{"title":"15528-Antibody Name S","description":"","products":[{"product_id":"siglec-h-mouse-mab-440c","title":"Siglec-H, Mouse, mAb 440c","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody 440c reacts with Siglec-H, a cell-surface receptor molecule selectively expressed on murine natural interferon producing cells (IPC), also called mouse plasmacytoid dendritic cells (pDC). Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo. The monoclonal antibody 440c exclusively recognizes mouse Siglec-H in all lymphoid organs under both normal and inflammatory conditions. Siglec-H is normal present in the T cell zone of lymph nodes and spleen. Incubation of IPC with antibody 440c in vitro or administration of antibody 440c in vivo reduces secretion of IFN-alpha in response to CpG DNA without causing IPC depletion.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Flow Cytometry , Functional Studies\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614125580579,"sku":"HYBHM1075100UG","price":893.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_1d713219-458d-4daa-8fcb-eb8e0a540506.png?v=1753030749"},{"product_id":"siglec-h-mouse-mab-440c-20-ug","title":"Siglec-H, Mouse, mAb 440c, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614125613347,"sku":"HYBHM107520UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_0fd8ed02-8de0-440f-a631-b65db9afbec0.png?v=1753030752"},{"product_id":"sign-r1-mouse-mab-er-tr9-1-ml","title":"SIGN-R1, Mouse, mAb ER-TR9, 1 ml","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614126137635,"sku":"HYBHM10801ML","price":726.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_df17a9be-2639-49c8-84d0-660e7cc99b35.png?v=1753030799"},{"product_id":"s100a9-mouse-mab-mu14-2a5","title":"S100A9, Mouse, mAb MU14-2A5","description":"\u003cul\u003e\n\u003cli\u003eThe monoclonal antibody MU14-2A5 recognizes S100A9. The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. MRP14 is co-expressed with human MRP8, a homologue protein in myeloid cells, and plays an essential role in calcium dependent functions during inflammation. This role includes the activation of Mac-1, the β2 integrin which is involved in neutrophil adhesion to endothelial cells. MRP14 is distinguished from other S100 member proteins by its long C-terminal region. The expression of MRP-8 (S100A8) and MRP-14 (S100A9) is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8\/A9 heterocomplex, also called MRP-8\/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti-S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8\/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.\u003c\/li\u003e\n\u003cli\u003eApplications: Frozen sections, Functional Studies , Immunoassays , Immunofluorescence , Paraffin sections , Western Blot\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614128398627,"sku":"HYBHM1102100UG","price":799.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_44032a39-bdc1-4251-acf3-aef2d9176d3f.png?v=1753030923"},{"product_id":"s100a9-mouse-mab-mu14-2a5-20-ug","title":"S100A9, Mouse, mAb MU14-2A5, 20 µg","description":" ","brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614128431395,"sku":"HYBHM110220UG","price":265.9,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_dfc039ae-4ac0-4924-9f85-bc1d012ebfa5.png?v=1753030927"},{"product_id":"s100a9-mouse-mab-mu14-2a5-500-ug","title":"S100A9, Mouse, mAb MU14-2A5, 500 µg","description":null,"brand":"Hycult Biotech","offers":[{"title":"Default Title","offer_id":53614128496931,"sku":"HYBHM1102500UG","price":2080.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Hycult_20800x800_20100dpi_f0484d75-c386-4140-9f5c-9ea2c53c5a19.png?v=1753030930"}],"url":"https:\/\/chromspec.com\/collections\/15528-antibody-name-s.oembed","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}