{"title":"15503-Antibody Name M","description":"","products":[{"product_id":"mcp-1-mouse-mab-ece-2","title":"MCP-1, Mouse, mAb ECE.2","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody ECE.2 recognizes mouse monocyte chemoattractant protein 1 (MCP-1).\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614117781795,"sku":"HYBHM1019100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_02d39c2c-a42d-4e23-a7c9-2ca05963e184.png?v=1753030578"},{"product_id":"mcp-1-mouse-mab-ece-2-20-ug","title":"MCP-1, Mouse, mAb ECE.2, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614117814563,"sku":"HYBHM101920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_41bbf688-3262-4df7-9ce6-12bbf613a887.png?v=1753030581"},{"product_id":"mbl-a-mouse-mab-8g6","title":"MBL-A, Mouse, mAb 8G6","description":"\u003cul\u003e\u003cli\u003eMannose Binding Lectin (MBL), also called mannosebinding protein (MBP), is a calcium dependent oligomeric protein that belongs to the collectin family of proteins. It contains a collagen-like domain and a carbohydrate recognition domain enabling MBL to recognize carbohydrates (such as mannose and N-acetylglucosamine) on pathogens. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways, by using attached mannose binding lectin-associated serine proteases (MASP-2) in an antibody- and C1q-independent manner. MASP-2 permits cleavage of C4 and C2 to form a C3 convertase. Once it has bound, MBL exhibits complement-dependent antibacterial activities such as microbial opsonization and\/or microbial lysis via membrane attack complexes and therefore plays an important role in innate immunity.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119125283,"sku":"HYBHM1035100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1671a262-057c-4415-af2f-921f7cf4748e.png?v=1753030669"},{"product_id":"mbl-a-mouse-mab-8g6-20-ug","title":"MBL-A, Mouse, mAb 8G6, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119158051,"sku":"HYBHM103520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_69e9a9d3-4352-4b26-a4fc-41ad35a1a979.png?v=1753030672"},{"product_id":"mbl-a-mouse-mab-2b4","title":"MBL-A, Mouse, mAb 2B4","description":"\u003cul\u003e\n\u003cli\u003eMannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r\/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A. The monoclonal antibody 2B4 is a calcium-dependent antibody.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119190819,"sku":"HYBHM1036100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d402df91-c5af-4530-b925-b4c489569fac.png?v=1753030676"},{"product_id":"mbl-a-mouse-mab-2b4-20-ug","title":"MBL-A, Mouse, mAb 2B4, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119223587,"sku":"HYBHM103620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_27ad718b-6d4e-4c23-adc8-bd8fe19c1c4d.png?v=1753030679"},{"product_id":"mbl-c-mouse-mab-16a8","title":"MBL-C, Mouse, mAb 16A8","description":"\u003cul\u003e\n\u003cli\u003eMannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r\/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q-independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A. The monoclonal antibody 16A8 is a calcium-dependent antibody.\u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119256355,"sku":"HYBHM1037100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5d5ecb60-c3f2-44a3-9b0d-a73ec8faf111.png?v=1753030682"},{"product_id":"mbl-c-mouse-mab-16a8-20-ug","title":"MBL-C, Mouse, mAb 16A8, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119289123,"sku":"HYBHM103720UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e4b06172-1df0-4576-a8e5-05c640730a99.png?v=1753030685"},{"product_id":"mbl-c-mouse-mab-14d12","title":"MBL-C, Mouse, mAb 14D12","description":"\u003cul\u003e\u003cli\u003eMannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119321891,"sku":"HYBHM1038100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1e597617-a3d6-45c5-86b2-6a589510187d.png?v=1753030689"},{"product_id":"mbl-c-mouse-mab-14d12-20-ug","title":"MBL-C, Mouse, mAb 14D12, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119354659,"sku":"HYBHM103820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_96b05cc2-17bf-4326-960a-4b392ec78e12.png?v=1753030692"},{"product_id":"md-1-mouse-mab-md113","title":"MD-1, Mouse, mAb MD113","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody MD113 reacts with mouse MD-1. MD-1 (22-25 kD) is an extracellular protein associated with the extracellular domain of RP105. The latter is a type 1 transmembrane protein with leucine-rich repeats. RP105 is similar to Drosophila Toll. MD-1 associated with RP105 (similar to TLR4\/MD-2) appears to be an essential molecule that helps RP105 on B-cells to signal to LPS. The MD113 antibody is antagonistic in LPS-induced B-cell proliferation and B7.2 up-regulation.\u003c\/li\u003e\n\u003cli\u003eApplications: Flow Cytometry , Functional Studies\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119747875,"sku":"HYBHM1040100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c7d81502-dd4f-4ef8-87dc-4684f031fe42.png?v=1753030621"},{"product_id":"md-1-mouse-mab-md113-20-ug","title":"MD-1, Mouse, mAb MD113, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614119780643,"sku":"HYBHM104020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_7415967a-1b66-4a54-8f09-598695fe96d0.png?v=1753030624"},{"product_id":"mpo-mouse-mab-8f4","title":"MPO, Mouse, mAb 8F4","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 8F4 recognizes mouse myeloperoxidase (MPO). MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa.- MPO is- stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614122336547,"sku":"HYBHM1051100UG","price":990.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_53bb435b-6e89-48b9-a2e0-e7cd5c0cd059.png?v=1753030687"},{"product_id":"mpo-mouse-mab-8f4-20-ug","title":"MPO, Mouse, mAb 8F4, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614122369315,"sku":"HYBHM105120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_42139c35-4470-40dd-b116-34f354716084.png?v=1753030690"},{"product_id":"mpo-mouse-mab-8f4-biotin-50-ug","title":"MPO, Mouse, mAb 8F4, Biotin, 50 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614122402083,"sku":"HYBHM1051BT50UG","price":630.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_51116a61-d5f2-40af-8a4f-89c9751703e1.png?v=1753030693"},{"product_id":"mpo-mouse-mab-8f4-fitc","title":"MPO, Mouse, mAb 8F4, FITC","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody 8F4 recognizes mouse myeloperoxidase (MPO). MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa.- MPO is- stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614122434851,"sku":"HYBHM1051F100UG","price":1108.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f25081da-4d42-4e14-8b68-355a0bfbda91.png?v=1753030697"},{"product_id":"mpo-mouse-mab-8f4-fitc-20-ug","title":"MPO, Mouse, mAb 8F4, FITC, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614122467619,"sku":"HYBHM1051F20UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_514d8716-6458-499e-8c0f-125fa41a328e.png?v=1753030700"},{"product_id":"macrophages-f4-80-mouse-mab-bm8","title":"Macrophages F4\/80, Mouse, mAb BM8","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody BM8 recognises a 125 kD extracellular macrophage membrane molecule, highly restricted to mature macrophage subpopulations residing in tissue. This murine F4\/80 glycoprotein contains seven-transmembrane (TM7) regions, which anchor the protein in the cell membrane, and thereby shows similarity in this region to G-protein-coupled receptors. The F4\/80 molecule shares overall structural homology to other members of the epidermal growth factor (EGF)-TM7 family. The antigen is detected on tissue fixed macrophages in all organs tested so far (spleen, lymph nodes, thymus, liver, skin). It is also present on Langerhans cells in the skin and Kupffer cells in the liver. It is absent on granulocytes, lymphocytes and trombocytes. The expression of F4\/80 increases upon maturation of macrophage precursors in bone marrow and blood as well as in ontogeny. The monoclonal antibody BM8 is the only macrophage marker that is able to distinguish non-destructive from destructive inflammation processes in the pancreas. Furthermore it is a unique histological marker of the progression from peri-insulitis to beta-cell destruction and diabetes in a mouse diabetes model. The monoclonal antibody BM8 cross reacts with human heart macrophages.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614124532003,"sku":"HYBHM1066100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_b8e57a2c-4028-448c-9466-1e0133e01d9b.png?v=1753030819"},{"product_id":"macrophages-f4-80-mouse-mab-bm8-20-ug","title":"Macrophages F4\/80, Mouse, mAb BM8, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614124564771,"sku":"HYBHM106620UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_97839b7e-44fb-4b6b-875f-229c047a3e5a.png?v=1753030822"},{"product_id":"mgl-mouse-mab-er-mp23","title":"MGL, Mouse, mAb ER-MP23","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody ER-MP23 specifically reacts with the macrophage galactose-specific lectin (MGL), a 38 kDa single chain surface glycoprotein. MGL is found on murine mature macrophages in the connective tissue neighboring epithelia of e.g. salivary glands, capsule of lymph nodes, thymus and various other organs. MGL is present on the surface of connective tissue macrophages and their precursor cells in bone marrow. Also, MGL is expressed in macrophage cell lines (e.g. J774-1.6, RAW309Cr.1 and WR19M.1). Expression levels of MGL are increased in mature macrophages. The antigen is co expressed with the antigen recognized by monoclonal antibody BM8 (HM1066). The monoclonal antibody ER-MP23 has been raised after immunization of rats with mouse macrophage cell lines. Blocking studies demonstrated that the monoclonal antibody ER-MP23 is able to block mouse MGL.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126170403,"sku":"HYBHM1081100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_96dc1d73-360d-4d9a-90ad-3cb55ecef063.png?v=1753030803"},{"product_id":"mgl-mouse-mab-er-mp23-20-ug","title":"MGL, Mouse, mAb ER-MP23, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126203171,"sku":"HYBHM108120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_5b9c4f20-b993-41d7-92e5-00b38c905c38.png?v=1753030807"},{"product_id":"mhc-class-ii-mouse-mab-er-tr3","title":"MHC class II, Mouse, mAb ER-TR3","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody ER-TR3 reacts with mouse major histocompatibitity complex class II (MHC class II), also known as I-A or I-E. MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen-presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they acquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC Class II. The monoclonal antibody ER-TR3 is a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells and macrophages) and for studying the development of T helper cells since they stain stromal cells in thymus. The level of antigen detected by ER-TR3 differs from strain to strain. The monoclonal antibody ER-TR3 cross reacts with human MHC class II on tonsil. Distribution of ER-TR3 among mouse strains with independent and recombinant haplotypes.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126498083,"sku":"HYBHM1087100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_100435f3-34e3-4230-a95b-6e8dee43aeae.png?v=1753030839"},{"product_id":"mhc-class-ii-mouse-mab-er-tr3-20-ug","title":"MHC class II, Mouse, mAb ER-TR3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126858531,"sku":"HYBHM108720UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_48013438-785c-45e9-afb9-187b93a41de4.png?v=1753030843"},{"product_id":"monocytes-macrophages-mouse-mab-er-hr3","title":"Monocytes\/Macrophages, Mouse, mAb ER-HR3","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody ER-HR3 is reactive to the majority of mouse monocytes and a subset of mature resident macrophages, especially those located in hemopoietic organs. Whereas all other leukocytes are ER-HR3 negative, up to 70% of circulating monocytes stain positive with this monoclonal antibody. Furthermore, about 30% of bone marrow cells express the antigen. Other ER-HR3 positive macrophages can be found in the splenic red pulp, in the mesenteric lymphoid paracortex, interfollicular areas of Peyer's patches and bone marrow. Few ER-HR3 positive cells are observed in the thymic cortex and the connective tissues of the gastro-intestinal tract, the dermis and the renal medulla. Epidermal Langerhans cells also express the antigen. The monoclonal antibody ER-HR3 can be used to identify and localize a very distinct mature tissue macrophage subpopulation found in various mouse organs and its distribution pattern is unique compared to that from other macrophage-specific antibodies. The antibody is especially suitable for ontogenic studies because ER-HR3 positive macrophages are closely related to hemopoietic islands, especially at erythropoietic sites.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Paraffin Sections\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126891299,"sku":"HYBHM1088100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_29d38c32-2d60-4bdb-810e-27bc7e4e16f7.png?v=1753030846"},{"product_id":"monocytes-macrophages-mouse-mab-er-hr3-20-ug","title":"Monocytes\/Macrophages, Mouse, mAb ER-HR3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126989603,"sku":"HYBHM108820UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_c7f6cbb5-8d67-460a-ac94-7aa7f038a1a8.png?v=1753030850"},{"product_id":"m-csf-mouse-mab-er-mp58","title":"M-CSF, Mouse, mAb ER-MP58","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody ER-MP58 recognizes an antigen present on all mouse macrophage colonystimulating factor (M-CSF) responsive cells in the bone marrow, including the earliest colony-forming myeloid progenitors, as well as by the majority of other myeloid precursors. The antigen is detected on a broad development range of macrophage precursor cells to the monocytic level, but also on granulocytes. Expression is rapidly lost upon maturation beyond the monocytic stage. The antigen disappears in the course of macrophage differentiation. Furthermore the antigen is clearly different from commonly used myeloid markers as Mac-1, F4\/80, and Gr-1.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614127022371,"sku":"HYBHM1089100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_8a925a8f-3003-4065-bf25-769d6e8b314d.png?v=1753030853"},{"product_id":"m-csf-responsive-cells-mouse-mab-er-mp58","title":"M-CSF-responsive cells, Mouse, mAb ER-MP58","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614127055139,"sku":"HYBHM108920UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_4a3d23cf-1e54-4823-9bcc-7ee749126aed.png?v=1753030856"},{"product_id":"mhc-class-i-mouse-mab-er-hr52","title":"MHC class I, Mouse, mAb ER-HR52","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody ER-HR52 specifically reacts with major histocompatibility complex (MHC) class I antigens of the mouse and, therefore, it is a valuable tool for studying cytotoxic T-cell interactions with class I positive antigen presenting cells. The primary immunological function of MHC molecules is to bind and present antigenic peptides on the surfaces of cells for recognition by the antigen-specific T cell receptors (TCRs) of lymphocytes. MHC class I molecules are expressed on the surfaces of most cells and are recognized by CD8-positive cytotoxic T-cells, an essential step for initiating the elimination of virally infected cells by T-cell-mediated lysis. MHC class I molecules are heterodimers composed of an alpha (44kD) and a beta (beta microglobulin, 11 kD) subunit. The first two structural domains of the alpha subunit associate to form the peptide-binding pocket. The monoclonal antibody ER-HR52 reacts with MHC class I, an antigen that is expressed by all somatic cells at varying levels. Lymphocytes are highly positive, whereas fibroblasts and neurons show only a low level of antigen expression. ER-HR52 recognizes murine MHC class I molecules on the surface of cells of the following haplotypes: H-2Db, H-2Dw16, H-2d,p,q. Weaker reactivity is found in mice of the following haplotypes: H-2f,r,s,w17, w23,w27. MHC class I molecules of other haplotypes are not recognized by ER-MP52. There is no cross-reactivity with human MHC class I molecules.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614127087907,"sku":"HYBHM1090100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1823f53f-8945-4f4b-8266-42c19b72fba1.png?v=1753030860"},{"product_id":"mhc-class-i-mouse-mab-er-hr52-20-ug","title":"MHC class I, Mouse, mAb ER-HR52, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614127120675,"sku":"HYBHM109020UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_a3de49b8-8d81-4b08-bf4e-5d65a3f86138.png?v=1753030863"},{"product_id":"mhc-class-i-mouse-mab-er-mp42","title":"MHC class I, Mouse, mAb ER-MP42","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody ER-MP42 specifically reacts with major histocompatibility complex (MHC) class I antigens of the mouse and, therefore, it is a valuable tool for studying cytotoxic T-cell interactions with class I positive antigen presenting cells. The primary immunological function of MHC molecules is to bind and present antigenic peptides on the surfaces of cells for recognition by the antigen-specific T cell receptors (TCRs) of lymphocytes. MHC class I molecules are expressed on the surfaces of most cells and are recognized by CD8-positive cytotoxic T-cells, an essential step for initiating the elimination of virally infected cells by T-cell-mediated lysis. MHC class I molecules are heterodimers composed of an alpha (44kD) and a beta (beta microglobulin, 11 kD) subunit. The first two structural domains of the alpha subunit associate to form the peptide-binding pocket. The monoclonal antibody ER-MP42 reacts with MHC class I, an antigen that is expressed by all somatic cells at varying levels. Lymphocytes are highly positive, whereas fibroblasts and neurons show only a low level of antigen expression. ER-MP42 recognizes murine MHC class I molecules on the surface of cells of the following haplotypes: H-2Fv, H-2Dd, H-2k,q,s. Weaker reactivity is found in mice of the following haplotypes: H-2p,r,w7,w22. MHC class I molecules of other haplotypes are not recognized by ER-MP42. There is no cross-reactivity with human MHC class I molecules.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614127153443,"sku":"HYBHM1091100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_99aaaf31-dcf0-45a9-b998-f7e5b56ba098.png?v=1753030867"},{"product_id":"mhc-class-i-mouse-mab-er-mp42-20-ug","title":"MHC class I, Mouse, mAb ER-MP42, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614127186211,"sku":"HYBHM109120UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_d4b93fd6-e84b-4214-a7c0-324e8121f8d7.png?v=1753030870"},{"product_id":"mpo-mouse-mab-b7","title":"MPO, Mouse, mAb B7","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody B7 recognizes human myeloperoxidase (MPO), an ~135 glycoprotein expressed in all cells of the myeloid linage. MPO functions as an α2β2 heteromultimer consisting of two heavy (α) and two light (β) chains of 55 and 15 kDa respectively. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils (PMNs). It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Upon activation of neutrophils, MPO can be rapidly released and as such useful in body fluids as marker for inflammatory status. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease, inflammatory bowel disease and multiple sclerosis. Autoimmune antibodies to MPO (so called ANCA) are involved in Wegener’s disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention. \u003c\/li\u003e\n\u003cli\u003eApplications: Immunoassays\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614131183907,"sku":"HYBHM1135100UG","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0c243523-b383-4b23-89fd-a64490511025.png?v=1753031006"},{"product_id":"mpo-mouse-mab-b7-20-ug","title":"MPO, Mouse, mAb B7, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614131216675,"sku":"HYBHM113520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_004d0992-3ae9-4a64-aa59-5985be77b6f1.png?v=1753031009"},{"product_id":"muc5ac-mucin-5ac-gastric-mucin-antibody-100-µg","title":"***MUC5AC (Mucin 5AC \/ Gastric Mucin) Antibody, 100 µg","description":"\u003cp class=\"richp\"\u003eMouse monoclonal antibody to MUC5AC\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eTarget: MUC5AC\u003c\/li\u003e\n\u003cli\u003eClonality: Monoclonal\u003c\/li\u003e\n\u003cli\u003eSpecies\/Host: Mouse\u003c\/li\u003e\n\u003cli\u003eIsotype: IgG1\u003c\/li\u003e\n\u003cli\u003eConjugation: Unconjugated\u003c\/li\u003e\n\u003cli\u003eReactivity: Feline, Gallus, Human, Mammal, Monkey, Mouse, Porcine, Rabbit, Rat\u003c\/li\u003e\n\u003cli\u003eForm\/Appearance: 200ug\/ml of Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% rAlbumin \u0026amp; 0.05% azide. Also available WITHOUT rAlbumin \u0026amp; azide at 1.0mg\/ml.\u003c\/li\u003e\n\u003cli\u003eImmunogen: M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient\u003c\/li\u003e\n\u003cli\u003eUniProt ID: P98088\u003c\/li\u003e\n\u003cli\u003eMW: \u0026gt;1000kDa\u003c\/li\u003e\n\u003cli\u003eTested applications: FC, IF, IHC\u003c\/li\u003e\n\u003cli\u003eDilution range: FACS: 0.5-1 μg\/million cells, IF\/ICC: 1-2 μg\/ml, IHC-P: 1-2 μg\/ml\u003c\/li\u003e\n\u003cli\u003eApplication notes: MUC5AC (Mucin 5AC \/ Gastric Mucin)\u003c\/li\u003e\n\u003cli\u003eClone Number: SPM297\u003c\/li\u003e\n\u003cli\u003eExpression System: HEK293 cells\u003c\/li\u003e\n\u003cli\u003eStorage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.\u003c\/li\u003e\n\u003cli\u003eResearch Area: Cardiovascular Research, Immunology \u0026amp; Inflammation, Infectious Disease \u0026amp; Virology Read less\u003c\/li\u003e\n\u003cli\u003eNote: For research use only\u003c\/li\u003e\n\u003cli\u003eExpiration Date: 12 months from date of receipt.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Biorbyt","offers":[{"title":"Default Title","offer_id":54391009804579,"sku":"ORB388468100UG","price":1072.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/biorbyt_antibody_2048x2048pxl_a7bbe7fc-a741-4ad9-a283-83d277bcc2e1.jpg?v=1774302211"},{"product_id":"muc5ac-mucin-5ac-gastric-mucin-antibody-20-µg","title":"***MUC5AC (Mucin 5AC \/ Gastric Mucin) Antibody, 20 µg","description":"\u003cp class=\"richp\"\u003eMouse monoclonal antibody to MUC5AC\u003c\/p\u003e\u003cul\u003e\n\u003cli sugg=\"true\"\u003eTarget: MUC5AC\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eClonality: Monoclonal\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eSpecies\/Host: Mouse\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eIsotype: IgG1\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eConjugation: Unconjugated\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eReactivity: Feline, Gallus, Human, Mammal, Monkey, Mouse, Porcine, Rabbit, Rat\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eForm\/Appearance: 200ug\/ml of Ab produced in HEK293 cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% rAlbumin \u0026amp; 0.05% azide. Also available WITHOUT rAlbumin \u0026amp; azide at 1.0mg\/ml.\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eImmunogen: M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eUniProt ID: P98088\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eMW: \u0026gt;1000kDa\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eTested applications: FC, IF, IHC\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eDilution range: FACS: 0.5-1 μg\/million cells, IF\/ICC: 1-2 μg\/ml, IHC-P: 1-2 μg\/ml\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eApplication notes: MUC5AC (Mucin 5AC \/ Gastric Mucin)\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eClone Number: SPM297\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eExpression System: HEK293 cells\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eStorage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eResearch Area: Cardiovascular Research, Immunology \u0026amp; Inflammation, Infectious Disease \u0026amp; Virology Read less\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eNote: For research use only\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eExpiration Date: 12 months from date of receipt.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Biorbyt","offers":[{"title":"Default Title","offer_id":54391010001187,"sku":"ORB38846820UG","price":552.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/biorbyt_antibody_2048x2048pxl_577e2146-8631-4690-8a05-d7a2a5cd1e16.jpg?v=1774302215"},{"product_id":"muc5ac-antibody-20-µg","title":"***MUC5AC Antibody, 20 µg","description":"\u003cp class=\"richp\" sugg=\"true\"\u003eThis mAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.It has been found that treating the testing sample with Papain or mercaptoethanol will destroy the M1 epitope for the 2-11M1 antibody (Ref. 1; Cancer Research 46.8 (1986): 3983-3989.)\u003c\/p\u003e\u003cp class=\"richp\" sugg=\"true\"\u003e\u003cb\u003eSpecifications:\u003c\/b\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli sugg=\"true\"\u003eAntibody Type: Primary Antibody\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eHost: Mouse \u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eClonality: Monoclonal \u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eIsotype: ;Mouse IgG1, kappa \u003c\/li\u003e\n\u003cli\u003eClone No.2-11M1 \u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eImmunogen: An M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient was used as the immunogen for the MUC5AC antibody. \u003c\/li\u003e\n\u003cli sugg=\"true\"\u003ePurification: Protein G affinity chromatography \u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eConjugation: Unconjugated\u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eStorage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. \u003c\/li\u003e\n\u003cli sugg=\"true\"\u003eDisclaimer: For research use only\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Biorbyt","offers":[{"title":"Default Title","offer_id":54671883436323,"sku":"ORB74969520UG","price":601.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/biorbyt_antibody_2048x2048pxl_f4112c62-f94d-4bff-977c-b5499853fa48.jpg?v=1774302253"}],"url":"https:\/\/chromspec.com\/collections\/15503-antibody-name-m.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}