CD73, Human, mAb 4G4

SKU:
HYBHM2215100UG
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  • The monoclonal antibody 4G4 recognizes both membrane bound and soluble human CD73, alsoknown as ecto-5’-nucleotidase. CD73 is a 70-kDa GPI-anchored cell surface molecule and belongs tothe 5’-nucleosidase family. CD73 is useful as marker for lymphocyte differentiation. It is abundantlyexpressed on the vascular endothelium and at a low level on certain subpopulations of humanlymphocytes. Like many glycosyl-phosphatidylinositol (GPI)-anchored molecules, it transmits potentactivation signals in T cells when ligated by antibodies. CD73 hydrolyzes extracellular nucleotides intomembrane permeable nucleosides. Ecto-5’-nucleotidase activity is an important mediator of the antiinflammatory effect by converting extracellular AMP into a potent anti-inflammatory substanceadenosine. CD73 has been shown to function as a co-stimulatory molecule in human T cells and tohave a role in regulating lymphocyte adhesion. Triggering of CD73 on the surface of lymphocytes, butnot on endothelial cells, results in the shedding of the CD73 and increased adhesion of lymphocytesto endothelium via LFA-1 clustering. Furthermore, CD73 has been implicated to mediate homing oFunctional Studieskin-infiltrating lymphocytes in vivo. In B-cell chronic lymphocytic leukemia the expression of CD73 is decreased. Besides this, CD73activity has been implicated as sensitive and useful indicator for mild zinc deficiency.The monoclonal antibody 4G4 causes a reduction in CD73 expression on lymphocytes, reducesenzyme activity, and inhibits the binding of lymphocytes to endothelial cells.
  • Applications: Frozen sections, Flow Cytometry , Functional Studies , Immunofluorescence , Immunoprecipitation , Western Blot
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Sales Unit:
100UG
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ROOMTEMP - Ships at Room Temperature