IL-17F, Species: Human

Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor ? 1 (TGF-?1).