***AGB1, CAS # 2776190-62-4, 5 mg, Ship with an Ice Pack

Biorbyt

SKU:

ORB1785999

Pending approval

(No reviews yet)

Gift wrapping:

Options available

Current Stock:

Quantity:

Adding to cart… The item has been added

Datasheet

AGB1 is a fast, highly selective, and potent bump-and-hole (B&H)-PROTAC degrader for BromoTag. AGB1 exhibits degradation for Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9. AGB1 exhibits binary affinity to VHL (Kd=125 nM). AGB1 exhibits favorable pharmacokinetic profile in mice with the DC50, 6 h of ～13 nM.