{"product_id":"aldosterone-cas-52-39-1-1-mg","title":"***Aldosterone, CAS # 52-39-1, 1 mg","description":"\u003cp class=\"richp\" sugg=\"true\"\u003eAldosterone, the principal mineralocorticoid, is produced in the adrenal cortex's zona glomerulosa upon activation of the renin-angiotensin system or elevated potassium intake. This small molecule is a key research tool for investigating hypertension, renal physiology, and electrolyte balance in both cellular and animal models.\u003c\/p\u003e\u003cp class=\"richp\" sugg=\"true\"\u003eIn Vivo:  Aldosterone (1 mg\/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP), and left ventricular end-diastolic pressure (LVEDP) . Aldosterone (0.72 mg\/kg\/day; 14 days) causes a small increase (14 mmHg) in blood pressure in male mice.\u003c\/p\u003e\u003cp class=\"richp\" sugg=\"true\"\u003eIn Vitro:  Aldosterone (1-1000 nM; 24 hours) dose-dependently inhibits interleukin-1β-stimulated nitrite production in vascular smooth muscle cells .\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eResearch Area:  Metabolism Research, Pharmacology \u0026amp; Drug Discovery\u003c\/li\u003e\n\u003cli\u003eCAS Number:  52-39-1 \u003c\/li\u003e\n\u003cli\u003eMW:  360.44 \u003c\/li\u003e\n\u003cli\u003ePurity:  99.00% (May vary between batches) \u003c\/li\u003e\n\u003cli\u003eFormula:  C21H28O5 \u003c\/li\u003e\n\u003cli\u003eSMILES:  C(=O)[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@H]2C(CO)=O)[H] \u003c\/li\u003e\n\u003cli\u003eTarget:  Endogenous Metabolite, Others\u003c\/li\u003e\n\u003cli\u003eStorage:  -20°C\u003c\/li\u003e\n\u003cli\u003eExpiration Date:  12 months from date of receipt. \u003c\/li\u003e\n\u003cli\u003eDisclaimer:  For research use only\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Biorbyt","offers":[{"title":"Default Title","offer_id":55600302588195,"sku":"ORB17062681MG","price":0.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/3870\/8003\/files\/Biorbyt_small_molecules_and_tools_2048x2048_1484cf3f-8e4e-4ac8-a884-12244bfc8055.jpg?v=1789492000","url":"https:\/\/chromspec.com\/products\/aldosterone-cas-52-39-1-1-mg","provider":"Chromatographic Specialties Inc.","version":"1.0","type":"link"}