**dCypher™ Nucleosome Full Panel, Ship Product on Dry Ice

SKU:
EP169001
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Description

Product Details

  • Understanding epigenetic reader proteins and their binding preference for post-translational modifications (PTMs) is key to unveiling how these proteins regulate genome processes and how their dysregulation may be contributing to disease. The dCypher™ Nucleosome Panel enables access to epigenetic diversity in a physiologically relevant context, the nucleosome, where chromatin reader activity can be accurately interrogated. The 96-well plate contains recombinant mononucleosomes as well as appropriate controls. Human histones expressed in E. coli bearing single and combinatorial histone post-translational modifications (PTMs) are wrapped by 147 or 199 base pair DNA with a 5’ biotin-TEG group and a central 601-positioning sequence.
  • All nucleosomes in the panel are subjected to EpiCypher’s rigorous quality control metrics, including: ESI-TOF mass spectrometry analysis of the modified histones, SDS-PAGE to confirm octamer composition and purity, native PAGE to confirm nucleosome assembly, and western blot analysis of the PTM, histone mutation, or histone variant (if applicable).
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EACH
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DRYICE - Product Ships with Dry Ice