Activated C1s, Human, mAb M241

SKU:
HYBHM2109100UG
Pending approval

Log in for pricing

(No reviews yet)
Gift wrapping:
Options available
Current Stock:
Adding to cart… The item has been added
Description

Product Details

  • Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.
  • Applications: Frozen sections, Flow Cytometry , Functional Studies , Immunoassays , Immunoprecipitation , Paraffin sections , Western Blot
Additional Information
Sales Unit:
100UG
Additional_Shipping:
ROOMTEMP - Ships at Room Temperature