IL-35, Species: Human

Interleukin-35 (IL-35) is a member of the IL-12 cytokine family and is produced by regulatory T cells (Tregs). IL-35 is a heterodimeric cytokine that is comprised of the interleukin-12 subunit P35 (IL-12 ?) and the interleukin-27 subunit ? (IL-27 ?) chains. IL-35 binds the IL-12R?2/gp130 hetero- and homodimers to activate STAT1 and STAT4 signaling. IL-35 functions as a suppressor of immune cell inflammatory responses.