NGF-β (AF), Species: Human

Nerve Growth Factor β (NGF-β) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF-β signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF-β is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat NGF-β proteins are cross-reactive.