{"title":"15521-Antibody Name P","description":"","products":[{"product_id":"pecam-1-mouse-mab-mec7-46","title":"PECAM-1, Mouse, mAb MEC7.46","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody MEC7.46 recognizes the mouse form of the platelet-endothelial cell adhesion molecule (PECAM)-1 (CD31). PECAM-1 is a member of the immunoglobulin superfamily. This heavily glycosylated protein is found in the entire vascular endothelium of adult mice and functions in mediating cellular adhesion by heterophilic and homophilic mechanisms. PECAM-1 is detected within the lymphopoietic islands in the spleen of newborn (day 12) and in the bone marrow of adult mice. Capillary endothelial cells of adult mice also express PECAM-1.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614117486883,"sku":"HYBHM1013100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_2ca10549-89cd-4dda-93c4-26c20dd61ab0.png?v=1753030552"},{"product_id":"pecam-1-mouse-mab-mec7-46-20-ug","title":"PECAM-1, Mouse, mAb MEC7.46, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614117519651,"sku":"HYBHM101320UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_22e77213-8f74-44da-9dd5-b7fb3d4b298f.png?v=1753030556"},{"product_id":"pecam-1-mouse-mab-er-mp12","title":"PECAM-1, Mouse, mAb ER-MP12","description":"\u003cul\u003e\u003cli\u003eThe monoclonal antibody ER-MP12 recognizes mouse platelet endothelial cell adhesion molecule-1 (PECAM-1;CD31). PECAM-1 is a 130kDa glycoprotein involved in- cell adhesion and a signalling receptor that is expressed on hematopoietic and endothelial cells. It is a member of the immunoglobulin (Ig)-superfamily of cell adhesion molecules. The type I transmembrane protein is composed of an extracellular region of six Ig-like homology domains, a 19-residue transmembrane domain, and a 118 residue cytoplasmic tail and is differentially glycosylated involving N-linked and O-linked glycosylation sites. The signalling of PECAM-1 is based on 2 immuno receptor tyrosine inhibitory motiFunctional Studies (ITIMs) in its cytoplasmic domain. These ITIM domains can serve as docking sites for signalling molecules such as protein tyrosine phosphatases, and ligation of PECAM-1 can induce phosphorylation of tyrosine- and serine\/threonine-residues of these intracellular regions eventually leading to activation of signalling pathways. The biological characteristics- of PECAM-1 in these pathways and cellular adhesion have been mapped to specific regions of the PECAM-1 molecule.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126367011,"sku":"HYBHM1084100UG","price":561.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f68293bf-6331-4e0c-bfeb-30878f77a4ea.png?v=1753030826"},{"product_id":"pecam-1-mouse-mab-er-mp12-20-ug","title":"PECAM-1, Mouse, mAb ER-MP12, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126399779,"sku":"HYBHM108420UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_e5601841-7697-4fe2-aa9e-a2dfc91b0f44.png?v=1753030829"},{"product_id":"pentraxin-3-mouse-mab-2c3","title":"Pentraxin 3, Mouse, mAb 2C3","description":"\u003cul\u003e\u003cli\u003eMonoclonal antibody 2C3 recognizes mouse pentraxin 3 (PTX3). The first line of defense against pathogens is represented by the innate immune system. An important part of this system is the recognition of pathogen associated molecular patterns (PAMPs) by pattern recognition molecules (PRMs). Pentraxins (PTXs) are a family of soluble cyclic pentameric PRMs. Based on primary structure, they can be divided in two groups, short and long PTXs. C-reactive protein (CRP) and serum amyloid P component (SAP) are prototypic short PTXs. Others have been classified as long PTXs. PTXs have a conserved ca 200 amino acid long c-terminal domain containing the PTX signature (HxCxS\/TWxS, where x is any amino acid). Human PTX3 encodes a 381 amino acid, 45 kDa secretory glycoprotein with a 162 amino acid N-terminal extension and a 202 amino acid C-terminal pentraxin domain. There is also a high degree of conservation between from mouse to man. PTX3 is the prototypic long PTX and was originally identified in endothelial cells and fibroblasts. Orthologs of PTX3 have been found in a variety of species. The PTX3 gene consists of three exons and two introns. The first two exons code for the leader peptide and the N-terminal domain of the protein, respectively, and the third exon encodes the pentraxin domain. PTX3 expression can among others be induced by proinflammatory cytokines like TNFα, Il1β and TLR agonists. Whereas short PTXs are produced in the liver, the main source of PTX3 expression are myeloid dendritic cells but expression is also seen in monocytes, macrophages, endothelial cells (constitutively expressed), fibroblasts, smooth muscle cells, kidney epithelial cells, synovial cells, chondrocytes, adipocytes, alveolar epithelial cells, granulosa cells and glial cells.\u003c\/li\u003e\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614130921763,"sku":"HYBHM1130100UG","price":645.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_55d26ece-7e62-4abf-bb30-4b15747df7b3.png?v=1753031016"},{"product_id":"pentraxin-3-mouse-mab-2c3-20-ug","title":"Pentraxin 3, Mouse, mAb 2C3, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default 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For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. \u003c\/li\u003e\n\u003cli\u003eForm\/Appearance:  Liquid \u003c\/li\u003e\n\u003cli\u003eBuffer\/Preservatives:  0.01M TBS (pH7.4) with 1% rAlbumin, 0.02% Proclin300 and 50% Glycerol. \u003c\/li\u003e\n\u003cli\u003eConcentration:  1mg\/ml \u003c\/li\u003e\n\u003cli\u003eExpiration Date:  12 months from date of receipt. \u003c\/li\u003e\n\u003cli\u003eDisclaimer:  For research use only\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Biorbyt","offers":[{"title":"Default Title","offer_id":55077569691939,"sku":"ORB1172783100UL","price":0.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/biorbyt_antibody_2048x2048pxl_fdb700e5-e904-4a2e-a855-5374a65b4947.jpg?v=1778603423"}],"url":"https:\/\/chromspec.com\/collections\/15521-antibody-name-p.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}