Garcinol

Garcinol is a polyisoprenylated benzophenone derivative from the rind of Garcinia indica fruit and is a potent inhibitor of histone acetyltransferases p300 and PCAF in-vitro. p300 also known as E1A binding protein p300 regulates cell growth and division through interacting with numerous transcription factors and the p53 associated trancriptional coactivator PCAF (P300/CBP-associated factor) plays a direct role in transcriptional regulation.