FGF-22, Species: Human

Fibroblast Growth Factor 22 (FGF-22) is a mediator of synaptogenesis in the adult nervous system and functions to regulate synapse formation and maturation. FGF-22 is expressed in the inner hair cell and functions to maintain ribbon synapse number to protect functional hearing. In the hippocampus, FGF-22 promotes excitatory synapse formation through binding the FGFR2b and FGFR1 β receptors. FGF-22 is also required for axonal circuit remodeling after spinal cord injury.