Nectin-3, Mouse, mAb 103-A1

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HYBHM1053100UG
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Description

Product Details

  • The monoclonal antibody 103-A1 recognizes mouse nectin-3. Nectin-3 is a 83 kDa type I
  • transmembrane glycoprotein. Nectin, originally isolated as poliovirus receptor-related protein (PRR), is
  • a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectins are calciumindependent
  • immunoglobulin-like cell-cell adhesion molecules consisting of four members, nectin 1-4.
  • Nectins homophilically and heterophilically trans-interact to form a variety of cell-cell junctions,
  • including cadherin-based adherens junctions in epithelial cells and fibroblasts in culture, synaptic
  • junctions in neurons, and Sertoli cell-spermatid junctions in testis, in cooperation with, or
  • independently of, cadherins. Both nectin-2 and nectin-3 are ubiquitously expressed, whereas nectin-1
  • is abundantly expressed in brain. Nectin-2 and -3 are expressed in cells where cadherin is not
  • expressed, such as blood cells and spermatids. All members of the nectin family have two or three
  • splice variants. For nectin-3, three isoforms exist: nectin-3α, -3β and -3g of which nectin-3α is the
  • largest. Nectin-3, also known as PRR3, is a transmembrane protein that is predominantly expressed
  • in testis and placental tissues as well in many cell lines. Nectin interacts in vivo with both long and
  • short isoforms of afadin, an actin binding protein, at cadherin-based cell-cell adherence junctions in
  • various tissues and cell lines. Furthermore, the ectodomains of nectin-3 and CD155 (Poliovirus
  • Receptor) have shown strong affinity to each other.
  • Injection of antibody 103-A1 into lumen of seminiferous tubules leads to disruption of the actin
  • filaments in Sertoli cells at the Sertoli-maturing spermatid ectoplasmic specialization and exfoliation of
  • maturing spermatids form the seminiferous epithelium.
  • Applications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunofluorescence , Immunoprecipitation
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100UG
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