli\u003eMonoclonal antibody clone 1E4 recognizes mouse lactoferrin (LF). The expression of small proteins and peptides with microbial activity, also called antimicrobial peptides (AMPs), is considered to be a primitive mechanism of immunity. AMPs are produced by almost all cell types which are commonly\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614131052835,"sku":"HYBHM1133100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1b21312d-d411-4b1f-959d-d4ee6cf56359.png?v=1753031030"},{"product_id":"lactoferrin-mouse-mab-1e4-20-ug","title":"Lactoferrin, Mouse, mAb 1E4, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614131085603,"sku":"HYBHM113320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_6c67914d-ba2c-4016-8e46-913230431492.png?v=1753031033"}],"url":"https:\/\/chromspec.com\/collections\/15498-antibody-name-l.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}