Proteomics Technical Tips

Purification of target-enriched DNA is central to CUT&RUN (and CUT&Tag) chromatin mapping workflows.  When considering a DNA cleanup strategy, multiple methods are available:  phenol-chloroform extraction, column-based separation, and SPRI bead technology.  With so many options, how can you besure you've selected the right method?

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The "histone code" hypothesis postits that epigenetic features, specifically histone post-transitional modifications (PTMs), act as a unique molecular language to regulate chromatin structure and gene expression1-3. But how does this work?...

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Many components of the biotechnology and medical toolbox have their origins in pathogenic microorganisms.  These have been adapted to generate useful tools and therapies for research and medicine.  Now Caf1 proteins, also known as Cytotoxic Assocation Factor 1...

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Affinity purification (also called affinity chromatography) is recognized as the most powerful method of purification chromatography or enriching a protein of interest from a complex mixture such as a crude cell lysate, cell culture supernatant, or other samples...

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Glycosylation plays a vital role in a multitude of biological processes. It is no surprise that it has become a key area of study to understand human diseases.  The importance of the glycome - the complete set of sugar composition of a cell or organism - was first evidenced by...

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