***Aldosterone, CAS # 52-39-1, 1 mg

Aldosterone, the principal mineralocorticoid, is produced in the adrenal cortex's zona glomerulosa upon activation of the renin-angiotensin system or elevated potassium intake. This small molecule is a key research tool for investigating hypertension, renal physiology, and electrolyte balance in both cellular and animal models.

In Vivo:  Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP), and left ventricular end-diastolic pressure (LVEDP) . Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase (14 mmHg) in blood pressure in male mice.

In Vitro:  Aldosterone (1-1000 nM; 24 hours) dose-dependently inhibits interleukin-1β-stimulated nitrite production in vascular smooth muscle cells .

• Research Area:  Metabolism Research, Pharmacology & Drug Discovery
• CAS Number:  52-39-1
• MW:  360.44
• Purity:  99.00% (May vary between batches)
• Formula:  C21H28O5
• SMILES:  C(=O)[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@H]2C(CO)=O)[H]
• Target:  Endogenous Metabolite, Others
• Storage:  -20°C
• Expiration Date:  12 months from date of receipt.
• Disclaimer:  For research use only