Caveolin-1, Rat, mAb 7C8

SKU:
HYBHM3014100UG
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Description

Product Details

  • The monoclonal antibody 7C8 recognizes rat caveolin-1, a membrane protein of ~22 kDa. Caveolaeare sphingomyelin/cholesterol-rich membrane domains first discovered as membrane invaginations onthe surface of endothelial and epithelial cells. Caveolae are present in most cells, but are especiallyabundant in adipocytes. In addition to caveolins only two major protein components of caveolae wereidentified, namely the semicarbazide sensitive amine oxidase (SSAO) and the scavenger receptorCD36. Caveolin cycles between the plasma membrane and intracellular compartments via theendocytotic pathway. Caveolin is involved in the rapid intracellular transport of newly synthesizedcholesterol from the ER directly to the caveolae. Caveolin plays an important role in multiple signalingpathways, molecular transport and cellular proliferation and differentiation. Caveolin binds toendothelial nitric oxide synthase leading to enzyme inhibition. Furthermore caveolin is a candidatetumor suppressor gene in many tumors. The specific functions of caveolin-1/caveolae are highly celland context dependent.The monoclonal antibody 7C8 recognizes caveolin-1α as well as caveolin-1β, which are present inmany tissues, like aorta, heart, muscle, lung, adipose white, brown and epidydimal fat.The monoclonal antibody 7C8 can be used to immuno-isolate caveolae.
  • Applications: Immunofluorescence , Immunoprecipitation , Western Blot
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Sales Unit:
100UG
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ROOMTEMP - Ships at Room Temperature